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Method for clean production of lactic acid by calcium salt process

A technology of clean production and calcium salt method, applied in the direction of microorganism-based methods, biochemical equipment and methods, separation/purification of carboxylic acid compounds, etc., can solve high energy consumption, complex selectivity and system composition, and difficult to guarantee purity and other problems, to achieve the effect of overcoming calcium sulfate waste residue

Inactive Publication Date: 2011-10-19
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can avoid the calcium sulfate produced by the calcium salt method, but there are still defects in this method: on the one hand, the harvested product relies on the transmembrane migration of lactic acid, and lactic acid is a weak acid, and the migration of lactate in the ion exchange membrane is slower than that of inorganic acid. , leading to high energy consumption; on the other hand, due to the selectivity of the membrane and the complexity of the system composition, it is difficult to guarantee the purity of the target product directly using bipolar membrane electrodialysis
However, due to the performance problems of lactic acid fermentation strains, the concentration of lactic acid fermentation liquid obtained by adjusting the pH of the fermentation liquid with NaOH is lower than the concentration of the traditional lactic acid fermentation liquid obtained by adjusting the pH of the fermentation liquid with calcium carbonate.

Method used

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  • Method for clean production of lactic acid by calcium salt process
  • Method for clean production of lactic acid by calcium salt process
  • Method for clean production of lactic acid by calcium salt process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Step 1) prepare lactic acid fermentation liquid:

[0091] The microbial strain used was Lactobacillus paracasei (Lactobacillus paracasei, NERCB0401 (Industrial Microbiology, 2007, Vol. 37, Issue 4, 1-5)), and fed-batch fermentation was carried out with the above strain. There are two types of media used:

[0092] (1) Seed medium: glucose 40g / L, peptone 10g / L, beef extract 10g / L, yeast powder 5g / L, diammonium hydrogen citrate 2g / L, sodium acetate 5g / L, dipotassium hydrogen phosphate 2g / L L, Tween 801mL / L, magnesium sulfate 0.6g / L, manganese sulfate 0.25g / L.

[0093] (2) Fermentation medium: glucose 60g / L, peptone 10g / L, beef extract 6g / L, yeast powder 10g / L, sodium chloride 0.03g / L, ferrous sulfate 0.01g / L, sodium acetate 4g / L , diamine citrate 2g / L, potassium dihydrogen phosphate 2g / L, Tween-801mL / L, magnesium sulfate 0.2g / L, manganese sulfate 0.2g / L.

[0094] Two kinds of media were prepared according to the above formula and sterilized at 121°C for 15 minutes, in w...

Embodiment 2

[0104] Step 1) Preparation of lactic acid fermented liquid: same as step 1) of Example 1, to obtain about 3.4 liters of fermented liquid containing calcium lactate with a lactic acid concentration of 160 g / L.

[0105] Sterilization: Pass the fermented liquid obtained in step 1) through a 0.2 μm microfiltration membrane of Tianjin Motianmo Engineering Technology Co., Ltd. to obtain 3 liters of fermented clear liquid with a lactic acid concentration of about 160 g / L.

[0106] Step 2) Precipitation replacement: Add 5.1mol / L sodium carbonate solution in the above-mentioned sterilized fermented liquid, the volume ratio is about 5: 1, fully stir and mix, make it react completely; Filter to obtain calcium carbonate solid and lactic acid concentration 134g / L L of fermentation broth containing sodium lactate is about 3.5L.

[0107] Step 3) Ion-exchange column adsorption of lactic acid: 3.15 liters of fermented liquid containing sodium lactate obtained in step 2) is passed through an io...

Embodiment 3

[0113] Step 1) Preparation of lactic acid fermented liquid: same as step 1) of Example 1, obtain about 3.5 liters of fermented liquid containing calcium lactate with a lactic acid concentration of 160 g / L.

[0114] Sterilization: pass the fermented liquid obtained in step 1) through the 0.2 μm microfiltration membrane of Tianjin Motianmo Engineering Technology Co., Ltd. to obtain about 3.1 liters of fermented clear liquid with a lactic acid concentration of about 160 g / L.

[0115] Step 2) Precipitation replacement: Add 5.0mol / L potassium carbonate solution in the above-mentioned sterilized fermentation broth, the volume ratio is about 5.1: 1, fully stir and mix, make it react completely; filter to obtain calcium carbonate solid and lactic acid concentration 134g / L L of fermentation broth containing potassium lactate is about 3.5L.

[0116] Step 3) Ion-exchange column adsorption of lactic acid: pass 3.45 liters of fermented liquid containing potassium lactate obtained in step 2...

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Abstract

The invention relates to a method for clean production of lactic acid by a calcium salt process, which comprises: regulating the pH value of fermentation liquid by using CaCO3; adding carbonate to perform a precipitation displacement reaction to obtain solution of soluble lactate and a CaCO3 precipitate; loading the solution of soluble lactate on an anion exchange column, so that lactates are absorbed onto the column and ion exchange permeate passing through the anion exchange column is obtained; eluting the anion exchange column with acid to obtain extrication liquid containing lactic acid; and subjecting the ion exchange permeate to bipolar membrane electrodialysis to obtain regenerated acid, alkali and desalted waste solution. The method for clean production of lactic acid by the calcium salt process completely overcome the drawback of production of calcium sulfate waste slag in production of lactic acid by the conventional production technique and can be connected with the conventional lactic acid fermentation step directly.

Description

technical field [0001] The invention relates to a method for cleanly producing lactic acid by a calcium salt method. Background technique [0002] Lactic acid and its salts and esters are widely used. At present, lactic acid is mostly prepared by fermentation, and the fermentation broth is extracted by calcium salt method. The main process steps of calcium salt extraction can be briefly described as: adjusting the pH value of the fermentation broth - heat treatment - filtration - activated carbon decolorization - filtration - sulfuric acid hydrolysis - decolorization - filtration - purification - concentration - finished product. Among them, calcium carbonate (limestone) or calcium oxide (milk of lime) is generally used to adjust the pH of the initial fermentation liquid, so that calcium sulfate precipitation will be accompanied by the step of sulfuric acid acid hydrolysis to generate crude lactic acid. [0003] However, for the large amount of CaSO produced in the sulfuri...

Claims

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Application Information

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IPC IPC(8): C12P7/56C07C59/08C07C51/42C12R1/225C12R1/845
Inventor 丛威杨鹏波王丽静张勇王倩吴霞
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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