Amphotericin B cream and preparation method thereof
A technology for amphotericin and cream, which is applied in the field of amphotericin B cream and its preparation, can solve problems such as unstable quality, limited popularization and application, and increased cost, and achieve reduction of toxic and side effects, simple preparation process, and compliance Good results
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Embodiment 1
[0033] formula:
[0034] Amphotericin B 30g, glyceryl monostearate 35g, stearic acid 50g, cetostearyl alcohol 40g, sodium lauryl sulfate 8g, ethylparaben 1g, propylene glycol 100g, azone 10g, 25g of methyl silicone oil, an appropriate amount of purified water to a total weight of 1000g.
[0035] Preparation:
[0036] ①Take the prescribed amount of glyceryl monostearate, stearic acid, and cetostearyl alcohol, heat and melt in a water bath, the temperature of the water bath is 80°C, add simethicone and azone after melting, stir well, and make oil phase;
[0037] ② Take sodium lauryl sulfate, ethylparaben, and propylene glycol, add appropriate amount of purified water, place in 80°C water bath, stir to fully dissolve, then add amphotericin B raw material, stir to make it fully dispersed in the water phase middle;
[0038] ③Under stirring, mix the water phase and the oil phase, add purified water to the full amount, stir and emulsify, leave it at room temperature, detect the c...
Embodiment 2
[0040] prescription:
[0041] Amphotericin B 30g, Glyceryl Monostearate 30g, Stearic Acid 30g, Cetearyl Alcohol 45g, Sodium Lauryl Sulfate 8g, Propylparaben 2g, Glycerol 100g, Azone 10g , 400ml of 0.16% sodium hydroxide solution, and an appropriate amount of purified water to a total weight of 1000g.
[0042] Preparation:
[0043] ①Take the prescribed amount of glyceryl monostearate, stearic acid, and cetostearyl alcohol, heat and melt in a water bath, the temperature of the water bath is 70°C, add azone after melting, stir evenly, and make an oil phase;
[0044] ②Add sodium lauryl sulfate, propylparaben, and glycerin to an appropriate amount of purified water, place in a water bath at 70°C, stir to fully dissolve, and obtain an aqueous phase;
[0045] ③Take the amphotericin B bulk drug, add 400ml of 0.16% sodium hydroxide solution, place it in a 40°C water bath and stir to dissolve it;
[0046] ④In the state of stirring, add the water phase to the oil phase, stir and mix, ...
Embodiment 3
[0048] prescription:
[0049] Amphotericin B 30g, Glyceryl Monostearate 50g, Cetostearyl Alcohol 70g, Sodium Lauryl Sulfate 10g, Benzyl Alcohol 2g, Propylene Glycol 100g, Azone 10g, Dimethyl Sulfoxide 100g, 0.16% 300ml of sodium hydroxide solution, and an appropriate amount of purified water until the total weight is 1000g.
[0050] Preparation:
[0051] ① Take the prescribed amount of glyceryl monostearate and cetostearyl alcohol, heat and melt in a water bath, the temperature of the water bath is 80°C, add azone after melting, stir evenly, and make an oil phase;
[0052] ② Add sodium lauryl sulfate, benzyl alcohol, and propylene glycol to an appropriate amount of purified water, place in a water bath at 70°C, stir to fully dissolve, and obtain an aqueous phase;
[0053] ③Take the amphotericin B bulk drug, add dimethyl sulfoxide and 0.16% sodium hydroxide solution, place it in a 45°C water bath and stir to dissolve it;
[0054] ④In the state of stirring, add the water phas...
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