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Evening primrose oil microcapsule and pulverization method

A technology of microcapsules and powdering, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of high energy consumption of evening primrose oil microcapsules, high requirements on wall material specifications, poor capsule shell compactness, etc. Antioxidant performance, good dispersibility, good film-forming effect

Inactive Publication Date: 2011-10-05
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of evening primrose oil microcapsules by this method requires high energy consumption, high wall material specifications, complicated operation, difficult control, high production cost, poor compactness of the formed capsule shell, poor oxidation resistance, and short shelf life of the product.

Method used

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  • Evening primrose oil microcapsule and pulverization method
  • Evening primrose oil microcapsule and pulverization method
  • Evening primrose oil microcapsule and pulverization method

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A method for powdering evening primrose oil microcapsules. The method uses a solvent-non-solvent method to coat evening primrose oil into microcapsules. The solvent-non-solvent method includes the following steps:

[0028] 1) Mix acrylic resin No. II or acrylic resin No. III or a mixture of acrylic resin No. II and acrylic resin No. III in a certain proportion, dissolve in ethanol, and use it as a wall material solution.

[0029] ) by adding evening primrose oil and polyoxyethylene hydrogenated castor oil RH40, high-shear emulsification and dispersion to form a stable O / W emulsion.

[0030] ) Stirring and adding sodium lauryl sulfate solution to the core material, wall material and medium at the same time, with the continuous increase of water content in the system, the concentration of ethanol is reduced, resulting in a decrease in the solubility of the wall material, and the core material is precipitated from the system Evening primrose oil is coated to form microcaps...

Embodiment 2

[0033] An evening primrose oil microcapsule, which consists of: evening primrose oil core material, acrylic resin II or acrylic resin III or acrylic resin II and acrylic resin III, polyoxyethylene hydrogenated castor oil RH40, characterized in that: The parts by weight of the evening primrose oil core material is 1, and the parts by weight of the acrylic resin II or acrylic resin III or acrylic resin II and acrylic resin III are 0.6 to 8.5 parts by weight; the polyoxyethylene hydrogenated castor oil The parts by weight of RH40 are 0.05-0.5. attached image 3 Middle (?) is evening primrose oil; (▲) is evening primrose oil microcapsules.

Embodiment 3

[0035] For the evening primrose oil microcapsules and powdering method described in the above examples, weigh 8 g of acrylic resin No. II and No. III (1:1) and dissolve them in 95% ethanol, then add 2 g of evening primrose oil, Polyoxyethylene hydrogenated castor oil RH40 0.2 g, 10000 rpm homogeneous emulsification for 2 min, 0.2% sodium lauryl sulfate solution was added dropwise with a 50 ml acidic burette, while stirring continuously at 1000 rpm until a large number of microcapsule solids were precipitated in the solution , filtered and then washed twice with 0.2% sodium lauryl sulfate solution, filtered and dried under reduced pressure to obtain evening primrose oil microcapsule powder. The final evening primrose oil microcapsules were white powder with good fluidity and good anti-oxidation ability. The average particle size of the microcapsules was determined by laser particle size analyzer to be 7.66 μm, and the encapsulation efficiency was 95.7%.

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Abstract

The invention relates to an evening primrose oil microcapsule and a pulverization method. Evening primrose oil is difficult to dissolve in water and ethanol, is easy to be oxidized by oxygen and has a special grease taste; currently, crude evening primrose oil and evening primrose oil soft microcapsule are mainly products in a market, thereby greatly limiting the application range of the evening primrose oil as a functional health care product and a food additive. The evening primrose oil microcapsule is characterized by comprising the following components in parts by weight: 1 part of evening primrose oil core material, 0.6-8.5 parts of acrylic resin II or acrylic resin III or acrylic resin II and acrylic resin III and 0.05-0.5 part of polyoxyethylene hydrogenated castor oil RH40. The evening primrose oil microcapsule is applied to the field of medicaments.

Description

Technical field: [0001] The invention relates to a method for use in the field of medicine; in particular, it relates to a microcapsule of evening primrose oil and a powdering method. Background technique: [0002] Evening primrose is a wild plant in Northeast my country, with abundant reserves and wide sources. Its seed oil is called evening primrose oil, which has various physiological activities. Evening primrose oil contains a variety of unsaturated fatty acids that are necessary for human growth and cannot be synthesized in the body, such as linolenic acid, linoleic acid, arachidonic acid, and γ-linolenic acid, which is rare in the plant kingdom. The human body can also convert various fatty acids to meet the physiological needs of the human body, but for a few specific fatty acids such as γ-linolenic acid, linoleic acid and linolenic acid, the human body cannot synthesize them by itself and must be obtained through food intake . Modern pharmacological studies have pr...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/50A61K47/32A61K47/34A61P3/04A61P3/06A61P7/02A61P9/10A61P29/00A61P39/06
Inventor 李强张士伟赵学玲龚显峰刘丽娟
Owner HEILONGJIANG UNIV
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