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Method for preparing hypophosphorous acid (salt) and gluconic acid (salt) from glucose phosphate serving as raw material

A technology of gluconate and gluconic acid, which is applied in the direction of carboxylate preparation, hypophosphorous acid, phosphorus oxyacid, etc., can solve the problems of long production cycle, complex process, low yield, etc., achieve low cost, easy filtration and separation, Easy to save effects

Inactive Publication Date: 2011-09-21
石允生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The gluconic acid produced by this method has a long production cycle, complicated process and low yield.

Method used

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  • Method for preparing hypophosphorous acid (salt) and gluconic acid (salt) from glucose phosphate serving as raw material
  • Method for preparing hypophosphorous acid (salt) and gluconic acid (salt) from glucose phosphate serving as raw material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment (1

[0042] ① Add disodium hydrogen phosphate (Na 2 HPO 4 .12H 2 O) 716g, glucose (C 6 h 12 o 6 ) 180g, put in a high temperature resistant glass container. ②Place the prepared mixed solution in a high-pressure steam boiler to increase the pressure to 125°C (0.135MPa) for 30 minutes. ③Add 252g of calcium oxide ( CaO), and filtered while hot (80°C to 100°C) to remove the precipitate. ④Heat and concentrate at 100°C to obtain calcium gluconate precipitate. ⑤ Add the precipitate to 1L of pure water, heat (80°C to 100°C) to dissolve the precipitate. While it is hot (70°C~100°C), feed CO 2 Gas, filter to remove the precipitate, you can get high-purity gluconic acid. ⑥ Add various alkaline oxides (56g calcium oxide or 81g zinc oxide, etc.) and hydroxides (40g sodium hydroxide or 56g potassium hydroxide, etc.) to the obtained gluconic acid solution to obtain high-purity glucose salt.

Embodiment (2

[0044] ① Add disodium hydrogen phosphate (KH 2 PO 4 ) 136 grams, glucose (C 6 h 12 o 6 ) 180 grams, add caustic soda 40g (NaOH), make the pH of solution>8. ②Place the prepared mixed solution in a high-pressure steam boiler to increase the pressure to 125°C (0.135MPa) for 30 minutes. ③Add 252g of calcium oxide to the heated mixed solution while it is hot (80°C-100°C), Remove the precipitate by filtration while hot (80°C-100°C). ④Heat and concentrate at 100°C to obtain calcium gluconate precipitate. ⑤ Add the precipitate to 1L of pure water, heat (80°C to 100°C) to dissolve the precipitate. While it is hot (70°C~100°C), feed CO 2 Gas, filter to remove the precipitate, you can get high-purity gluconic acid. ⑥ Add various alkaline oxides (56g calcium oxide or 81g zinc oxide, etc.) and hydroxides (40g sodium hydroxide or 56g potassium hydroxide, etc.) to the obtained gluconic acid solution to obtain high-purity glucose salt.

[0045] (2) Preparation of hypophosphorous aci...

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Abstract

The invention discloses a method for preparing hypophosphorous acid (salt) and gluconic acid (salt) from glucose phosphate serving as a raw material, which comprises the following steps of: (1) preparing raw materials: preparing subphosphate or acid phosphate and glucose, and taking water as a solvent; (2) heating: continuously heating mixed solution at the temperature of more than or equal to 100DEG C under the air pressure of more than or equal to 0.01MPa for more than 10 minutes; (3) separating: adding a separating agent, concentrating, and separating to obtain crude products of gluconic acid salt and hypophosphorous acid salt; (4) purifying: filtering to remove precipitates to obtain gluconic acid, adding a gas or a solvent capable of reacting with the hypophosphorous acid salt into aqueous solution of the separated hypophosphorous acid salt, and filtering to remove precipitates to obtain hypophosphorous acid; (5) preparing the hypophosphorous acid salt: reacting the hypophosphorous acid with basic oxide or hydroxide to obtain the hypophosphorous acid salt; and (6) preparing the gluconic acid salt: reacting the gluconic acid with basic oxide or hydroxide to obtain the gluconicacid salt. The production process is environment-friendly and harmless, raw materials are readily available, the cost is low, the yield is high, the period is short and the safety is achieved.

Description

technical field [0001] The invention relates to the field of pharmaceutical and chemical manufacturing, in particular to a method for preparing hypophosphorous acid (salt) and gluconic acid (salt) by using glucose phosphate as a raw material. Background technique [0002] The preparation of hypophosphorous acid in the past is to dissolve white phosphorus in barium hydroxide solution, and then use sulfuric acid to remove barium ions to obtain hypophosphorous acid and generate phosphine waste gas at the same time. Or by the reaction of phosphine and iodine. Yellow phosphorus is flammable, barium is a rare metal, sulfuric acid is highly corrosive, phosphine is explosive, and iodine is also highly corrosive. There are serious hidden dangers of production safety, threatening the personal safety of workers. [0003] The preparation of gluconic acid is made from glucose through air oxidation or biological fermentation. The gluconic acid produced by this method has a long product...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/105C07C51/41C01B25/165
Inventor 石允生石仁卿
Owner 石允生
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