Nanometer pore hydroxyl calcium phosphate/aquogel materials
A calcium hydroxyphosphate and hydrogel technology, applied in the field of biomedicine, can solve problems such as ignoring the role of water-soluble proteins
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Embodiment 1
[0074] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:
[0075] (1) Prepare a hydrophilic polymer aqueous solution with a mass concentration of 1%, prepare a glutaraldehyde aqueous solution with a mass concentration of 3%, and prepare a polypeptide aqueous solution with a concentration of 10 μg / ml,
[0076] The above-mentioned hydrophilic polymer is collagen; the above-mentioned polypeptide is osteopontin (osteopontin, OPN) contained in bones; the hydrophilic polymer material is added with a mass percentage of 0.0001% of a small molecular compound that promotes the proliferation of osteoblasts .
[0077] (2) Preparation of hydrogel substrate: Mix the three aqueous solutions prepared in step (1) according to the volume ratio of 1:1:1, stir at room temperature for 0.5 minutes, and then place the mixture on the carrier, The hydrogel substrate was prepared by phase separation technique, a...
Embodiment 2
[0082] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:
[0083] (1) Prepare a hydrophilic polymer aqueous solution with a mass concentration of 5%, prepare a glutaraldehyde aqueous solution with a mass concentration of 8%, and prepare a polypeptide aqueous solution with a concentration of 300 μg / ml,
[0084] The above-mentioned hydrophilic polymer is gelatin; the above-mentioned polypeptide is phosphophoryn or its fragments contained in teeth; the above-mentioned hydrophilic polymer material is added with a mass percentage of 5% of a small molecular compound that promotes the proliferation of osteoblasts.
[0085] (2) Preparation of hydrogel substrate: Mix the three aqueous solutions prepared in step (1) according to the volume ratio of 1:1:1, stir at room temperature for 10 minutes, and then place the mixture on the carrier, The hydrogel substrate was prepared by phase separation tech...
Embodiment 3
[0090] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:
[0091] (1) Prepare a hydrophilic polymer aqueous solution with a mass concentration of 3%, prepare a glutaraldehyde aqueous solution with a mass concentration of 6%, and prepare a polypeptide aqueous solution with a concentration of 150 μg / ml,
[0092] The above-mentioned hydrophilic macromolecule is a composition of collagen and gelatin, and the weight ratio of collagen and gelatin is 1:3; the above-mentioned polypeptide is a polypeptide rich in aspartic acid, wherein the sum of said aspartic acid accounts for The weight percentage is 10%; the hydrophilic polymer material is added with a mass percentage of 2.5% of a small molecular compound that promotes the proliferation of osteoblasts.
[0093] (2) Preparation of hydrogel substrate: Mix the three aqueous solutions prepared in step (1) according to the volume ratio of 1:1:1, st...
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