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Preparation method of Chinese medicinal tablet for treating skin diseases

A technology of traditional Chinese medicine tablets and skin diseases, applied in the field of medicine, can solve the problems of low dissolution rate and low bioavailability of traditional Chinese medicine pills

Active Publication Date: 2011-09-14
史志辉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the deficiency that the dissolution rate and bioavailability of traditional Chinese medicine pills are not high, proposes a kind of preparation method of Chinese medicine tablet, optimizes the crushing process, granulation process, tabletting process, coating process of this Chinese medicine tablet, makes The pulverization yield of the Chinese medicine tablet is 98.9%, the disintegration time limit is controlled at 22min, and the qualified rate of coating reaches 98.8%. 89.7%, meeting the requirements of industrial production

Method used

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  • Preparation method of Chinese medicinal tablet for treating skin diseases
  • Preparation method of Chinese medicinal tablet for treating skin diseases
  • Preparation method of Chinese medicinal tablet for treating skin diseases

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Effect test

Embodiment 1

[0019] Embodiment 1 Chinese medicine tablet preparation process optimization

[0020] The thirty-nine Chinese herbal medicines in the present invention are all purchased from the Chengyang Medicinal Material Company in Shaanxi Province, and the auxiliary materials are all purchased from the Chemical Glass Procurement and Supply Station in Shanxi Province, and all of them meet the statutory standards after identification. Before preparing traditional Chinese medicine tablets, the medicinal materials are pre-treated, and the various medicinal materials in the prescription are cleaned and processed for preparation.

[0021] 1. Optimization of crushing process: Weigh madder, peach kernel, nepeta ear charcoal, red peony root, angelica, Kochia chinensis, fried cocklebur, rehmannia glutinosa, forsythia, honeysuckle, Kudiding, Smilax cocos, saponins, Platycodon grandiflorum, motherwort, peeled and fried bitter almonds, white peony root, fried burdock seeds, peony bark, white fresh bar...

Embodiment 2

[0073] Embodiment 2 prepares Chinese medicine tablet

[0074] The thirty-nine Chinese herbal medicines in the present invention are all purchased from the Chengyang Medicinal Material Company in Shaanxi Province, and the auxiliary materials are all purchased from the Chemical Glass Procurement and Supply Station in Shanxi Province, and all of them meet the statutory standards after identification. Before preparing traditional Chinese medicine tablets, the medicinal materials are pre-treated, and the various medicinal materials in the prescription are cleaned and processed for preparation.

[0075] Accurately weigh madder, peach kernel, nepeta ear charcoal, red peony root, angelica, Kochia scoparia, fried cocklebur, rehmannia glutinosa, forsythia, honeysuckle, Kudiding, soil Poria, saponins, platycodon grandiflorum, motherwort, peeled Stir-fried bitter almonds, white peony root, fried burdock seeds, peony bark, white fresh bark, rehmannia glutinosa, wine-fried rhubarb, honeysuc...

Embodiment 3

[0077] Embodiment 3 prepares Chinese medicine tablet

[0078] The thirty-nine Chinese herbal medicines in the present invention are all purchased from the Chengyang Medicinal Material Company in Shaanxi Province, and the auxiliary materials are all purchased from the Chemical Glass Procurement and Supply Station in Shanxi Province, and all of them meet the statutory standards after identification. Before preparing traditional Chinese medicine tablets, the medicinal materials are pre-treated, and the various medicinal materials in the prescription are cleaned and processed for preparation.

[0079] Accurately weigh madder, peach kernel, nepeta ear charcoal, red peony root, angelica, Kochia scoparia, fried cocklebur, rehmannia glutinosa, forsythia, honeysuckle, Kudiding, soil Poria, saponins, platycodon grandiflorum, motherwort, peeled Stir-fried bitter almonds, white peony root, fried burdock seeds, peony bark, white fresh bark, rehmannia glutinosa, wine-fried rhubarb, honeysuc...

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Abstract

The invention discloses a preparation method of a Chinese medicinal tablet for treating skin diseases. The preparation method comprises the following steps of: mixing and crushing raw materials; sieving with a 100-mesh sieve; granulating by taking 15% starch slurry as adhesive; tabletting under the conditions that the pressure is 70-90N, the granularity is controlled at 18-20 meshes and the moisture content is controlled at 4-6%; coating by using an Opadry AMB coating solution of which the concentration is 5% under the condition that the flow is 0.25-0.28kg / min; and then, preparing the Chinese medicinal tablet under the conditions that the temperature of a tablet core is 50 DEG C and the rotating speed is controlled at 7-9 revolutions / minute. The crushing yield is 98.9%, the disintegration time is controlled at 22 minutes, and the coating qualification rate reaches 98.8%. In the prepared Chinese medicinal tablet, the dissolution rate of Chinese medicinal components is improved by 45.2%, and the bioavailability is improved to 89.7%, thereby being suitable for industrialized production. By carrying out clinical verification on patients, compared with positive control drugs, the effect taking rate and the total effective rate are obviously improved (P<0.05).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of a traditional Chinese medicine tablet for treating skin diseases. Background technique [0002] Eczema is a common itching skin disease, which has different names depending on the location of the disease, such as rubella, eczema, itchy skin, red face and nose, sores and swelling, vertigo, dry stool, etc. The pathogenesis of eczema is due to disharmony of meridians, invasion of wind, dampness, and heat, and intolerance of internal causes, accompanied by symptoms such as upset, thirst, yellow urine, red tongue, yellow greasy fur, and slippery pulse. Among them, heat evil is an important factor that damages the appearance and skin, and it is most likely to combine with wind and damp evil to attack the human skin. For example, wind-heat external wave, hot and hot in the meridian, can cause freckles; exogenous wind-heat poisonous gas can cause facial sores; T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K9/20A61P17/00A61K35/58A61K35/64A61K35/583
Inventor 史志辉
Owner 史志辉
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