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Water-soluble substrate suitable for preparing water-soluble preparations of bleomycin and homologues thereof

A technology of bleomycin and bleomycin, which is applied in the field of water-soluble matrix to achieve the effect of convenient washing and reducing waste

Inactive Publication Date: 2011-07-13
济南市皮肤病防治院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its easy hydrolysis, there is no suitable external preparation available

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Water-soluble matrix preparation:

[0036] Taking each part by weight as 1 kilogram, weigh the following components:

[0037] Polyoxyethylene (40) stearate 70 parts

[0038] Fatty alcohol polyoxyethylene ether (Pingping plus O) 30 parts;

[0039] The weighed above-mentioned components are co-melted and mixed to make a water-soluble matrix.

Embodiment 2

[0041] Water-soluble matrix preparation:

[0042] Taking each part by weight as 1 kilogram, weigh the following components:

[0043] Polyoxyethylene (40) stearate 60 parts

[0044] Fatty alcohol polyoxyethylene ether (Pingping plus O) 40 parts;

[0045] The weighed above-mentioned components are co-melted and mixed to make a water-soluble matrix.

Embodiment 3

[0047] The water-soluble matrix prepared in Example 1 was selected as a solvent and bleomycin was added to prepare a water-soluble ointment containing 0.1% or 0.2% bleomycin in terms of mass percentage.

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PUM

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Abstract

The invention discloses a water-soluble substrate suitable for preparing water-soluble preparations of bleomycin and homologues thereof. The water-soluble substrate is prepared by co-melting and uniformly mixing the following components in part by weight: 30 to 40 parts of polyoxyethylene (40) stearate and 60 to 70 parts of fatty alcohol-polyoxyethylene ether (peregal O). The invention also discloses the application of the water-soluble substrate in the preparation of a water-soluble preparation of the bleomycin, a water-soluble preparation of pingyangmycin, a water-soluble preparation of boanmycin or a water-soluble preparation of boningmycin. The water-soluble substrate does not contain water, but can be dissolved in water, so that the medicinal preparations prepared by the water-soluble substrate are convenient to wash and remove; and when the medicinal preparations are used, the user does not need to directly touch the medicinal preparations by hands, so that the waste of the medicinal preparations is reduced and the irritation to the hands is reduced.

Description

technical field [0001] The present invention relates to a water-soluble matrix, in particular to a water-soluble but water-soluble matrix and its application in the preparation of bleomycin or its homologue pingyangmycin, bleomycin or boningmycin water-soluble preparations . technical background [0002] Bleomycin, also known as bleomycin, consists of multiple components, and bleomycin is A 2 Main composition, Pingyangmycin is A 5 , Boanmycin is A 6 , Boaningmycin is acetylated Boaningmycin. [0003] The complex of bleomycin and iron intercalates into DNA, causing DNA single-strand and double-strand breaks. It does not cause RNA strand breaks. The first step of action is that the dithiacuo ring of this product is embedded between the G-C base pairs of DNA, and at the same time, the positive charge of the terminal san peptide amino acid interacts with the DNA phosphate group to untie the chain. The second step of the action is that the complex of this product and iron l...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K38/14A61K9/00A61K9/06A61P35/00A61K47/10A61K47/14
Inventor 闫军王晓东陈声利
Owner 济南市皮肤病防治院
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