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Red sage root extract sustained-release micropills and preparation method and application thereof

A technology of sustained-release pellets and extracts, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve problems such as difficult research and complex mechanism of action, and achieve the effects of expanding peripheral blood vessels, stable release, and improved blood circulation

Active Publication Date: 2011-07-06
LIVZON PHARM GRP INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the active ingredient Salvia miltiorrhiza extract in the Danshen preparation is multi-component and multi-target to play an overall therapeutic effect, and its mechanism of action is complex, which has caused certain problems for the study of the sustained-release dosage form of the Danshen extract that uses the Danshen extract as the active ingredient of the drug. difficulty

Method used

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  • Red sage root extract sustained-release micropills and preparation method and application thereof
  • Red sage root extract sustained-release micropills and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Prescription

[0037] 1.1 Pill Core Prescription

[0038] Danshen Extract 150g

[0039] 650g microcrystalline cellulose

[0040] Starch 150g

[0041]Croscarmellose Sodium 25g

[0042] Sodium carboxymethyl starch 25g

[0043] 1.2 Prescription of coating solution

[0044] Ultrafine Talc Powder 1.5g

[0045] 37.5 grams of water

[0046] Copolymer of methyl methacrylate and ethyl acrylate (trade name NE-30D )

[0047] 75.0 grams

[0048] 2. Preparation method

[0049] Weigh the prescription amount of Salvia miltiorrhiza extract, microcrystalline cellulose, starch, croscarmellose sodium and carboxymethyl starch sodium and mix evenly, add water to make soft material, extrude strips, spheronize, discharge, and put the pellets in 60 Dry at ℃, sieve, and make ball cores, and take 500 grams of ball cores with the required mesh number.

[0050] Weigh the prescribed amount of ultra-fine talc powder, water, and NE-30D to make a suspension, under magnetic stirring, the ...

Embodiment 2

[0052] Release test

[0053] Accurately weigh about 2.0000 grams of the sustained-release pellets of Example 1, sample number 20090505, put them into a rotating basket, use 900ml of freshly boiled and cooled distilled water as the medium, and conduct a dissolution test at 37.0±0.5°C and 100 rpm. Take samples at 0.5, 1, 2, 4, 6, 8, 10, and 12 hours, filter, take 5ml of the filtrate, measure UV at 282nm, the release rate reaches 40% in the first 2 hours, and 60% in 4 hours , the release rate reached 80% in 8 hours, and finally the cumulative release percentage of the sustained-release pellets reached 88.4% in 12 hours, see attached figure 1 .

Embodiment 3

[0055] 1. Prescription

[0056] 1.1 Pill Core Prescription

[0057] Danshen Extract 150g

[0058] 450g microcrystalline cellulose

[0059] Starch 150g

[0060] Croscarmellose Sodium 20g

[0061] Sodium carboxymethyl starch 20g

[0062] 1.2 Prescription of coating solution

[0063] Ultrafine Talc Powder 1.5g

[0064] 37.5 grams of water

[0065] Copolymer of methyl methacrylate and ethyl acrylate (trade name NE-30D )

[0066] 60.0 grams

[0067] 2. Preparation method

[0068] Weigh the prescription amount of Salvia miltiorrhiza extract, microcrystalline cellulose, starch, croscarmellose sodium and carboxymethyl starch sodium and mix evenly, add water to make soft material, extrude strips, spheronize, discharge, and put the pellets in 60 Dry at ℃, sieve, and make ball cores, and take 500 grams of ball cores with the required mesh number.

[0069] Superfine talcum powder, water, and NE-30D of the prescribed amount are taken by weighing to make a suspension, and under m...

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Abstract

The invention provides red sage root extract sustained-release micropills. Each sustained-release micropill consists of a pill core and a coating film, wherein the pill core comprises a red sage root extract; and the coating film comprises supermicro talcpowder and a copolymer of methyl methacrylate and ethyl acrylate. The invention also provides a method for preparing the red sage root extract sustained release micropills and application of the red sage root extract sustained-release micropills in resisting cardio-cerebrovascular disease. The red sage root extract sustained-release micropills have the advantages of having steady release rate and only needing to be taken twice a day; and the accumulative release percentage reaches 88.4 percent within 12 hours.

Description

technical field [0001] The invention relates to a sustained-release pellet of salvia miltiorrhiza extract, a preparation method and application of the pellet, and belongs to the field of pharmacy. Background technique [0002] Cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral thrombosis, hypertension and cerebral infarction are one of the most common and harmful diseases in the world today, and can also cause damage to the heart, brain, kidney and other organs, seriously threatening human health and life . [0003] Sustained-release preparations can continue to release drugs for a long time after oral administration, the release speed is slow, and the blood drug concentration is stable, so the action time can be prolonged. The drugs in the sustained-release preparations are slowly released and absorbed at an appropriate speed, and the blood drug concentration " "Peak and valley" fluctuations are small, which can avoid toxic and side effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/16A61K47/38A61P9/10A61P9/12
Inventor 胡菊华周俊苏勉诚
Owner LIVZON PHARM GRP INC
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