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Embolic material composite and preparation method thereof

A material composition and embolization technology, applied in the field of materials, can solve problems such as mass effect and patient discomfort, and achieve the effects of preventing blood recanalization, accelerating vascular endothelialization, and reducing quality

Active Publication Date: 2011-06-29
MICROPORT NEUROTECH SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of embolic material causes a huge mass effect when the aneurysm is completely embolized; and, in the life and work after treatment, due to the high quality of the embolic material, the aneurysm embolized by the polymer is produced with movement. The inertia of the patient will cause great discomfort

Method used

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preparation example Construction

[0032] The present invention also provides a preparation method of embolic material composition, comprising:

[0033] Adding polyethylene-vinyl alcohol to dimethyl sulfoxide to obtain a first solution;

[0034] adding a degradable polymer to the first solution to obtain a second solution;

[0035] A contrast agent is added to the second solution to obtain an embolic material composition.

[0036] The addition of the polyethylene-vinyl alcohol into the dimethyl sulfoxide is preferably carried out in an argon atmosphere, preferably by stirring to achieve the purpose of thorough mixing.

[0037] The adding of the degradable polymer to the first solution is preferably carried out in an argon atmosphere, preferably by stirring to achieve the purpose of thorough mixing.

[0038] According to the present invention, after the contrast agent is added to the second solution to obtain the embolic material composition, the embolic material composition is preferably put into a container,...

Embodiment 1

[0044] Add 10 g of EVOH with a number average molecular weight of 60,000 to 100 ml of DMSO, and stir for 2 hours at a temperature of 50° C. in an argon atmosphere to obtain a first solution;

[0045] Add 3 g of polylactic acid with a number average molecular weight of 150,000 to the first solution, and stir for 5 hours at a temperature of 70° C. in an argon atmosphere to obtain a second solution;

[0046] Add 30 g of tantalum powder to the second solution, stir until it is uniformly dispersed, put it into a container, seal it, sterilize it and store it.

Embodiment 2

[0048] Add 8 g of EVOH with a number average molecular weight of 65,000 to 100 ml of DMSO, and stir for 2 hours at a temperature of 50° C. in an argon atmosphere to obtain a first solution;

[0049] Add 3 g of gelatin with a number average molecular weight of 40,000 to the first solution, and stir for 3 hours at a temperature of 50° C. in an argon atmosphere to obtain a second solution;

[0050] Add 30 g of tantalum powder to the second solution, stir until it is uniformly dispersed, put it into a container, seal it, sterilize it and store it.

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Abstract

An embodiment of the invention discloses an embolic material composite and a preparation method thereof. The embolic material composite comprises polyethylene-vinyl alcohol, a degradable polymer, a contrast agent and dimethylsulfoxide. After the embolic composite is injected into an aneurysm cavity, the polyethylene-vinyl alcohol, the degradable polymer and the contrast agent are precipitated and solidified along with the diffusion of dimethylsulfoxide in blood so that an embolism body is formed, thereby achieving the aim of embolizing the aneurysm. Additionally, the embolism body forms a porous structure because of the gradual degradation of the degradable polymer, so the mass of the embolism body is greatly reduced. Therefore, the embolic material composite can reduce the total mass of the embolism body via the gradual degradation of the degradable polymer, thereby relieving the occupied effect effectively. Furthermore, the finally formed porous structure is in favor of being effectively adhered with endothelial cells, promoting cell differentiation and proliferating and quickening the endothelialization of vessels, and effectively preventing the possible blood recirculation after the embolizing.

Description

technical field [0001] The present invention relates to the technical field of materials, and more specifically relates to an embolism material composition and a preparation method thereof. Background technique [0002] Due to internal and external factors such as mechanical injury, vascular sclerosis, high blood pressure, proliferation of vascular smooth muscle cells, bacterial or viral infection, induction of venous valve disease, or blood flow impact, hemangiomas will form in arteriovenous vessels. Hemangiomas are classified into aneurysms and venous aneurysms, and among them, aneurysms with rounded convex walls that occur in the brain are called cerebral aneurysms. Cerebral aneurysms can easily induce subarachnoid hemorrhage when they rupture, leading to stroke in patients; even, 80% or more patients will die after recurrent cerebral aneurysm rupture. Therefore, embolization or closure of cerebral aneurysm as early as possible is the best cure. [0003] In the method o...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/18
Inventor 康亚红金巧蓉李雨谢志永罗七一
Owner MICROPORT NEUROTECH SHANGHAI
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