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Artificial tears including carnosine and preparation method thereof

A technology of artificial tears and carnosine, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as cataract product listing, achieve the stability of artificial tears, simplify pH adjustment and osmotic pressure adjustment, The effect of the preparation method is simple and convenient

Inactive Publication Date: 2011-06-22
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Carnosine is currently mostly limited to laboratory research, and there is no product listed as an ophthalmic drug or an active ingredient for the prevention of cataracts

Method used

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  • Artificial tears including carnosine and preparation method thereof
  • Artificial tears including carnosine and preparation method thereof
  • Artificial tears including carnosine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 Artificial tears 1 with a carnosine concentration of 0.2% by weight and its preparation method

[0065] Table 1 Prescription of artificial tears 1 with a carnosine concentration of 0.2% (weight)

[0066] Components (per 1000g)

Content

Carnosine

2.0g

Sodium bicarbonate

0.2g

Sodium chloride

8.5g

Benzalkonium chloride

0.1g

Potassium chloride

0.15g

Glucose

1.0g

Calcium chloride

0.5g

Replenish water for injection to

1000g

[0067] Take the prescribed amount of carnosine, sodium bicarbonate, sodium chloride, benzalkonium chloride, potassium chloride, glucose, calcium chloride and dissolve it with appropriate amount of water for injection, add water for injection to the full amount, stir well and pass through 0.45μm, 0.22μm Microporous membrane filtration and filling.

[0068] Thus, artificial tears 1 with a carnosine concentration of 0.2% by weight was prepared.

Embodiment 2

[0069] Example 2 Artificial tears 2 with carnosine concentration of 0.5% by weight and preparation method thereof

[0070] Table 2 The prescription of artificial tears 2 with a carnosine concentration of 0.5% (weight)

[0071] Components (per 1000g)

Content

Carnosine

5.0g

Carbomer

3.0g

[0072] Sodium dihydrogen phosphate

5.0g

Ethyl paraben

0.3g

Propylene Glycol

5.5g

Sulfite

1.0g

Replenish water for injection to

1000g

[0073] Take the prescribed amount of carbomer, add appropriate amount of water for injection to swell, and then sterilize for use; take appropriate amount of water for injection, add the prescribed amount of carnosine, sodium dihydrogen phosphate, ethyl paraben, propylene glycol, sodium sulfite to dissolve, stir well and pass 0.45μm, Filter with 0.22μm microporous filter membrane, add it to carbomer, add water for injection to full volume, stir evenly, and fill to obtain gelatinous artificial tears containing carnosine.

[0074] ...

Embodiment 3

[0075] Example 3 Artificial tears 3 with a carnosine concentration of 1% by weight and its preparation method

[0076] Table 3 The prescription of artificial tears 3 with a carnosine concentration of 1% (weight)

[0077] Components (per 1000g)

Content

Carnosine

10.0g

Hydrochloric acid (1M)

8.0g

Sodium chloride

6.5g

Replenish water for injection to

1000g

[0078] Take the prescription amount of carnosine and sodium chloride to dissolve it with water for injection, add hydrochloric acid to adjust the PH value between 7.0 and 7.5, replenish the water for injection to the full amount, use 0.45μm, 0.22μm microporous membrane for the drug solution in a hundred-level environment Filter, use automatic filling equipment to fill the medicine into a single-dose packaging container to prepare a single-dose artificial tear.

[0079] Thus, artificial tears (daily dose product without preservatives) with a carnosine concentration of 1% by weight were prepared.

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Abstract

The invention relates to artificial tears, in particular to artificial tears including carnosine, concretely, the artificial tears including carnosine comprise the following components and contents in percentage by weight: 0.2-5.0 percent of carnosine, an osmotic pressure regulator, a pH regulator and the balance of water, wherein the osmotic pressure regulator makes the mill-osmotic pressure mol concentration ratio of the artificial tears be between 0.9 and 1.1, and the pH regulator makes the pH value of the artificial tears be between 5.0 and 9.0. The artificial tears including carnosine can be used for treating dry eye syndrome, and also has a function of preventing cataract. The invention also relates to a preparation method of the artificial tears.

Description

Technical field [0001] The invention relates to an artificial tear fluid, in particular to an artificial tear fluid containing carnosine, and a preparation method of the artificial tear fluid. Background technique [0002] Dry eye syndrome is a general term, also known as keratoconjunctivitis sicca (KCS) or ophthalmoxerosis (ophthalmoxerosis), which refers to the pathological changes in the tear film of the eye that prevent the cornea and conjunctiva from getting normal moisture. The general term for a series of eye diseases that have appeared. The instability of the tear film and the damage to the ocular surface caused by the abnormality of the quality or quantity of the tear fluid, or the abnormality of the kinetics of the tear fluid, lead to symptoms such as eye discomfort. Dry eye is a common and frequently-occurring disease in ophthalmology clinics. Its typical symptoms include less tears in the eye, dry eyes, itching, burning, fatigue, blurred vision, or fluctuations in vi...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61P27/04A61P27/12
Inventor 刘继东唐海杨宇春马明欣
Owner SHENYANG XINGQI PHARM CO LTD
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