Method for extracting astragaloside IV from astragalus

Abstract

The invention relates to a method for extracting astragaloside IV from astragalus and belongs to the technical field of medicines. From an economic prospective, the convention method greatly increases production cost and period, which is unfavorable for the competition of enterprises on market. The method provided by the invention comprises the following steps: a, soaking an astragalus medicinal material in alcohol, heating, extracting and concentrating the extract to a certain volume; b, adding alcohol into the concentrate; c, adding petroleum ether, normal hexane or ethyl acetate into the solution obtained by the step b for extraction, and collecting a bottom phase; d, concentrating the lower phase till the lower phase contains no ethanol, adding alkaline solution and dehydrating for 0.5 to 10 hours at 30 to 100 DEG C; and e, adding n-butyl alcohol and one or several of ethyl acetate, normal hexane or petroleum ether for mixed extraction, collecting an upper phase, washing the upper phase, evaporating the upper phase to dryness, and crystallizing to obtain astragaloside IV. The purity of the astragaloside IV prepared by the method can reach 90 to 99 percent.

Description

A method for extracting astragaloside IV from Radix Astragali technical field The invention relates to the technical field of medicine, in particular to a method for extracting astragaloside IV from Astragalus membranaceus. Background technique Astragalus is derived from the leguminous plant Astrangaluj.membranaceuj (Fisch.) Gge.Var.mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. The main biologically active components in Astragalus include santie saponins, flavonoids and polysaccharides, etc., among which threetie saponins mainly include astragaloside IV and soybean saponin I, among which astragaloside IV has the highest content, which is the highest content of astragaloside IV. One of the main ingredients. Astragaloside IV, as an important indicator to measure the quality of Astragalus membranaceus, has various functions such as anti-inflammatory and blood pressure reduction, liver protection, tumor suppression, and free radical scavenging. Its chemic...

AI Technical Summary

Problems solved by technology

The content of astragaloside IV in Astragalus membranaceus is extremely low. At present, the extraction methods of astragaloside IV include water boiling, alcohol extraction, water extraction and alcohol precipitation, etc. Resin method or activated carbon is often used for purification, but the amount of resin loaded is small, The amount of elution solvent is large, there is waste of elution solvent, the elution time on the column is long, the production cycle is long, the product is prone to resin particle impurities, and the production equipment is huge and expensive.

The problem that this method exists makes product purity low, and yield is low and production cycle is long

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