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Procaine injection

A technology of procaine and injection, applied in the field of pharmaceutical preparations, can solve problems such as no discovery

Inactive Publication Date: 2011-05-18
天津金世制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the general anesthetics used today do not participate in human metabolism after entering the human body, and are excreted from the human body in their original form, and have little effect on the functions of human organs. So far, no anesthetics that have a damaging effect on the human brain have been found.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of small needles: take 5g of 10% procaine, 1% 0.1g xylitol and distilled water, filter through a G4 funnel, pack and sterilize.

Embodiment 2

[0019] Take 18g of procaine under aseptic conditions, put it in a container, add 1000ml of water for injection, add 1.8g of sodium carbonate to adjust the pH to 5.5-7.5, add 50g of mannitol and 20g of xylitol, and perform high-pressure injection according to the requirements of the injection. Sterilize and sterilize, add 1.5g of activated carbon, filter with a microporous membrane, pack the filtrate in 0.6ml per bottle, and use freeze-drying to obtain a yellow loose block, which is sealed.

Embodiment 3

[0021] Under sterile conditions, take 100g of procaine and 30g of xylitol and add it to 24000ml of water for injection, add 60g of sodium thiosulfate and stir for 30 minutes, add 30g of activated carbon, stir and absorb for 30 minutes, remove carbon, fine filter, potting, Sterilize to obtain the injection solution. Or take 100g of compound procaine and 30g of xylitol under aseptic conditions, add it to 24000ml of water for injection, filter through a G4 funnel, subpackage and sterilize to obtain an injection.

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PUM

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Abstract

The invention discloses a procaine injection which is prepared from the following bulk pharmaceutical chemicals: procaine, xylitol, 30-70% ethanol and polyethylene glycol 400. The preparation method of the procaine injection comprises: taking procaine of a prescription amount; dissolving the procaine with ethanol; adjusting pH value; adding the xylitol; then, adding the polyethylene glycol 400 and propylene glycol; diluting to reach the whole amount; stirring; adjusting the pH value; filtering; splitting; and sterilizing by circulated steam. The injection has stable quality and high bioavailability and is especially suitable for patients with diabetes.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, specifically, a procaine injection and a preparation method thereof. Background technique [0002] Procaine is an amide local anesthetic that can interact with the axoplasmic medial receptors of the sodium channel on the nerve cell membrane, block the influx of sodium ions, and reversibly block the impulse conduction of nerve fibers. It has the characteristics of fast action, wide diffusion, strong penetrating power, and no obvious expansion of blood vessels. Menthol is a saturated cyclic alcohol extracted from the traditional Chinese medicine Peppermint, which can interact with nerve cell membrane lipids, causing changes in the membrane lipid structure, swelling the membrane, narrowing the sodium channel of the cell membrane, reducing the influx of sodium ions, and nerve cells cannot Generate a spreading action potential, resulting in local nerve blockade. Pharmacokinetics:...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K31/245A61K47/34A61K47/16A61K47/10A61P23/02
Inventor 宋富智
Owner 天津金世制药有限公司
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