Nanometer synergistic molecularly imprinted membrane electrode for detecting forbidden drugs in weight-reducing health care product

Abstract

The invention discloses a molecularly imprinted membrane electrode for detecting forbidden drugs in a weight-reducing health care product and a method for detecting the forbidden drugs. A method for preparing the electrode ( with a schematic diagram shown in an attached figure in the specification) comprises the following steps of: selecting a functional monomer; determining the proportion of a template molecule to the functional monomer to a cross-linking agent to an initiating agent to an organic solvent for synthesizing a molecularly imprinted sol-gel; and modifying the surface of the electrode with a carbon nanotube and the sol-gel by utilizing a layer-upon-layer modifying technology. The method for detecting the trace forbidden drugs in a weight-reducing health care product comprisesthe following steps of connecting the modified electrode to an electrochemical workstation and detecting merchant weight-reducing health care products, merchant weight-reducing foods and merchant weight-reducing drugs. In the invention, the electrode has the advantages of strong specificity, high sensibility and low cost, and can reach an ng level; a basic detecting process can be completed only in 5-10 minutes; the method for electrochemically detecting the forbidden drugs in the weight-reducing health care product can be operated rapidly and simply; and the reaction execution and the resultrecording can be automatically carried out by an instrument.

Description

technical field [0001] The present invention relates to the technical field of detection of prohibited drugs in health care products for weight loss, and more specifically to the preparation of a nano-synergistic molecularly imprinted membrane electrode for detecting trace amounts of prohibited drugs in health products. The present invention also relates to the use of the molecularly imprinted membrane An electrode method for the detection of trace levels of illicit drugs in samples of weight loss supplements. Background technique [0002] Common illegal drug ingredients in the weight loss health care product market are mainly chemically synthesized appetite suppressants. Synthetic appetite suppressants are illegally added to weight loss health care products to achieve the purpose of reducing weight by acting on the central nervous system to suppress people's appetite. The U.S. Food and Drug Administration (FDA) has banned such drugs from being sold on the market as a banned...

AI Technical Summary

Problems solved by technology

[0005] 1. Gas chromatography (GC) and high performance liquid chromatography (HPLC) are commonly used methods for detecting prohibited drugs in weight loss health care products. These two methods have high sensitivity and can also solve certain selectivity problems, but these two methods , the operation is cumbersome, and the analysis process takes a long time, which cannot meet the current high-throughput detection requirements

[0006] 2. The chemiluminescence method is a new method developed in recent years. It is also used in the detection of prohibited drugs in weight loss health care products. It has high sensitivity and a small amount of samples. It can be used in conjunction with flow injection technology to realize instrument automation. , but the selectivity of the method is poor, and it cannot solve the interference problem of coexisting substances, so the results of the interference of coexisting substances are brought into the test results

[0007] 3. With the help of large-scale precision instruments such as HPLC or LC-MS combined technology, the instrument detection method for banned drugs in Mi's weight loss health products has been established. It has high sensitivity for the detection of banned drugs, but this method cannot be identified at one time. The structure of the analyte often needs to be confirmed by GC-MS, and the technical cost is high. The traditional method generally takes a long time, some even as long as several hours. The operation is complicated and cannot be used for rapid on-site detection.

[0008] 4. For the detection and analysis of prohibited drugs in weight loss health care products, the above methods generally have high detection costs, false positive results, complicated detection process, single detection, large amount of reagents, not suitable for rapid on-site detection, and large interference of coexisting substances and other shortcomings, so it cannot meet the needs of actual detection

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