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Prescription for treating migraine and preparation method and use thereof

A technology of migraine and compound preparations, applied in the field of medicine, can solve problems such as rapid recurrence of headaches, inability to take long-term or overdose, and large side effects of drugs, and achieve the effects of increasing the diameter of microvessels, improving microcirculation, and increasing cerebral blood flow

Inactive Publication Date: 2011-04-20
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, in the treatment of migraine, Western medicine mostly uses non-steroidal anti-inflammatory drugs and analgesics for symptomatic treatment, and some patients use Western medicine selective calcium channel blockers such as nimodipine and 5-hydroxytryptamine (5-HT1B / 1D ) receptors Agonist triptans such as sumatriptan and ergotamine preparations, these western medicines only temporarily relieve pain in the treatment of headache, and the headache recurs quickly after stopping the medicine, and these medicines have relatively large side effects, so they should not be taken for a long time or overdose
Meniere's syndrome (vertigo) has the characteristics of recurrent attacks. During the attack, the main treatment is to reduce the hydrops in the labyrinth and relieve the symptoms. 20% mannitol can be injected intravenously. vomiting treatment, there is no cure

Method used

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  • Prescription for treating migraine and preparation method and use thereof
  • Prescription for treating migraine and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1) Take 200 g each of Peppermint, Alisma, and Nepeta, and 100 g of Atractylodes macrocephala, add 10 times the amount of water, heat, and steam distill to extract the volatile oil. The extraction time is 1 hour, and the volatile oil and water liquid are obtained; the volatile oil is added with β-cyclodextrin Stir and clathrate to obtain a volatile oil clathrate, the solid-to-liquid ratio of β-cyclodextrin to volatile oil is 8:1 ml / g. The water liquid is filtered, and the filtrate is set aside, and the dregs are added with 6 times the amount of water to reflux and extracted twice, filtered, the obtained filtrate is combined with the water liquid after extracting the volatile oil, concentrated, and dried to obtain dry extract A;

[0017] 2) Take 400g each of Rhizoma Chuanxiong and Angelica dahurica, add 2 times the amount of ethanol, the ethanol concentration is 2% by volume, reflux extraction once, each extraction time is 1 hour, the extract is concentrated and dried to o...

Embodiment 2

[0021] 1) Take 100g each of Peppermint, Alisma, Nepeta, and Atractylodes Rhizoma, add 1600 times the amount of water, heat, and steam distill to extract the volatile oil. The extraction time is 10 hours, and the volatile oil and water liquid are obtained; the volatile oil is stirred with β-cyclodextrin, Inclusion compound to obtain volatile oil clathrate, the solid-liquid ratio of β-cyclodextrin and volatile oil is 8:1 ml / g. Filtrate the water and liquid, set aside the filtrate, add 10 times the amount of water to the dregs and reflux extract 3 times, filter, combine the obtained filtrate with the water after extracting the volatile oil, concentrate and dry to obtain dry extract A;

[0022] 2) Take 100g of Rhizoma Chuanxiong and 400g of Angelica dahurica, add 20 times the amount of ethanol, the ethanol concentration is 100% by volume, reflux extraction 5 times, each extraction time is 5 hours, the extract is concentrated and dried to obtain dry extract B;

[0023] 3) Dry extra...

Embodiment 3

[0026] 1) Take 200g of mint, 100g of Alisma, 50g of nepeta panicle, and 50g of Atractylodes macrocephala, add 100 times the amount of water, heat, steam distillation to extract volatile oil, and the extraction time is 5 hours to obtain volatile oil and water liquid; volatile oil plus β-cyclopaste After fine stirring and inclusion, the volatile oil clathrate was obtained, and the solid-to-liquid ratio of β-cyclodextrin to volatile oil was 8:1 ml / g. The water liquid is filtered, and the filtrate is set aside, and the dregs of the medicine are refluxed and extracted 3 times with 7 times the amount of water, filtered, the obtained filtrate is combined with the water liquid after extracting the volatile oil, concentrated, and dried to obtain the dry extract A;

[0027] 2) Take 800g of Rhizoma Chuanxiong and 200g of Angelica dahurica, add 10 times the amount of ethanol, the ethanol concentration is 50% by volume, reflux extraction twice, each extraction time is 2 hours, the extract i...

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Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating migraine and a preparation method thereof. The traditional Chinese medicine compound preparation comprises the following pharmaceutical raw materials: 1-20 parts of Szechuan lovage rhizome, 1-20 parts of dahurian angelica root, 1-20 parts of peppermint, 1-20 parts of oriental waterplantain rhizome, 1-20 parts of fineleaf schizonepeta herb and 1-20 parts of largehead atractylodes rhizome, and the part ratio is weight ratio. Ethanol is adopted for extracting active ingredients of the Szechuan lovage rhizome and the dahurian angelica root; and the steam distillation method is adopted for extracting volatile oil of the peppermint, the oriental waterplantain rhizome, the fineleaf schizonepeta herb and the largehead atractylodes rhizome, and water is further adopted for extracting other active ingredients. Extract solution of the six medicines are concentrated and dried; and the volatile oil is included via beta-cyclodextrin and uniformly mixed with extracts after drying, excipients are added, and a preparation is finally prepared. The medicine has good analgesic effect and can also be antagonistic to shrinkage role of PE (polyethylene) and 5-HT (5-hydroxytryptamine) to blood vessels, improve the diameter of capillary blood vessels, improve the microcirculation and effectively improve the cerebral blood flow of rats, thereby being an effective prescription for treating the migraine and Meniere's syndrome.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a prescription for treating migraine and its preparation method and application. Background technique [0002] Migraine and vertigo are one of common clinical diseases with high clinical incidence rate, but there is a lack of effective therapeutic drugs. For example, in the treatment of migraine, Western medicine mostly uses non-steroidal anti-inflammatory drugs and analgesics for symptomatic treatment, and some patients use Western medicine selective calcium channel blockers such as nimodipine and 5-hydroxytryptamine (5-HT1B / 1D ) receptors Agonist triptans such as sumatriptan and ergotamine preparations, these western medicines only temporarily relieve pain in the treatment of headache, and the headache recurs quickly after stopping the drug, and these drugs have relatively large side effects, so they should not be taken for a long time or overdose . Meniere's syndrome (vertigo) has th...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/16A61K9/20A61K9/48A61P25/06A61P1/08
Inventor 田景奎张琳荣语媚陈润泽应弘梅戚中杰徐燕刘小保
Owner ZHEJIANG UNIV
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