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Method for preparing superparamagnetic micron starch

A technology of superparamagnetic and magnetic nanoparticles, which is applied in the fields of magnetism of organic materials/organic magnetic materials, medical preparations of non-active ingredients, pharmaceutical formulations, etc., and can solve problems such as destroying porous structures and reducing starch adsorption and drug loading capacity. , to achieve the effects of simple preparation process, improved bioavailability, and reduced side effects

Active Publication Date: 2011-04-13
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The magnetic nano-starch prepared by this method uses soluble starch, which has destroyed the porous structure inside the starch, which will seriously reduce the adsorption and drug-loading capacity of the starch.

Method used

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  • Method for preparing superparamagnetic micron starch

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Preparation of Superparamagnetic Japonica Rice Starch

[0027] Accurately weigh 8.1 g of ferric trichloride hexahydrate and dissolve in 142.5 ml of deionized water, transfer to a three-necked flask, stir and heat to 70°C. Weigh 4.4 g of ferrous chloride tetrahydrate, dissolve it in 10 ml of deionized water, filter, and take 7.5 ml into a three-neck flask. Under the condition of vigorous stirring, 18 ml of concentrated ammonia water (25%, w / v) was quickly added, and after 1 min, 4.66 g of oleic acid was added dropwise, and the rapid stirring was continued at 70°C for 1 h. After the reaction, a black sol-like substance was obtained, and the resulting precipitate was separated from the reaction system by applying an external magnetic field. Wash with alcohol twice to remove excess oleic acid, and then wash with deionized water to about pH=7. Then add 160 ml of KMnO at a concentration of 10 mg / ml 4 solution, KMnO 4 The solution oxidizes the oleic acid on the surface of ...

Embodiment 2

[0034] Preparation of Superparamagnetic Tapioca Starch

[0035] Accurately weigh 8.1 g of ferric chloride hexahydrate and dissolve in 142.5 ml of deionized water, transfer to a three-necked flask, stir and heat to 70°C. Weigh 4.4 g of ferrous chloride tetrahydrate, dissolve it in 10 ml of deionized water, filter, and take 7.5 ml into a three-necked flask. Under the condition of vigorous stirring, 18 ml of concentrated ammonia water (25%, w / v) was quickly added, and after 1 min, 4.66 g of oleic acid was added dropwise, and the rapid stirring was continued at 70°C for 1 h. After the reaction, a black sol-like substance was obtained, and the resulting precipitate was separated from the reaction system by applying an external magnetic field. Wash with alcohol twice to remove excess oleic acid, and then wash with deionized water to about pH=7. Then add 160 ml of KMnO at a concentration of 10 mg / ml 4 solution, KMnO 4 The solution oxidizes the oleic acid on the surface of the mag...

Embodiment 3

[0042] Preparation of Superparamagnetic Corn Starch

[0043] Accurately weigh 7 g of ferric chloride hexahydrate and dissolve in 140 ml of deionized water, transfer to a three-necked flask, stir and heat to 50°C. Weigh 4 g of ferrous chloride tetrahydrate and dissolve it in 8 ml of deionized water, filter, and take 7 ml into a three-necked flask. Under the condition of vigorous stirring, 15ml of concentrated ammonia water (25%, w / v) was quickly added, and after 3 minutes, 3.2g of oleic acid was added dropwise, and the rapid stirring was continued at 50°C for 30 minutes. After the reaction, a black sol-like substance was obtained, and the resulting precipitate was separated from the reaction system by applying an external magnetic field. Wash with alcohol 3 times to remove excess oleic acid, and then wash with deionized water to about pH=7. Then add 100 ml of KMnO at a concentration of 8 mg / ml 4 solution, KMnO 4 The solution oxidizes the oleic acid on the surface of the mag...

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Abstract

The invention discloses a method for preparing superparamagnetic micron starch, comprising the following steps: 1) dissolving the weighed FeCl3.6H2O solid and FeCl2.4H2O solid, adding stronger ammonia water, dropwise adding oleic acid, stirring and reacting to obtain a black sol substance, and separating the obtained precipitation from a reaction system by adopting an externally applied magnetic field to obtain a magnetic fluid; 2) mixing the magnetic fluid and an enzyme preparation, and performing magnetic separation to obtain magnetic nano particles absorbed with the enzyme preparation; 3) adding deionized water into insoluble raw starch, and stirring to obtain a raw starch dispersion solution; 4) adding the magnetic nanoparticles absorbed with the enzyme preparation into the raw starch dispersion solution, and performing magnetic separation after reaction to obtain magnetic starch precipitation; and 5) drying or freeze drying the magnetic starch precipitation obtained in step 4) to obtain the superparamagnetic micron starch powder. The preparation process in the invention is simple, green and environment-friendly and no toxic reagent is utilized, thus the superparamagnetic micron starch can be utilized as a medical carrier.

Description

technical field [0001] The invention relates to magnetic starch, in particular to a preparation method of superparamagnetic micron starch. Background technique [0002] Magnetic microspheres have the characteristics of small particle size, large specific surface area, easy adsorption of other substances, and superparamagnetism. Magnetic microspheres made of biocompatible materials can encapsulate or adsorb drugs in polymer layers, so they can be used as Targeted drug carrier realizes directional drug delivery and has important application value. The drug carrier will enter the human body together with the drug, and the carrier is required to be harmless to the human body. [0003] Magnetic microspheres prepared from starch have many advantages such as non-toxicity, excretion of metabolites, biodegradability, convenient preparation, and cheap materials, and starch does not produce antigenicity of protein materials, which is more convenient for use. [0004] The existing mag...

Claims

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Application Information

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IPC IPC(8): C08L3/04C08L3/06C08L3/08C08L3/02C08K9/04H01F1/42C09C1/22C09C3/08A61K47/36
Inventor 陈国苏鹏飞
Owner HUAQIAO UNIVERSITY
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