Daidzein-entrapped PLGA nanoparticles and preparation method thereof

A daidzein and nanoparticle technology, which is applied in the field of daidzein-encapsulated PLGA nanoparticle and its preparation

Inactive Publication Date: 2011-04-13
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the dosage form of daidzein PLGA nanoparticles.

Method used

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  • Daidzein-entrapped PLGA nanoparticles and preparation method thereof
  • Daidzein-entrapped PLGA nanoparticles and preparation method thereof
  • Daidzein-entrapped PLGA nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of daidzein PLGA nanoparticles by composite method

[0030] (1) Take 2 mg of daidzein and 20 mg of lecithin in a sample bottle, add 2 mL of ethanol to the bottle, seal, shake at a constant temperature of 40°C for 48 hours, and take it out.

[0031] (2) Dry the ethanol in the bottle with nitrogen to form a complex.

[0032] (3) Take 60 mg of PLGA and dissolve it in 2 mL of dichloromethane.

[0033] (4) The complex is added to dichloromethane and stirred evenly, as the organic phase.

[0034] (5) Prepare 60 mL of 1% PVA aqueous solution as the water phase.

[0035] (6) Place the water phase under the ultrasonic probe of the ultrasonic conduction instrument, the working power is 600w, and the organic phase is slowly dripped into the water phase under the ultrasonic state; after the dripping, the ultrasonic is continued for 2 to 5 minutes.

[0036] (7) The emulsion formed by ultrasound was quickly transferred to a rotary evaporator, and dichloromethane was distil...

Embodiment 2

[0041] Example 2: The same steps as Example 1, but the lecithin 20mg is hydroxypropyl-β-cyclodextrin 140mg, ethanol is methanol, the complex is added to dichloromethane and stirred evenly. The complex uses 2% PVA aqueous solution After 0.5mL is dissolved, add it to dichloromethane, homogenize at 10000 rpm and stir evenly.

Embodiment 3

[0042] Example 3: The steps are the same as in Example 1, but the mass of lecithin is 10 mg.

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Abstract

The invention relates to daidzein-entrapped polylactic polyglycolic acid (PLGA) nanoparticles and a preparation method thereof in the technical field of nanomedicines. The nanoparticles comprise the following components in percentage by mass: 0.1 to 45 percent of daidzein, 25 to 95 percent of polylactic polyglycolic acid and 1 to 65 percent of pharmaceutic adjuvant, wherein the molecular weight of the PLGA is between 8,000 and 15,000, the polylactic polyglycolic acid is long-chain macromolecules in which the ratio of the lactic acid to glycollic acid is 50:50, and the pharmaceutic adjuvant is lecithin, cyclodextrin or polyvinyl alcohol (PVA). The daidzein-entrapped PLGA nanoparticles have the particle size of between 280 and 330 nanometers and concentrated particle size distribution, redissolved freeze-dried powder is not adhered, and the medicine loading rate of the PLGA nanoparticles is between 1 and 2 percent, and the encapsulating rate is between 80 and 84 percent.

Description

Technical field [0001] The invention relates to a preparation in the technical field of nano-medicine and a preparation method thereof, in particular to a PLGA nanoparticle containing daidzein and a preparation method thereof. Background technique [0002] For many drugs, oral administration is an economical, safe, and compliant route of administration. However, many drugs have poor bioavailability due to their poor solubility, which limits the use of drugs to a certain extent. [0003] Daidzein is a flavonoid compound with poor water-soluble and fat-soluble properties and low absorption in the gastrointestinal tract, leading to low drug bioavailability and insignificant effect. Therefore, how to improve the absorption of daidzein so that it can be used by the body is the purpose of the research and development of new dosage forms of daidzein. [0004] Nanoparticles, as a colloidal drug carrier, have significant advantages such as improving drug stability and controlling drug relea...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K47/34A61K31/352A61P3/10A61P9/10A61P39/06
Inventor 沈琦赵心怡马依然于苏甫
Owner SHANGHAI JIAO TONG UNIV
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