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Application of pedunculoside in preparing medicine for treating cerebral ischemia

A kind of technology with pelicin and cerebral ischemia, which is applied in the field of drugs for cerebrovascular system diseases, can solve the problems that the process conditions cannot meet the needs of industrial production, long cycle, high cost, etc., and achieve the purpose of inhibiting the increase of water content in brain tissue and preventing brain damage. Significant effect of ischemia, effect of reducing cerebral infarction size

Inactive Publication Date: 2012-07-04
李超生 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The deficiencies of the prior art are that highly toxic chloroform needs to be degreased and separated by silica gel column chromatography, the output is small, the cycle is long, the cost is high, the operation is complicated, and the process conditions cannot meet the needs of industrial production

Method used

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  • Application of pedunculoside in preparing medicine for treating cerebral ischemia
  • Application of pedunculoside in preparing medicine for treating cerebral ischemia
  • Application of pedunculoside in preparing medicine for treating cerebral ischemia

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Example 1: Rescue 2000g of Bing coarse powder, extract three times with 6 times 80% ethanol under reflux, extract for 2, 1, 1 hours respectively, filter, combine the filtrate, concentrate to extract form, add 6000ml of water, heat in a water bath, and stir , Let stand overnight, filter, get precipitate and filtrate. The precipitate is extracted by refluxing with 50-95% ethanol, filtered, the filtrate is concentrated, placed, filtered, and the precipitate is dried to obtain total saponins. Total saponins are crystallized with 10-100 times of 50-95% ethanol to obtain a part of wintergreen Glycosides. The filtrate was concentrated to 1000ml, cooled to room temperature, filtered, and the precipitate was washed three times with an appropriate amount of water, dried, and crystallized with 10-50 times the amount of 50-95% ethanol, and another part of the crude cinnamon glycoside was obtained, twice The prepared ilecine glycosides are combined and recrystallized with 10-100 tim...

Embodiment 2

[0023] Take the cinnamon glucoside prepared by the method of Example 1 and adopt the well-known infusion preparation method in the technical field to prepare cinnamon cinnamon glucoside sodium chloride injection and ilecine glycoside glucose injection: cinnamon cinnamome glucoside 40 mg, Sodium chloride 2.25g, made into ilex sodium chloride injection, the specification is 500ml, intravenous injection, 1 bottle each time, once a day; ilex 40mg, glucose 12.5g, made into holly Glucoside glucose injection, the specification is 500ml, intravenous injection, 1 bottle each time, once a day.

Embodiment 3

[0025] Take 20g of Peltatin Glycoside prepared according to the method of Example 1, add appropriate amount of water for injection, adjust the PH value to 7 with sodium carbonate, stir to dissolve, and then add 10-15% Manna for Injection equivalent to Peltatin Glycoside. Alcohol, sterilize and filter, determine the content, pack 1000 pieces, 20mg / piece, seal, and get ready. Intravenous injection, 40mg each time, once a day.

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Abstract

The invention discloses an application of pedunculoside in preparing a medicine for treating cerebral ischemia disease. An effective treatment dose of pedunculoside and a pharmaceutically acceptable carrier are prepared into the medicine for treating the cerebral ischemia disease, and the medicine can be pills, oral solution, injection, infusion agents, freeze-dried powder, microcapsules, capsules, or tablets. The medicines can be used for preventing and treating diseases such as apoplexy, cerebral infarction and the like.

Description

[0001] This application is a divisional application of the invention patent application entitled "Preparation Method and Application of Pelate Glycoside" with application number 200610017186.7 submitted to the State Intellectual Property Office of China on September 19, 2006. technical field [0002] The present invention relates to the field of drugs for cerebrovascular system diseases, in particular to the application of glucoside in the preparation of drugs for treating cerebral ischemia. Background technique [0003] Jiubing is the bark of Ilex rotunda Thunb., a plant in the Ilex family Ilex family. It is mainly produced in Guangxi and Guangdong provinces. It has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. For colds, tonsillitis, sore throat, acute gastroenteritis, rheumatic bone pain; external use for bruises, carbuncle furuncle sores, traumatic bleeding, burns and scalds. The chemical components mainly contain triterpenoi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7024A61P9/10
Inventor 李超生
Owner 李超生
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