a pharmaceutical composition

A composition and drug technology, applied in the field of medicine, can solve the problems of unreported application, etc., and achieve the effect of reducing the size of cerebral infarction, reducing the score of neurological function, and improving vitality

Active Publication Date: 2021-06-18
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] There is no report in the prior art about the pharmaceutical composition of lactone components, flavonoid components and organic acid components and their application in the treatment of ischemic stroke

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: pharmaceutical composition of the present invention (7+1 composition, weight ratio middle value)

[0051] Made by uniformly mixing the ingredients in Table 1:

[0052] Table 1 Pharmaceutical composition composition and content

[0053]

[0054] In this embodiment, lactone components account for 37.80% of the total weight of the composition; flavonoid components account for 61.99% of the total weight of the composition; organic acid components account for 0.21% of the total weight of the composition. Quercetin, kaempferol, epigallocatechin gallate, myricetin, isorhamnetin-3-O-rutinoside, and kaempferol-7-O-p-coumaroyl-3-O-rhamnoside The weight ratio of sugar-(1,2)-glucoside is 0.110:0.039:0.030:0.040:2.827:2.163.

Embodiment 2

[0055] Embodiment 2: pharmaceutical composition of the present invention (12+1 composition, weight ratio middle value)

[0056] Made by uniformly mixing the ingredients in Table 2:

[0057] Table 2 Pharmaceutical composition composition and content

[0058]

[0059] In this embodiment, lactone components account for 22.81% of the total weight of the composition; flavonoid components account for 77.09% of the total weight of the composition; organic acid components account for 0.10% of the total weight of the composition. The weight ratio of bilobalide and ginkgolide B is 3.176:1.084. Quercetin, kaempferol, epigallocatechin gallate, myricetin, isorhamnetin-3-O-rutinoside, kaempferol-7-O-p-coumaroyl-3-O-rhamnoside Sugar-(1,2)-glucoside, isorhamnetin, quercetin-3-O-rutinoside, quercetin-3-O-2"-(6"-p-coumaroyl)-glucose The weight ratio of the base-rhamnoside and the kaempferol-3-O-rutinoside is 0.110:0.039:0.030:0.040:2.827:2.163:0.054:3.918:2.259:2.958.

Embodiment 3

[0060] Embodiment 3: pharmaceutical composition of the present invention (17+1 composition, weight ratio middle value)

[0061] Made by uniformly mixing the ingredients in Table 3:

[0062] Table 3 pharmaceutical composition composition and content

[0063]

[0064]

[0065] In this embodiment, lactone components account for 28.67% of the total weight of the composition; flavonoid components account for 64.88% of the total weight of the composition; organic acid components account for 6.45% of the total weight of the composition. The weight ratio of bilobalide, ginkgolide B, ginkgolide A and ginkgolide C is 3.176:1.084:2.232:1.003. Quercetin, kaempferol, epigallocatechin gallate, myricetin, isorhamnetin-3-O-rutinoside, kaempferol-7-O-p-coumaroyl-3-O-rhamnoside Sugar-(1,2)-glucoside, isorhamnetin, quercetin-3-O-rutinoside, quercetin-3-O-2"-(6"-p-coumaroyl)-glucose of kaempferol-3-O-rutinoside, kaempferol-3-O-rutinoside, kaempferol-3-O-2"-(6"-p-coumaroyl)-glucosyl-rhamn...

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Abstract

The invention discloses a pharmaceutical composition, specifically a pharmaceutical composition for treating ischemic cerebral apoplexy. Based on the total weight of the composition, the composition is: lactone components, 18.1-50.9%; flavonoid components , 48.8‑81.8%; organic acid components, 0.07‑6.83%. The pharmaceutical composition of lactone components, flavonoid components and organic acid components and their application in the treatment of ischemic stroke have not been reported in the prior art. The pharmaceutical composition provided by the present invention can effectively reduce the cerebral infarction area of ​​the cerebral ischemia-reperfusion model mouse, and reduce its neurological function score, and can significantly improve the neuronal cell damage in the glucose and oxygen deprivation / hypoxia-reoxygenation neuron cell damage model. The activity of the microglia has a significant protective effect on the inflammation of LPS-induced microglial cells, is safe and effective, and can be prepared as a drug for preventing or treating ischemic stroke.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating ischemic stroke. Background technique [0002] Ischemic stroke, also known as "stroke", is an acute cerebrovascular disease. It is a group of diseases that cause brain tissue damage due to sudden blockage of blood vessels in the brain that prevents blood from flowing into the brain. The incidence of ischemic stroke accounts for 60% to 70% of the total number of strokes. It has the characteristics of high morbidity, high mortality and high disability rate, but there has been a lack of effective treatment methods. [0003] Thrombolytic therapy is currently recognized as the most effective treatment for stroke, but it has strict time window requirements (intravenous thrombolysis is limited to 4.5 hours, and arterial thrombolysis can be extended appropriately). Patients with existing hypertension, diabetes,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/365A61K31/353A61K31/352A61K31/216A61K31/192A61P9/10A61P25/00C07H17/07C07H1/06
CPCA61K31/192A61K31/216A61K31/352A61K31/353A61K31/365A61K31/7048C07H1/06C07H17/07A61K2300/00
Inventor 李萍杨华刘新光
Owner CHINA PHARM UNIV
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