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Acanthopanax extract medicament for preventing and treating cardiovascular and cerebrovascular disease and preparation process thereof

A technique for cardiovascular and cerebrovascular diseases and Acanthopanax senticosus leaves is applied in the field of extracts and preparations of medicines for treating and preventing cardiovascular and cerebrovascular diseases, and can solve the problems of lack of medicinal resources, long growth cycle of Acanthopanax senticosus, etc.

Active Publication Date: 2007-05-30
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the long growth cycle of Acanthopanax, it will inevitably lead to the shortage of medicinal resources

Method used

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  • Acanthopanax extract medicament for preventing and treating cardiovascular and cerebrovascular disease and preparation process thereof
  • Acanthopanax extract medicament for preventing and treating cardiovascular and cerebrovascular disease and preparation process thereof
  • Acanthopanax extract medicament for preventing and treating cardiovascular and cerebrovascular disease and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The leaves of Acanthopanax senticosus are removed from impurities, broken, put in the extraction tank, add 40% ethanol to reflux and extract three times, each time for 3 hours, each time the volume of ethanol is added L: the weight of Acanthopanax senticosus leaves in kg is 6: 1. Filtrate, combine the filtrates, concentrate, take the supernatant and filter it through a plate and frame filter, put it on the treated polyamide column, elute with water until the effluent is nearly colorless, and then wash it with 10% ethanol (v / v) Elution until the effluent is light yellow, discard the above eluent, and then elute with 50% ethanol (v / v), collect the eluate until the effluent is light yellow, recover the ethanol and concentrate, spray dry, that is A kind of medicine of the present invention for the treatment and prevention of cardiovascular and cerebrovascular diseases Acanthopanax leaf extract. Calculated by hyperin, the content of phenolic components is 58.6%.

Embodiment 2

[0027] After removing impurities, the leaves of Acanthopanax senticosus are broken, put them in the extraction tank, add 50% ethanol (v / v) to reflux and extract three times, each time for 2 hours, the volume of ethanol added each time L: the weight of Acanthopanax senticosus leaves kg is 11:1, filter, combine the filtrates, concentrate, take the supernatant and filter it through a plate and frame filter, put it on the polyamide column that has been treated, and wash it with water until the effluent is almost colorless, then wash it with 20 % ethanol (v / v) was eluted until the effluent was pale yellow, the above eluent was discarded, and then eluted with 60% ethanol (v / v), the eluate was collected until the effluent was light yellow, the ethanol was recovered and concentrated, Spray-dry to obtain the Acanthopanax japonicus leaf extract, which is a medicine for treating and preventing cardiovascular and cerebrovascular diseases of the present invention. Calculated by hyperin, th...

Embodiment 3

[0029] The leaves of Acanthopanax senticosus are removed from impurities, broken, put in the extraction tank, and refluxed with 80% ethanol (v / v) to extract three times, each time for 1 hour, the volume of ethanol added each time L: the weight of Acanthopanax senticosus leaves kg 12:1, filter, combine the filtrates, concentrate, take the supernatant and filter it through a plate and frame filter, put it on the polyamide column that has been treated, elute with water until the effluent is almost colorless, and then add 30% Elute with ethanol (v / v) until the effluent is pale yellow, discard the above eluate, then elute with 70% ethanol (v / v), collect the eluate until the effluent is light yellow, recover and concentrate the ethanol, spray After drying, the extract of Acanthopanax japonicus leaves, which is a medicine for treating and preventing cardiovascular and cerebrovascular diseases of the present invention, is obtained. Calculated by hyperin, the content of phenolic compon...

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Abstract

The invention provides a Chinese medicinal preparation of acanthopanax root leaf extract for treating and preventing cardiovascular and cerebrovascular diseases and its preparing process, wherein the acanthopanax root leaf extract comprises quercetin, quercetin, globularicitrin, hyperin, chlorogenic acid and dicaffeoylquinate. Based by hyperin, the content of phenol constituents in the extract is not lower than 50%.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a medicine for treating and preventing cardiovascular and cerebrovascular diseases, acanthopanax leaf extract and a preparation method. technical background [0002] Cardiovascular and cerebrovascular diseases are one of the three difficult diseases that endanger human health, and their morbidity and mortality have risen to No. 1 in some countries. Therefore, the development of cardiovascular drugs is one of the major issues faced by medical workers. Although many cardiovascular drugs that have been successfully developed at present have good therapeutic effects, their clinical application is limited due to the strong toxic and side effects of the drugs themselves. Therefore, the current focus of cardiovascular drug research is to find preventive and therapeutic drugs with less toxic side effects. [0003] Acanthopanax is a plant belonging to Araliaceae. It is one of ...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61P9/00C07D311/30C07H1/08C07C67/48C07C51/42C07B63/00A61K127/00
Inventor 刘志强宋凤瑞刘淑莹
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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