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Nasal spray for treating acute cerebral apoplexy and preparation method thereof

A cerebral apoplexy and acute technology, which is applied in the field of nasal spray for the treatment of acute cerebral apoplexy and its preparation, can solve the problems of changing the permeability of the blood-brain barrier, unfavorable portability for rehabilitation, and high environmental requirements for injection.

Inactive Publication Date: 2021-08-06
WUXI JIMIN KEXIN SHANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, it has the characteristics of aromatic and resuscitating drugs. Borneol and L-borneol are small molecule terpenoids, which are resuscitating and refreshing drugs. They have the effect of "walking up" and can change the permeability of the blood-brain barrier. , to promote the passage of drugs through the blood-brain barrier, turmeric has very important pharmacological activity, and has an inhibitory effect on human platelet aggregation, but the daily injection environment requires high requirements, which is not conducive to carrying and later rehabilitation use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take turmeric 30g, gardenia 30g, add about 1500ml of water for distillation, collect 500ml of distillate; add 7g of musk to the above distillate, add 500ml of distilled water for distillation, collect 500ml of distillate, and set aside. Take 1g of borneol, add 5g of polysorbate-80 (for injection), grind well, add to the distilled liquid, add 4g of sodium chloride, mix well, sterilize and filter, and divide into packages.

Embodiment 2

[0037] Take turmeric 30g, gardenia 30g, add about 1500ml of water for distillation, collect 500ml of distillate; add 3g of musk to the above distillate, add 500ml of distilled water for distillation, collect 500ml of distillate, and set aside. Take 1g of borneol, add 6g of polyethylene glycol 300 (for injection), grind well, add to the distilled liquid, add 4g of glucose, mix well, sterilize and filter, and divide into packages to obtain.

Embodiment 3

[0039] Take turmeric 30g, gardenia 30g, add about 1500ml of water for distillation, collect 500ml of distillate; add 3g of musk to the above distillate, add 500ml of distilled water for distillation, collect 500ml of distillate, and set aside. Take 2g of borneol, add 5g of polysorbate-80 (for injection), grind well, add to the distilled liquid, add 4g of sodium chloride, mix well, sterilize and filter, and pack to obtain.

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PUM

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Abstract

The invention relates to a nasal spray for treating acute cerebral apoplexy and a preparation method thereof, and the nasal spray is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 6-9 parts of musk, 20-40 parts of radix curcumae, 20-40 parts of cape jasmine and 0.5-2 parts of borneol.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a nasal spray for treating acute cerebral apoplexy and a preparation method thereof. Background technique [0002] Cerebral stroke, also known as stroke or cerebrovascular accident, is one of the common diseases and high-risk diseases in modern society. Its clinical diagnosis is cerebral thrombosis, cerebral hemorrhage, cerebral infarction and other diseases. Studies have shown that there are various causes of stroke, and some primary strokes are mainly caused by poor living habits of patients. With the development of the times and the advancement of medical technology, more and more studies have confirmed the correlation between stroke and other diseases: relevant investigations have shown that moderate alcohol intake has a certain protective effect on cardiogenic stroke, but excessive Alcohol intake can cause stroke; stroke patients are accompani...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/12A61K47/02A61K47/26A61P7/02A61P9/10A61P25/00A61K31/045A61K35/55
CPCA61K35/55A61K36/9066A61K31/045A61K36/744A61K9/0043A61K9/12A61K47/26A61K47/02A61P25/00A61P9/10A61P7/02A61K2236/331A61K2300/00
Inventor 甘国峰夏鹏添吴幸冬邹晓丹唐本俊张鹤
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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