Hemostatic bacteriostatic biological dressing and preparation method thereof

Abstract

The invention provides hemostatic bacteriostatic biological dressing and a preparation method thereof. Nano silver and hemostatic medicament are uniformly distributed in a spongy or film-like biological dressing matrix made of a biological material, wherein the weight of the nano silver is 0.01 to 3 percent of the weight of the biological material, and the weight of the hemostatic medicament is 0.1 to 10 percent of the weight of the biological material. The method for preparing the spongy biological dressing comprises the following steps of: soaking the freeze-dried sponge into silver nitrate solution to prepare nano silver-carrying biological sponge at a high temperature under a high pressure, and soaking the nano silver-carrying biological sponge into solution containing the hemostatic medicament to obtain the spongy biological dressing by freeze drying. The method for preparing the film-like biological dressing comprises the following steps of: preparing biological material solution containing silver nitrate into nano silver-carrying solution at a high temperature under a high pressure, adding the hemostatic medicament into the cooled nano silver-carrying solution, casting the mixture to form a film, and drying the film at room temperature to obtain the film-like biological dressing. The hemostatic bacteriostatic biological dressing has the characteristics of safety, no toxicity, good biocompatibility and degradability and obvious bacteriostatic and hemostatic effects; and the preparation method is simple and has strong operability and low cost.

Description

technical field [0001] The invention relates to a biomedical dressing and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] As an important organ of the human body, the skin controls body temperature, prevents infection and loss of body fluids, and maintains a stable internal environment. After skin injury due to wounds, abrasions, burns and ulcers, etc., it is easy to cause bacterial infection, loss of body fluids and various complications. When treating this kind of human skin injury with tissue loss, dressings are usually used to protect the wound to prevent infection and dehydration of the wound, maintain a moist environment conducive to treatment at the wound, improve the therapeutic effect, and promote wound healing. [0003] An ideal dressing should have the following characteristics: (1) safe, non-toxic, and non-irritating; (2) good biocompatibility, preferably degradable; (3) capable of maintaining...

AI Technical Summary

Problems solved by technology

This biological sponge utilizes the antibacterial activity of nano-silver and does not produce drug-resistant bacteria, which improves the antibacterial ability, but this biological sponge can only stop bleeding with the help of the hemostatic property of the biological material itself, so its hemostatic ability is very weak; Moreover, it is prepared by irradiating the biological sponge containing silver ions by ultraviolet rays. When the sponge is thick, due to the limited penetration ability of ultraviolet rays, the generation of nano-silver in the center of the sponge will be affected, thereby affecting the antibacterial effect of this biological sponge. ability

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