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Microemulsion for animals and preparation method thereof

A microemulsion and solvent technology, applied in the field of veterinary medicine, can solve the problems of affecting drug absorption and curative effect, reducing diet, unwillingness to take food, etc., and achieve the effects of helping absorption and utilization, reducing irritation and reducing pain.

Inactive Publication Date: 2011-01-19
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when the preparation is developed into a liquid preparation, it is mostly developed into a solid preparation, such as a premix for mixing feed, and a large amount of organic solvent is often required to be added when it is developed into a liquid preparation, especially when preparing a high-concentration liquid preparation. All organic solvents will be used, and these additional ingredients often cause certain adverse reactions
All of its solvents such as currently commercially available tilmicosin injections are propylene glycol, which often causes certain adverse reactions; nicarbazine, hainanmycin sodium and salinomycin sodium all have good anticoccidial effects, but Because the raw material itself is difficult to dissolve in water, the commercially available preparations only have premixes, and premixes are a dosage form specially used for mixed feeding dosage forms. When the animal body is in a disease state, its diet will be significantly reduced, or even unwilling to feed. Food intake, thus affecting the absorption of drugs and the exertion of curative effect

Method used

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  • Microemulsion for animals and preparation method thereof
  • Microemulsion for animals and preparation method thereof
  • Microemulsion for animals and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 2

[0032] Embodiment 2 prepares the water-insoluble nicarbazine into a microemulsion, which can realize drinking water administration, and compares the curative effect of using nicarbazine premix to carry out mixed feeding administration all the time, and the result nicarbazine microemulsion is more The high anticoccidial index value of carbazine premix indicates that nicarbazine prepared into microemulsion can be administered in drinking water better than premix mixed with feed.

Embodiment 3

[0033] Example 3 After preparing tilmicosin into a microemulsion, its antibacterial effect in vitro is stronger than that of tilmicosin injection, and the particle size is small and evenly distributed.

[0034] After Example 4 and 5 prepared microemulsions of hainanmycin sodium and salinomycin sodium, its anticoccidial index was higher, which was moderately effective against coccidia, indicating that it had a better effect on treating coccidia; preparation The microemulsion has small particle size and uniform distribution.

[0035] In order to make the present invention easier to understand, the present invention will be further described below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The specific experimental methods not mentioned in the following examples are generally carried out according to conventional experimental ...

Embodiment 1

[0036] Example 1 Preparation and properties of 2% berberine sulfate microemulsion

[0037] Preparation of 1.2% Berberine Sulfate Microemulsion

[0038] Berberine Sulfate 2%W / V

[0039] Polyoxyethylene Octylphenol Ether 15%W / V

[0040] 1,2-Propanediol 7.5%W / V

[0041] Ethyl Oleate 25%W / V

[0042] Vitamin E 3%W / V

[0043] Water for injection to 100% of the total amount

[0044] 1) Take 150g of polyoxyethylene octylphenol ether and 75g of 1,2-propanediol and mix evenly to obtain a mixed solution, add 250g of ethyl oleate at 70±5°C to obtain a mixed solution a;

[0045] 2) Take 20 g of berberine sulfate and add it to the mixed solution a, and stir evenly to obtain the mixed solution b;

[0046] 3) Add the mixed solution b dropwise to the water for injection while stirring, and disperse and emulsify through a high-shear dispersing and emulsifying machine (speed 5000-8000rpm) for 60 minutes to obtain colostrum, and place the colostrum in a high-pressure homogenizer (model:...

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Abstract

The invention discloses microemulsion for animals and a preparation method thereof. The microemulsion for animals comprises effective components and auxiliary solvents, which are 1 to 30 percent of effective components, 10 to 20 percent of surfactant, 5 to 10 percent of cosurfactant, 10 to 25 percent of oil phase, and the balance of water based on the total amount of 100 percent. The microemulsion prepared by the method has the advantages of small grain sizes, narrow distribution range, uniform grain distribution and good stability, has better curative effect compared with conventional preparation, and can be used for preparing medicament which is widely used in clinical veterinarian.

Description

technical field [0001] The invention relates to the application of an emulsification technology in the preparation of veterinary medicine, in particular to a microemulsion for veterinary use and a preparation method thereof, belonging to the field of veterinary medicine. Background technique [0002] Veterinary medicine has its particularity in clinical application. For example, in order to improve efficiency, veterinary medicine usually requires group administration. Under the existing technical conditions, there are mainly two kinds of mixed feeding and mixed drinking methods for animal groups. During mixed feeding, water-insoluble drugs exist in the digestive tract in the dispersed state of larger particles or droplets, so that the drugs and The contact area of ​​the digestive tract is relatively small, and its bioavailability is often small, resulting in waste of drugs. When veterinary drugs are used in groups, drinking water is the most convenient way. If the drug is m...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/4375A61K31/505A61K31/706A61K31/7048A61K31/351A61P33/02A61P31/04
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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