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Bone grafting material of gradient porous beta-TCP with bioactivity and anti-infection effect, preparation method and application thereof

A gradient porous, bioactive technology, applied in the field of medicine and biology

Inactive Publication Date: 2010-11-17
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature report on the hypothesis that using gradient porous β-TCP compound antibiotics and BMP-2 to construct anti-infective active artificial bone and repair infected bone defects

Method used

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  • Bone grafting material of gradient porous beta-TCP with bioactivity and anti-infection effect, preparation method and application thereof
  • Bone grafting material of gradient porous beta-TCP with bioactivity and anti-infection effect, preparation method and application thereof
  • Bone grafting material of gradient porous beta-TCP with bioactivity and anti-infection effect, preparation method and application thereof

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Embodiment 1

[0034] 1. Design and construction of gradient porous β-TCP

[0035] Design different pore sizes in the same cylindrical β-TCP (micro pore size, 100 μm, porosity 60%) and different spatial distribution (1. Micro pore core columnar area distribution, large pore size Peripheral columnar area distribution; 2. Reverse distribution; 3. The internal and external structure of the gradient porous β-TCP with micropores and large pores distributed in phases, using the Unigraphics software of CAD to convert the data into STL format files and input them into the laser rapid prototyping machine (Provided by the School of Mechanical and Power Engineering, Shanghai Jiaotong University), to manufacture gradient porous β-TCP resin molds. The β-TCP powder is prepared into a slurry and filled into the mold, and the gradient porous β-TCP is prepared by hot die-casting technology. The internal structure is observed under a solid microscope, and the measurement data is compared with the CAD model d...

Embodiment 2

[0045] Please see Figure 2A , Figure 2AIt is a schematic structural diagram of a bone graft carrier of gradient porous β-TCP. The bone graft carrier includes a central part 1 and a peripheral part 2, the central part 1 is a medullary core columnar structure, and the peripheral part 2 is a cylindrical structure. The central part 1 of the bone graft carrier has a length of 20 mm and a long diameter of 2 mm, and a peripheral part 2 has a length of 20 mm and a long diameter of 10 mm. Please see Figure 2B , Figure 2B It is a schematic cross-sectional view of a bone graft carrier of gradient porous β-TCP, the central part 1 is provided with small micropores 11, the long diameter of the small micropores is 6 μm, and the porosity of the small micropores is 10% (the pores of the small micropores Ratio: the percentage of the volume of small micropores to the volume of the bone graft carrier). Peripheral part 2 is provided with macropore 21, and the pore long diameter of macropor...

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Abstract

The invention relates to a bone grafting material of gradient porous beta-TCP with bioactivity and an anti-infection effect. The bone grafting material consists of anti-infection medicaments, BMP-2 and beta-TCP. The invention also provides a method for preparing the bone grafting material of the gradient porous beta-TCP with the bioactivity and the anti-infection effect. The method comprises the following steps of: constructing the gradient porous beta-TCP; and compounding the gradient porous beta-TCP with the anti-infection medicaments and the BMP-2. The invention also provides the application of the bone grafting material. The grafting material has the advantages that: different structures are manufactured in the same ceramic by a manufacturing process of constructing a gradient porous bioceramic with the bioactivity and the anti-infection effect; the BMP-2 and antibiotics are compounded in the same material separately; and the physical and chemical properties of the material are ensured to be free from influence and the co-existence of two active substances are ensured, so that a good osteogenic active protein and a medicament sustained-release effect are achieved.

Description

【Technical field】 [0001] The invention relates to the technical field of medicine and biology, in particular to a gradient porous β-TCP bone grafting material with biological activity and anti-infection effect and its preparation method and application. 【Background technique】 [0002] With the development of society, there are more and more open fractures combined with large bone defects caused by traffic accidents and trauma. How to deal with these contaminated or even infected bone defects and fractures has always been a thorny issue for orthopedic surgeons. Traditionally, one-stage debridement and systemic anti-infection treatment are used. After the infection is confirmed to be controlled, the second-stage bone grafting is used to repair bone defects and internal fixation of fractures. In this way, the treatment cycle is long, and the application of intravenous antibiotics during the period will cause complications such as flora imbalance, and long-term bed rest will al...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/54A61L27/56A61K38/18A61P19/08A61P31/04A61P31/06A61P35/00A61K31/7036A61L27/10
Inventor 李海赵黎孙效棠
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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