Method and device thereof for desorption ionization

Abstract

The invention relates to a method and a device thereof, which adopt a mode of rising the temperature gradually under normal pressure to carry out desorption ionization in sequence on mixed objects to be tested on the solid surface and carry out continuous and multiple data acquisition in the process of desorption ionization gradually. The invention leads the objects to be tested with different thermal desorption capabilities to be desorbed out of the surface of the solid object to be tested by rising the temperature of at least one part of samples gradually, thus providing a means for pre-separating mixed samples so as to reduce the difficulty for subsequent mass spectrometric detection. Simultaneously, the invention acquires mass spectrometric data for multiple times for objects to be tested with various boiling points in the process of rising temperature so as to lead the objects to be tested with low boiling point not to be consumed completely quickly due to high temperature, thus improving the detection efficiency of the objects to be tested with lower boiling points.

Description

technical field [0001] The invention relates to mass spectrometry technology, in particular to a desorption ionization method and device for ion analysis under normal pressure. Background technique [0002] With the wide application of liquid chromatography-mass spectrometry systems in the analysis of complex mixtures, ion sources working under atmospheric pressure, such as electrospray ionization sources and atmospheric pressure chemical ionization sources, have played an important role in the fields of food safety, environmental protection and national security. . However, a large amount of time in the analysis process is spent in the pretreatment process before the sample is introduced into the analysis system, which hinders the real-time and rapid operation of these analysis techniques in various industrial fields. This problem has been accompanied by some cutting-edge direct analysis methods such as desorption electrospray ionization (Desorption Flectro spray Ionizatio...

AI Technical Summary

Problems solved by technology

[0005] However, since the separation step is omitted before ionization of the complex mixture, the probability of overlapping mass spectrum peaks of different components is greatly increased, which brings certain difficulties to the analysis of the spectrum

Take an ionization method that involves thermal desorption using a heated gas as an example. When the heating temperature is set high, the components of the mixture will be desorbed simultaneously, resulting in congestion of the mass spectral peaks of the components.

At the same time, for components that can be desorbed only at a lower temperature, a higher desorption temperature will quickly consume the sample, thus affecting the analysis efficiency of the mass spectrometer for this component

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