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Combination method of polymer carbon nanotube chromatographic column and ion chromatography single pump column switching technology

A technology for switching ion chromatography columns and single-pump columns, which is applied in the field of ion chromatography single-pump column switching, can solve problems such as long retention time and limited application range, and achieve the effects of accelerating analysis speed, saving analysis time, and simplifying equipment

Inactive Publication Date: 2010-10-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the pretreatment columns generally used for ion chromatography column switching are usually ion-pair chromatography and ion-exclusion chromatography. General purpose, shorter retention time pretreatment columns make up for this shortfall

Method used

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  • Combination method of polymer carbon nanotube chromatographic column and ion chromatography single pump column switching technology
  • Combination method of polymer carbon nanotube chromatographic column and ion chromatography single pump column switching technology
  • Combination method of polymer carbon nanotube chromatographic column and ion chromatography single pump column switching technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the making process of polymer carbon nanotube composite chromatographic filler is as follows, and its steps are:

[0034] (1) Synthesize 1.8 μm monodisperse polystyrene seed by dispersion polymerization method earlier, monomer concentration is 20%, stabilizer concentration is 3%, initiator consumption is 4% of monomer, and reaction medium is 95% ethanol aqueous solution, The reaction temperature was 70°C, the stirring speed was 250 rpm, and the reaction time was 24 hours.

[0035] (2) 50 mg of multi-walled carbon nanotubes were oxidized with 200 mL of concentrated sulfuric acid / concentrated nitric acid=3:1 (v / v) mixed acid solution, ultrasonicated at 35° C. for 6 hours, washed until neutral and then dried. Then, monodisperse polystyrene-divinylbenzene-carbon nanotube composite microspheres with a crosslinking degree of 55% were prepared by seed swelling method. The concentration of the monomer is 10%, the content of carbon nanotubes accounts for 1% of the...

Embodiment 2

[0037] Example 2: The specific detection steps of polymer carbon nanotube composite chromatography and ion chromatography single-pump column switching are as follows:

[0038] 1) Set the system according to figure 1 Well connected: the pump 1 is connected to the eluent generator 2, then the eluent passes through the six-way valve 3, connects the guard column 12 and the analysis column 13, passes through the suppressor 6, enters the detector 7 for detection, and then passes through the ten-way valve 4 is connected with the pretreatment column 11, and finally enters the waste liquid bottle 10. A 200 μL quantitative loop 5 is connected to the ten-way valve 4 , and the entire system is protected by nitrogen gas, 14 is a nitrogen cylinder, and a concentration column 8 is connected to the six-way valve 3 . After pump 1 was filled with mobile phase, it was turned on at a flow rate of 0.5 mL / min. The nitrogen gas 14 for protection is opened to a pressure of about 5 psi. Detector 7 ...

Embodiment 3

[0044] Embodiment 3: This embodiment is to analyze seven kinds of common inorganic anion mixed standard samples with column switching technology

[0045] Instruments used: ion chromatograph; chromatographic pump; conductivity detector; chromatographic workstation; one six-way valve; one ten-way valve; high-purity nitrogen cylinder; analytical column; guard column; enrichment column; 200 μL injection volume; electrochemical Self-regenerating suppressor.

[0046] Pretreatment column: use the polymer carbon nanotube composite filler in Example 1 to fill in a 4.6×150mm stainless steel column.

[0047] Eluent: H 2 O, KOH eluent generator concentration: 18mM, suppressor current: 90mA, flow rate 0.65mL / min.

[0048] Analysis steps:

[0049] (1) Baseline surveying and mapping

[0050] The eluent is pumped into the chromatographic separation column to achieve equilibrium, and the eluent output from the chromatographic separation column is converted into an electrical signal by the ...

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Abstract

The invention relates to a combination method of a polymer carbon nanotube chromatographic column and an ion chromatographic column switching technology, which is carried out in an ion chromatography single pump column switching system and characterized by adopting the polymer carbon nanotube chromatographic column for carrying out the on-line pretreatment on a sample, and combining with the ion chromatography single pump column switching technology, and the analysis steps sequentially comprises the steps of surveying and mapping a baseline, loading the sample to a quantitative ring, eliminating a matrix, enriching target ions and separating and analyzing the target ions. Compared with the traditional column switching system, instruments and equipment required for the system are simpler, the reagent consumption is reduced, the analysis time is shortened, and the surplus sample pretreatment steps are unnecessary, thereby increasing the range of applicable samples and being applicable to on-line high-throughput analysis. The combination method has low cost, simple production process and excellent performances, and can be effectively used for separation and analysis of a variety of organic compounds, including organic solvents, organic acids, organic acid salts and the like.

Description

technical field [0001] The invention relates to an ion chromatography single-pump column switching technology combined with a polymer carbon nanotube chromatographic column, in particular to a simplified ion chromatographic column switching using a polymer carbon nanotube chromatographic column as a sample online pretreatment technology. Background technique [0002] As a classic sample pretreatment technology, column switching technology is widely used in online elimination of complex matrix, enrichment of samples, and multidimensional chromatographic separation. In the field of ion chromatography, column switching technology is often used to eliminate high-concentration matrix interferences when analyzing trace ions. Because too high matrix concentration often contaminates the ion chromatography column, and the matrix peak easily covers the target ion peak; in addition, because the target ion concentration is too low, the target peak cannot be separated from the impurity ...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 钟莺莺朱岩
Owner ZHEJIANG UNIV
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