Components of compound formula of Chinese medicament active parts, preparation process thereof and anti-diabetic use thereof
A technology of effective parts and effective components, applied in the field of compound prescription composition, preparation process and anti-diabetic application of effective parts of traditional Chinese medicine
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Embodiment 1
[0039] Example 1. Coptis Rhizoma Alkaloid Extract
[0040] 1.1 1.25kg Coptidis rhizome coarse powder, add 20L 70% ethanol each time to reflux for 1 hour, extract 2 times in total, combine the extracts, concentrate at 60°C to a relative density of 1.24 (60°C) concentrate, add appropriate amount of water to dilute the concentrate to 3.5L, add concentrated hydrochloric acid dropwise to the aqueous solution until no precipitation occurs (about 65ml of concentrated hydrochloric acid is required), shake well, and let it stand overnight; filter, and wash the solid powder with twice the amount (volume / weight, ml / g) of water twice , drained; the solid powder was dried under reduced pressure at 60° C. to obtain 98 g of Coptidis rhizome alkaloid extract with a yield of 7.84%.
[0041]1.2 Coptidis Coptidis powder 1.25kg, add 6.25L 80% ethanol each time to reflux for 1 hour, extract twice in total, combine the extracts, concentrate at 56°C to a relative density of 1.20 (56°C) concentrate, ...
Embodiment 2
[0044] Example 2. Astragalus saponin extract
[0045] 2.1 Astragalus powder 3.0kg, add 30L of 70% ethanol to reflux for 2 hours each time, extract 3 times in total, combine the extracts, concentrate at 60°C until there is no alcohol smell, add 5 times the amount (volume / volume) of water to dissolve, filter, The filtrate was passed through a prepared D4020 macroporous adsorption resin column (1.4kg), washed with water until it was colorless, and then eluted with 80% ethanol until the eluate was free of saponin. The eluate was combined and concentrated at 60°C Concentrate to a relative density of 1.3 (60° C.); dried under reduced pressure into powder to obtain 43.5 g of astragaloside extract with a yield of 1.45%.
[0046] 2.2 Astragalus coarse powder 3.0kg, add 15L of 80% ethanol to reflux for 2 hours each time, extract 3 times in total, combine the extracts, concentrate at 60°C until there is no alcohol smell, add 5 times the amount (volume / volume) of water to dissolve, filter...
Embodiment 3
[0049] Embodiment 3. Honeysuckle polyol extract
[0050] 3.1 Honeysuckle coarse powder 1.5kg, add 30L water to decoct for 0.5 hours each time, extract twice in total, combine the extracts, concentrate at 60°C to a relative density of 1.0 (60°C) concentrate, add an equal volume of 95% ethanol while stirring , placed overnight; filtered, the precipitate was washed with dilute alcohol, the washing liquid was combined with the filtrate, concentrated at 60°C to a relative density of 1.0 (60°C), and passed through a pre-served AB-8 macroporous adsorption resin column (1.8 kg), washed with water until the eluate was evaporated to dryness without residue, the eluate was combined, concentrated at 60°C to a concentrated solution with a relative density of 1.0 (60°C); then spray-dried into powder, and 372.3g of polyol was obtained; the yield was 24.82%.
[0051] 3.2 Honeysuckle coarse powder 1.5kg, add 30L water to decoct for 0.5 hours each time, extract twice in total, combine the extr...
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