A pharmaceutical composition for treating hyperlipidemia and atherosclerosis

A technology for atherosclerosis and hyperlipidemia, which is applied in the fields of drug combination, active ingredients of heterocyclic compounds, drug delivery, etc., can solve the problems of lack of controlled research, poor controllability of preparation quality, and unclear drug effect material basis, etc. The effect of regulating hyperlipidemia, reducing the area of ​​fatty plaque, treating hyperlipidemia and atherosclerosis

Active Publication Date: 2022-02-25
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are problems such as unknown substance basis of drug efficacy, poor controllability of preparation quality, and lack of controlled studies in most cases.

Method used

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  • A pharmaceutical composition for treating hyperlipidemia and atherosclerosis
  • A pharmaceutical composition for treating hyperlipidemia and atherosclerosis
  • A pharmaceutical composition for treating hyperlipidemia and atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0069] Weigh 200g of kudzu root, 100g of Radix Astragali and 100g of Cortex Mori, add 8 times the amount of water, soak for 30 minutes, decoct and extract twice, each decoction time is 2 hours, combine the two extracts, filter, reduce Concentrate under pressure to a relative density of 1.27 (55°C), dry and pulverize the thick paste to obtain the extract.

preparation Embodiment 2

[0071] Weigh 100g of kudzu root and 200g of astragalus, add 10 times the amount of water, soak for 30 minutes, decoct and extract twice, each decoction time is 1.5 hours, combine the two extracts, filter, and concentrate under reduced pressure to relative density 1.26 (55°C), the thick paste was dried and pulverized to obtain the extract.

preparation Embodiment 3

[0073] Preparation of Puerarin

[0074] Put 800g of kudzu root medicinal material, add 8 times the amount of 50% ethanol solution, heat and reflux to extract twice, each time for 1.5h, combine the extracts and filter, recover the ethanol from the filtrate under reduced pressure, continue to concentrate under reduced pressure to 800ml, and load the concentrated extract on AB-8 macroporous resin, statically adsorbed for 3 hours, washed with deionized water until colorless, and then eluted with 70% ethanol of 4 times the column volume, collected the 70% ethanol eluate, and concentrated under reduced pressure. The above-mentioned concentrated extract was separated by silica gel column chromatography, gradient eluted with a mixed solution formed of dichloromethane and methanol at a volume ratio of 1:0 to 0:1, and detected by thin layer chromatography, and the collected puerarin-containing fractions. The above fractions of puerarin were separated and purified by Sephedex LH-20 gel ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating hyperlipidemia and atherosclerosis. The pharmaceutical composition comprises: active components, the active components are puerarin, daidzin, genistin, soybean Aglycone, Actascoisoflavone Glucoside, Astragaloside II, Astragaloside IV, Formononetin, Mulberry A, Moranginin, Scopoletin, Sanggenone C, 1-deoxynojirimycin, Pueraria polysaccharide , a combination of two or more of Astragalus polysaccharide and Morus alba polysaccharide; and a pharmaceutically acceptable carrier. The pharmaceutical composition of the present invention can reduce the fat plaque area in the aorta of apoE- / -transgenic mice of atherosclerosis model, has the effect of regulating hyperlipidemia in mice, and can treat hyperlipidemia and atherosclerosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hyperlipidemia and atherosclerosis, a preparation method and application thereof. More specifically, the present invention relates to a compound pharmaceutical composition of active ingredients in Pueraria Radix, Radix Astragali and Cortex Mori, and its use in the preparation of medicines for treating hyperlipidemia and atherosclerosis. Background technique [0002] Atherosclerosis (AS) is a chronic arterial disease that can cause coronary heart disease, myocardial infarction and other cardiovascular and cerebrovascular diseases as well as stroke. frequently-occurring disease. In developed countries and some developing countries, the incidence of atherosclerotic cardiovascular disease is increasing year by year, and it has become the underlying disease of many common diseases of middle-aged and elderly people, known as the "number one killer". AS lesions mainly occur in the intima of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K36/488A61K36/605A61K31/352A61K31/7048A61K31/7034A61K31/37A61K31/445A61P3/06A61P9/10
CPCA61K31/352A61K31/37A61K31/445A61K31/7034A61K31/7048A61K31/715A61K36/481A61K36/488A61K36/605A61K2236/51A61K2236/39A61K2236/331A61K9/08A61K9/20A61K9/48A61K31/365A61K31/435A61K31/7028A61P3/06A61P9/10
Inventor 黄成钢李志雄高羽田小亭孙兆林陈明苍胡培刘欢徐洲
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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