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Footbath effervescent tablet for improving rheumatic arthritis

A technology for rheumatoid arthritis and effervescent tablets, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc. Active ingredients cannot be dissolved quickly and fully, etc.

Inactive Publication Date: 2010-09-15
GUANGDONG JIANDA LIGHTING ELECTRICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current commercially available medicated bath pedicure products are all powder and bagged dosage forms, which are directly pulverized from the drug, and the active ingredients of the drug are slowly dissolved, especially at the water temperature acceptable to the human body. reduced bioavailability
[0004] In order to solve the technical problem that the effective ingredients of the medicine cannot be fully dissolved at the water temperature acceptable to the human body, the patent application published as CN1947684A discloses a "Muzu effervescent tablet", which comprises 20% of the total mass -40% organic acid, 20-40% sodium bicarbonate, 0.2-2.0% surfactant and 0.1%-5% lubricant, characterized in that: the traditional Chinese medicine Muzu effervescent tablet also contains Total mass 1-10% zedoary oil, 3-10% Sophora flavescens, 5-30% sodium chloride and appropriate amount of binder
The raw materials of traditional Chinese medicine in the scheme described in the above-mentioned patent application are zedoary oil and flavescens, as can be seen from the description in the instruction manual, the raw material of flavescens is just used as medicine after being pulverized, so although it is made into an effervescent tablet, it can make the tablet It dissolves rapidly when it meets water, but the active ingredients in Sophora flavescens raw material powder still cannot be dissolved quickly and fully at the water temperature acceptable to the human body

Method used

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  • Footbath effervescent tablet for improving rheumatic arthritis
  • Footbath effervescent tablet for improving rheumatic arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] prescription:

[0049] Raw materials: cinnamon 318g, ginger 1206g, Achyranthes bidentata 594g, Gentiana 594g, Eupatorium 594g, Mori 594g, Duhuo 594g, Chishao 594g, Xu Changqing 594g, Fangji 318g;

[0050] Excipients: citric acid 600g (calculated as anhydrous matter), sodium bicarbonate 780g, polyethylene glycol 6000 120g.

[0051] Preparation method:

[0052] For the above ten flavors, crush cinnamon into fine powder and sieve; add water to decoct the other nine herbs such as old ginger twice, add 8 times the amount of water for the first time, and add 6 times the amount of water for the second time, 3 hours each time, Combine the two decoctions, filter, concentrate the filtrate to a thick paste with a relative density of 1.25-1.30 (measured at 60°C), add 7 / 10 cinnamon fine powder, mix well, dry at 80°C, crush into fine powder, and sieve. Citric acid and sodium bicarbonate were dried separately, pulverized into fine powder, sieved, and set aside. Divide the above ext...

Embodiment 2

[0054] prescription:

[0055] Raw materials: 180g cinnamon, 943g old ginger, 629g Achyranthes bidentata, 817g Gentiana chinensis, 1006g Zeilan, 817g mulberry branch, 629g Duhuo, 440g red peony root, 300g Xu Changqing, 239g Fangji;

[0056] Excipients: citric acid 300g (calculated as anhydrous matter), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, polyethylene glycol 4000 40g.

[0057] Preparation method:

[0058] For the above ten flavors, crush cinnamon into fine powder and sieve; add water to decoct the other nine herbs such as old ginger for two times, add 10 times the amount of water for the first time, add 10 times the amount of water for the second time, 1.5 hours each time, Combine the two decoctions, filter, concentrate the filtrate to a thick paste with a relative density of 1.25-1.30 (measured at 60°C), add 7 / 10 cinnamon fine powder, mix well, dry at 75°C, crush into fine powder, and sieve. Citric acid, fumaric ac...

Embodiment 3

[0060] prescription:

[0061] Raw materials: cinnamon 180g, ginger 943g, Achyranthes bidentata 300g, Gentiana 440g, Zeilan 629g, mulberry branch 817g, Duhuo 1006g, Chishao 817g, Xu Changqing 629g, Fangji 239g;

[0062] Excipients: citric acid 300g (calculated as anhydrous matter), adipic acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, polyethylene glycol 5000 30g, sodium lauryl sulfate 10g, manna Alcohol 100g, peppermint oil, rose oil (appropriate amount).

[0063] Preparation method:

[0064] For the above ten flavors, crush cinnamon into fine powder and sieve; add water to decoct the other nine medicinal materials such as old ginger for two times, add 7 times the amount of water for the first time, and add 7 times the amount of water for the second time, 2.5 hours each time, Combine the two decoctions, filter, concentrate the filtrate to a thick paste with a relative density of 1.25-1.30 (measured at 60°C), add 6 / 10 cinnamon fine p...

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Abstract

The invention relates to a traditional Chinese medicine compound preparation, in particular to a footbath effervescent tablet. The footbath effervescent tablet is mainly prepared from active ingredients, effervescent excipient, and adhesive. The compound preparation is characterized in that the active ingredients consist of 3wt%-10wt% of cinnamamun cassia powder, and water extracts of the following raw materials in percentage by weight: 15%-30% of old ginger, 5%-20% of achyranthes bidentata, 5%-20% of gentiana macrophylla, 5%-20% of lycopus lucidus, 5%-20% of ramulus mori, 5%-20% of Radix Angelicae Pubescentis, 5%-20% of Radix Paeoniae rubra, 5%-20% of paniculate swallowwort root, and 3%-10% of Fangji root. The invention has the functions of adjusting the function of viscera, expelling evil-wind and removing dampness, warming and activating meridian, promoting blood circulation and removing blood stasis, eliminating cold to stop pain, and improving rheumatic arthritis.

Description

field of invention [0001] The invention relates to medical preparations, in particular to a traditional Chinese medicine compound preparation. technical background [0002] Rheumatic diseases refer to a large group of diseases with different etiologies, but the common point is that they involve joints and surrounding soft tissues, including muscles, ligaments, synovial bursa, and fascia. Arthropathy is accompanied by swelling and movement disorder in addition to pain, and is a chronic course of alternating attacks and remissions. Because the patient's blood circulation is not smooth, the nutrients needed by the muscles or tissues cannot be transported through the blood circulation, resulting in the lack of nutrients in the muscles of the patients and accelerated aging and stiffness. In severe cases, the muscles and blood vessels of the patients will atrophy, and some patients may also appear Joint disability and organ failure. At present, the pathogenesis of rheumatism is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/46A61P19/02A61P29/00
Inventor 方永奇方惠新王淑英刘林
Owner GUANGDONG JIANDA LIGHTING ELECTRICAL APPLIANCE CO LTD
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