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Medicament for resisting influenza and preparation method and application thereof

An anti-influenza and pharmaceutical preparation technology, applied in the field of anti-influenza, can solve the problems of ineffectiveness and high toxicity of vaccines and targeted drugs, and achieve the effects of easy promotion, rational selection of prescriptions, low economic cost and resource cost

Inactive Publication Date: 2010-08-04
KMS MEDITECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the mutation rate of influenza A (H1N1) virus exceeds that of HIV, and the mutated influenza A (H1N1) virus may be more virulent, and the existing vaccines and targeted drugs may all fail

Method used

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  • Medicament for resisting influenza and preparation method and application thereof
  • Medicament for resisting influenza and preparation method and application thereof
  • Medicament for resisting influenza and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0030] The preparation method of embodiment 1-4:

[0031] 1) Weigh Houttuynia cordata according to the amount converted in parts by weight shown in the above table, properly pulverize, sieve, place in a volatile oil extraction device, add 10 times the amount of water, soak in warm for 0.5h, heat, steam distill, Distillate was collected after 4h. The distillate was extracted three times with ether, the extract was dried with anhydrous sodium sulfate for 24 hours, and then filtered. The filtrate was evaporated with a rotary evaporator to remove the ether, and the volatile oil was collected. The volatile oil appeared light yellow-green. The residue was decocted twice again, adding 5 times the amount of water each time, decocting for 1 hour, filtering, combining the filtrates for later use, and discarding the residue.

[0032] 2) Scutellaria baicalensis, Polygonum cuspidatum, Xinyi flower and licorice were weighed according to the amounts converted in parts by weight shown in the...

Embodiment 5

[0034] The preparation method of embodiment 5:

[0035] 1) Weigh Scutellaria baicalensis, Polygonum cuspidatum, Magnolia magnolia and Radix Glycyrrhizae according to the amounts converted in parts by weight shown in the above table. Appropriately pulverize, sieve, add 10 times the amount of water, decoct twice for 2 hours each time, filter the extract, and combine the filtrates, each ml is equivalent to 0.1 g of raw material medicine.

[0036] 3) Preparation process: add an appropriate amount of sucrose to the combined filtrate, and then divide into 10 ml bottles to obtain oral preparations.

experiment example

[0038] 1. Materials and methods

[0039] 1. Viruses

[0040] Influenza virus murine lung-adapted strain FM1 (type A H1N1 virus) was provided by the Institute of Virology, Chinese Academy of Preventive Medicine. Passage chicken embryos, test in BSL-3 (Biosafety Laboratory Level 3), subpackage, and store at -80°C.

[0041] 2. Experimental animals

[0042] 72 BALB / c mice weighing 20-22 g were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and were bred under clean-grade conditions in the animal room of our institute.

[0043] 3. Experimental drugs

[0044] The experimental medicines were the medicines of Examples 1, 2 and 5. The positive control drug was commercially available ribavirin (0.15 g once for adults, 3 times a day for 7 consecutive days) approved by SFDA (Sichuan Baili Pharmaceutical lot: 081017).

[0045] 4. Experimental method

[0046] Mice are divided into 6 groups at random and are blank control group, virus infection group, po...

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Abstract

The invention discloses a Chinese medicinal composition for resisting influenza in particular H1N1 influenza A, and a preparation method thereof. The Chinese medicinal composition for resisting the influenza is characterized by being prepared from the following raw materials in part by weight: 10 to 20 parts of baical skullcap root, 20 to 60 parts of giant knotweed rhizome, 5 to 10 parts of flos magnoliae liliflorae, and 5 to 10 parts of licorice. In order to further improve the curative effect, the Chinese medicinal medicament also comprises 15 to 30 parts of heartleaf houttuynia herb in part by weight. The medicament is prepared according to the following formula principles of: reasonable formula selection, clinical effectiveness, abundant resources, economical efficiency and practicability, and convenient popularization. Thus, the medicament reduces the types of used Chinese medicinal materials as much as possible, and under the condition that the influenza happens, particularly the H1N1 influenza A is pandemic, the Chinese medicinal composition can be popularized on a national scale to effectively prevent and control the spread of the influenza with the minimum economic cost and resource cost.

Description

technical field [0001] The invention relates to an anti-influenza, especially a traditional Chinese medicine composition and medicine for anti-influenza A (H1N1), a preparation method and application thereof. Background technique [0002] Influenza A (H1N1) virus is a subtype of influenza virus and one of the most common influenza (flu) in humans. Some strains of H1N1 virus can cause seasonal pandemics. From the end of March to mid-April 2009, the H1N1 influenza (formerly known as H1N1 swine flu) outbreaks broke out in many countries in the Americas, and then spread globally. According to the report of the World Health Organization, as of August 23, 2009, there have been 209,438 cases and at least 2,185 deaths worldwide. [0003] According to reports, by the end of 2009, the production capacity of my country's influenza A (H1N1) vaccine can only cover about 5% of the country's population. The anti-influenza specific drugs (such as oseltamivir) that have been reported are a...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K36/78A61P31/16A61P11/00
CPCA61K36/575A61K36/484A61K36/61A61K36/704A61K36/185A61K9/0095A61P11/00A61P31/12A61P31/16
Inventor 徐峻刘延淮于群唐国顺顾琼刘海波孙志一古练权
Owner KMS MEDITECH
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