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Application of calcium disodium edentate and corticosteroid compound preparation in preparing medicine capable of inhibiting connective tissue growth factors and monoamine oxidase

A technology of edetate calcium sodium and compound preparations, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as poor therapeutic effects

Active Publication Date: 2010-08-04
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned CTGF and MAO are all enzymes or factors that play an important role in pulmonary fibrosis. The therapeutic drugs in the prior art have poor therapeutic effect because they cannot target the pathogenic factors of pulmonary fibrosis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 prepares injection

[0024] Dexamethasone Sodium Phosphate 1g

[0025] Disodium hydrogen phosphate 1g Sodium dihydrogen phosphate 0.05g

[0026] Edetate Calcium Sodium 200g

[0027] Dissolve the prescribed amount of dexamethasone sodium phosphate in an appropriate amount of water for injection, add the prescribed amount of phosphate, stir to dissolve, and add calcium sodium edetate. Add water for injection to 1000ml, dissolve, filter, subpackage to obtain an injection containing 1 mg of dexamethasone sodium phosphate and 0.2 g of edetate calcium sodium per ml.

Embodiment 2

[0029] Dexamethasone Sodium Phosphate 0.5g

[0030] Disodium hydrogen phosphate 1g Sodium dihydrogen phosphate 0.05g

[0031] Edetate Calcium Sodium 200g

[0032] Dissolve the prescription amount of dexamethasone sodium phosphate raw material in an appropriate amount of water for injection, add the prescription amount of phosphate, add water for injection to 1000ml, filter, subpackage, and sterilize to obtain an injection containing 0.5 dexamethasone sodium phosphate per ml. mg, edetate calcium sodium 0.2g

Embodiment 3

[0034] Dexamethasone Sodium Phosphate 0.1g

[0035] Disodium hydrogen phosphate 1g

[0036] Sodium dihydrogen phosphate 0.1g Sodium edetate calcium 200g

[0037] Dissolve the prescribed amount of dexamethasone sodium phosphate raw material in an appropriate amount of water for injection, add the prescribed amount of phosphate, stir to dissolve, add calcium sodium edetate, add water for injection to 1000ml, dissolve, filter, pack, and sterilize The obtained injection contains 0.1 mg of dexamethasone sodium phosphate and 0.2 g of edetate calcium sodium per ml.

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PUM

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Abstract

The invention relates to the application of a calcium disodium edentate and corticosteroid compound preparation in preparing medicine capable of inhibiting connective tissue growth factors and monoamine oxidase, and provides a compound preparation prepared from calcium disodium edentate and corticosteroid, which comprises the calcium disodium edentate which serves as the active component, the corticosteroid and one or more medicinal auxiliary ingredients; and the compound preparation contains the calcium disodium edentate in the weight percentage of 2 to 20 percent, glucocorticoid in the weight percentage of 0.01 to 0.1 percent, and the auxiliary ingredients which can be used for injection.

Description

technical field [0001] The invention relates to the application of a compound preparation of calcium sodium edetate and corticosteroids in the preparation of medicines for treating human diseases, and also relates to a compound injection of calcium sodium edetate and corticosteroids. Background technique: [0002] Edetate Calcium Sodium (Ca-Na 2 EDTA) is a kind of metal ion chelating agent, can be used for and can be used for with multiple divalent, trivalent metal chelation, forms stable possible metal complexes, and existing edetate calcium sodium preparation is mainly injection (1g , 5ml) and tablet (0.5g / tablet), mainly used in the clinical treatment of inorganic lead poisoning, for copper, zinc, iron, manganese, cadmium, vanadium, cobalt and certain radioactive elements such as thorium, uranium, radium, Plutonium, etc. also have a certain excretion-promoting effect, but they can cause kidney damage and cause severe edema, degeneration and other side effects in the prox...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/198A61P11/00A61P11/06
Inventor 李静王虹杨国存程振国于润芳林劼张冬兰吴媛媛肖敏霞张岚刘凯
Owner TIANJIN JINYAO GRP
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