Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of micron-sized polymethylmethacrylate microsphere

A polymethyl methacrylate, micron-scale technology, applied in the field of biomedical materials, to achieve the effect of mild implementation conditions and simple operation process

Active Publication Date: 2010-07-28
SUMMIT GD BIOTECH
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no precedent for preparing PMMA microspheres with a particle size range of 10-100 μm by solvent evaporation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of micron-sized polymethylmethacrylate microsphere
  • Preparation method of micron-sized polymethylmethacrylate microsphere
  • Preparation method of micron-sized polymethylmethacrylate microsphere

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] A preparation method of micron polymethyl methacrylate microspheres, comprising the following steps:

[0018] (1) Polymethyl methacrylate (PMMA) is dissolved in organic solvent, and the mass fraction range of polymethyl methacrylate solution is 0.5~5.0%; Organic solvent can be dichloromethane, dichloroethane, chloroform , tetrahydrofuran, toluene, acetone or both; the preferred range of the mass fraction of the polymethyl methacrylate solution is 0.7-3.0%, and the more preferred range is 0.9-1.5%.

[0019] (2) Polyvinyl alcohol is dissolved in deionized water to prepare a polyvinyl alcohol solution with a mass percentage (weight) concentration of 0.5 to 2.5%; polymethyl methacrylate solution (PMMA solution) is added dropwise under magnetic stirring Add polyvinyl alcohol solution, the volume ratio of water phase to organic phase is 1-10:1; wherein the water phase is polyvinyl alcohol solution, and the organic phase is polymethyl methacrylate solution; after adding polyme...

Embodiment 1

[0023] Weigh 1 g of polymethyl methacrylate (PMMA) with a relative molecular mass of 410,000, dissolve it in 100 mL of chloroform, and dissolve it completely. Measure 20 mL of 1% polyvinyl alcohol (PVA) aqueous solution, put it into a 500 mL Erlenmeyer flask, and stir with a magnetic stirrer at a stirring speed of 1400 r / min. Add 10 mL of the completely dissolved PMMA solution dropwise into the PVA aqueous dispersion medium. Cover the mixture after the addition, and keep stirring evenly at room temperature for about 120 minutes. The evenly distributed and stable emulsion was ultrasonically treated for 10 minutes (ultrasonic power 150W), then the lid was opened, and stirring was continued for 6-8 hours at 40-50°C. After the solvent evaporated, filter with a glass sand funnel to collect the microspheres. At room temperature, the PMMA microspheres were dispersed in distilled water, and then centrifuged with a high-speed refrigerated centrifuge, and the operation was repeated th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of a monodisperse micron-sized polymethylmethacrylate microsphere. The microsphere is prepared through emulsion dispersion and solvent evaporation with polymethylmethacrylate as a raw material and polyvinyl alcohol solution as a dispersion medium. The preparation method comprises the following steps: preparation of uniform and stable emulsion by adding PMMA solution into aqueous solution of polyvinyl alcohol at a certain flow rate under the high-speed stirring condition, ultrasonic dispersion, solvent evaporation, filtration, washing, vacuum drying and the like, so as to prepare a microsphere with a smooth surface, regular particles and no adhesion. The particle size of the microsphere is 10-100 Mum, and both the particle size and the particle size distribution can be controlled. Compared with the prior art, the invention has the advantages of simple operating process and mild implementation conditions, and provides a simple and feasible novel method for preparation of the micron-sized polymethylmethacrylate microsphere. The prepared micron-sized polymethylmethacrylate microsphere can be applied in the field of biomedical materials such as drug carriers, bone repair materials, plastic materials and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a preparation method of micron-sized polymethyl methacrylate microspheres. Background technique [0002] Polymethyl methacrylate (PMMA) is the most important and most commonly used material in acrylates. It has excellent performance and a wide range of uses. It has become one of the plastic products widely used in various sectors of the national economy. Polished PMMA is widely used in the production of medical utensils, transparent covers of medical equipment (such as incubators, operation boxes, etc.), observation mirrors, surgical tools, etc. Because PMMA has good compatibility with human tissue, is non-toxic to human body, has good light transmittance, stable chemical properties, and is easy to process into the desired shape, so PMMA can be used in medicine to make artificial corneas, orthopedic bonding and fixed joint prostheses. Body, bone cement, dentures, dentures, mo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J3/12C08L33/12
Inventor 王秀梅金玉顺夏雪崔福斋
Owner SUMMIT GD BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com