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Levamlodipine compound drug composition

A technology of levamlodipine and a composition, applied in the field of pharmacy, can solve problems such as electrolyte disturbance and hypokalemia, and achieve the effects of reducing edema, lowering blood pressure, and reducing side effects of edema

Inactive Publication Date: 2010-07-21
SHIHUIDA PHARMA GRP (JILIN) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chlorthalidone has the advantage of quicker antihypertensive effect, but long-term use alone can cause water and electrolyte disorders, resulting in hypokalemia; inhibit insulin release and cause hyperglycemia; interfere with renal tubular excretion of uric acid and cause hyperuricemia

Method used

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  • Levamlodipine compound drug composition
  • Levamlodipine compound drug composition
  • Levamlodipine compound drug composition

Examples

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Embodiment 1～6

[0036] Table 4 is the proportioning table for making 1000 levamlodipine and chlorthalidone compound tablets.

[0037] The formula of table 4 levamlodipine and chlorthalidone compound tablet

[0038]

[0039]Table 4 (continued) the formula of levamlodipine and chlorthalidone compound tablet

[0040]

[0041]

[0042] Preparation process: put levamlodipine, chlorthalidone, microcrystalline cellulose, pregelatinized starch, lactose, and sodium hydroxymethyl starch into a mortar, grind and mix evenly, pass through a 20-mesh sieve, and add an appropriate amount of 95% ethanol to prepare It is made into soft material, granulated through a 20-mesh sieve, ventilated and dried at 40°C, the dry granules are granulated with a 16-mesh sieve, added magnesium stearate, mixed evenly, and pressed into tablets.

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Abstract

The invention discloses a levamlodipine compound drug composition, which comprises levamlodipine or a pharmaceutically acceptable salt thereof and chlorthalidone. The combined drug of the levamlodipine and the chlorthalidone of the invention can be used for treating hypertension, the levamlodipine and the chlorthalidone have good synergic function for blood pressure reduction, and the invention can eliminate the side effect of edema caused by sodium water retention when the levamlodipine is separately used as the drug. In addition, the levamlodipine can enhance the insulin sensitivity of the body and resist the side effect of blood sugar rise caused by chlorthalidone. Moreover, the drug combination of the levamlodipine and the chlorthalidone can overcome the defect that the the levamlodipine is slow to become effective in blood pressure reduction.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to a compound pharmaceutical composition of levamlodipine. Background technique [0002] Hypertension is a clinical syndrome characterized by elevated systemic arterial systolic blood pressure (SBP) and / or diastolic blood pressure (DBP), and is currently one of the most common cardiovascular diseases. According to the latest statistics, the prevalence of hypertension in my country has risen to 11.68%, especially the damage to target organs such as the heart, brain, and kidney secondary to hypertension, which seriously affects the life expectancy and quality of life of patients. [0003] Amlodipine is a third-generation dihydropyridine calcium channel blocker, a long-acting dihydropyridine antihypertensive drug, and its chemical name is 3-ethyl-5-methyl-2-(2-aminoethoxymethyl base)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridine dicarboxylate. The compound has two isomers, left-handed ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/4035A61P9/12
CPCA61K9/4866A61K31/4035A61K9/2059A61K31/4422A61P9/12A61K2300/00
Inventor 杨彦玲薛传校张喜田许威张严
Owner SHIHUIDA PHARMA GRP (JILIN) LTD
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