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Application of resveratrol to treating kidney disease

A technology for resveratrol and kidney disease, applied in the direction of urinary system diseases, active ingredients of hydroxyl compounds, drug combinations, etc., can solve problems such as low immune function of the body, affecting disease treatment, kidney toxicity and side effects, and achieves small adverse reactions, Good treatment of kidney disease, good therapeutic effect

Inactive Publication Date: 2010-07-21
张爱华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment of primary nephrotic syndrome is mainly based on adrenal glucocorticoids, and the treatment cycle is long. Long-term use of this type of drugs will cause a decrease in the immune function of the body, thereby affecting the treatment of the disease, and long-term use of glucocorticoids will cause Minimal change nephropathy is the most common pathological type of nephrotic syndrome in children, and its pathological changes are mainly manifested in the glomerular epithelial cell foot processes under the electron microscope. It is characterized by fusion; at the same time, glomerulonephritis is also the main disease that endangers human life and health in kidney diseases, and the number of deaths due to glomerulonephritis is increasing year by year. Long-term use of chemical drugs can produce a variety of adverse reactions, and some drugs can cause serious toxic side effects to the kidneys through renal excretion

Method used

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  • Application of resveratrol to treating kidney disease
  • Application of resveratrol to treating kidney disease
  • Application of resveratrol to treating kidney disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Pharmacological effects of resveratrol on primary nephrotic syndrome.

[0019] 1. Experimental materials

[0020] Aminonucleoside puromycin and resveratrol were purchased from Sigma, USA; SuperScript III RNase H-Reverse Transcriptase Kit was purchased from Invitrogen, USA; goat anti-nephrin, podocin antibody, horseradish peroxidase-labeled anti-goat and mouse Secondary antibodies were purchased from Santa Cruz, USA.

[0021] 2. Experimental method

[0022] 1. Animal model preparation and experimental grouping

[0023] 40 male SD rats, weighing 80-100 g, were randomly divided into normal control group, model group, low-dose resveratrol group, high-dose resveratrol group and resveratrol control group, 8 in each group. Only. Wherein the model group, the resveratrol low-dose group and the resveratrol high-dose group were given a one-time intraperitoneal injection of aminonucleoside puromycin (PAN) at a dose of 150 mg / kg to prepare an animal model of nephrotic...

Embodiment 2

[0047] Example 2 Pharmacological effects of resveratrol on mesangial proliferative glomerulonephritis.

[0048] 1. Experimental materials

[0049] 40 healthy male SD rats, 4 weeks old, weighing about 160g, were purchased from the Experimental Animal Center of Jiangsu Province; resveratrol, complete Freund's adjuvant, FITC-labeled goat anti-rabbit IgG and Schiff reagent were purchased from Sigma, USA , proliferating cell nuclear antigen (PCNA) and monocyte chemoattractant-1 (MCP-1) monoclonal antibodies were purchased from Sant Cruz, USA, horseradish peroxidase-labeled goat anti-rabbit IgG, normal goat serum blocking solution, DAB chromogen was purchased from Beijing Zhongshan Biotechnology Company.

[0050] 2. Experimental method

[0051] 1. Preparation of anti-rat thymocyte antiserum (ATS):

[0052] Select 4-week-old SD rats, take their thymus and prepare a single thymocyte suspension with a certain concentration, mix it with complete Freund's adjuvant in equal volume, and...

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Abstract

The invention discloses application of resveratrol to treating kidney disease. Animal experiment research shows that the resveratrol has better function of protecting the kidney, remarkable inhibition function of pathological symptoms of proteinuria, sertoli cell injury, mesangial cell proliferation, extracellular matrix accumulation and the like, and better prevention and treatment functions on primary nephrotic syndrome and mesangial proliferative glomerulonephritis. The resveratrol has easy obtaining of raw materials, strong pathological activity and low adverse effects, and is hopeful to be a new generation medicine for treating the kidney disease.

Description

technical field [0001] The invention relates to an anthraquinone terpene compound, in particular to the application of resveratrol in treating kidney disease. Background technique [0002] Kidney disease is a serious threat to human life and health. Tens of millions of patients die of kidney disease every year. Primary nephrotic syndrome is a common urinary system disease in pediatrics. The main clinical manifestations are proteinuria, hypoproteinemia, high Lipidemia and different degrees of edema, the number of children who die each year due to primary nephrotic syndrome is on the rise. It is reported abroad that the incidence rate of people under the age of 16 is about 15.7 / 100,000. Children hospitalized in hospitals in some provinces and cities in my country According to statistics, nephrotic syndrome accounts for about 21% to 31% of children with urological diseases. If active and effective treatment is not adopted for nephrotic syndrome, children often die of various comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P13/12
Inventor 张爱华黄松明
Owner 张爱华
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