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Preparation method of surface imprinted material for matrine substance separation and purification

A technology of surface imprinting and substance separation, applied in the field of preparation of ionic surface imprinting materials, can solve the problems of low efficiency of surface imprinting materials, and achieve the effects of low cost, strong identification selectivity and good selectivity

Inactive Publication Date: 2010-07-14
ZHONGBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of low efficiency of surface-imprinted materials for separating matrine-like substances, the present invention provides a method for preparing surface-imprinted materials for the separation and purification of matrine-like substances

Method used

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  • Preparation method of surface imprinted material for matrine substance separation and purification
  • Preparation method of surface imprinted material for matrine substance separation and purification
  • Preparation method of surface imprinted material for matrine substance separation and purification

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Add 30g of silica gel particles to 150mL of 9% hydrochloric acid aqueous solution, stir and activate at reflux temperature, so that the surface of the silica gel particles has more hydroxyl groups, after 8 hours of activation, filter, fully wash the filter cake with distilled water, and finally put it in a vacuum oven Dry in a medium vacuum for 26 hours to obtain activated silica gel particles. Add 10g of activated silica gel particles into a four-necked flask, then add 360mL of ethanol and water mixed solvent with a volume ratio of 1:1 and stir, then add 10mL of γ-(methacryloyloxy)propyltrimethoxysilane KH-570, react at 48°C for 27h, after the reaction, wash the product with ethanol in a Soxhlet extractor to remove unreacted γ-(methacryloyloxy)propyltrimethoxysilane KH- 570, and finally vacuum-dried in a vacuum oven for 24 hours to obtain silica gel particles MPS-SiO modified by γ-(methacryloyloxy)propyltrimethoxysilane KH-570 2 . Add 200mL of water and 5g of silica ...

Embodiment 2

[0039] Add 28g of silica gel particles into 140mL of 5% hydrochloric acid aqueous solution, stir and activate at reflux temperature, so that the surface of silica gel particles has more hydroxyl groups, after 10 hours of activation, filter, fully wash the filter cake with distilled water, and finally put it in a vacuum oven Dry in a medium vacuum for 28 hours to obtain activated silica gel particles. Add 9g of activated silica gel into a four-neck flask, then add 330mL of ethanol and water mixed solvent (volume ratio: 1:1) and stir, then add 8mL of trimethoxyallylsilane, and react at 47°C for 24h , after the reaction, the product was washed with ethanol in a Soxhlet extractor to remove unreacted trimethoxyallylsilane in the system, and finally vacuum-dried in a vacuum oven for 30h to obtain modified silica gel particles MPS-SiO 2 . Add 230mL water, 4g modified silica gel particle MPS-SiO 2 and 10g methacrylic acid, with N 2 Exhaust the air for 30min, and in N 2 Stir under ...

Embodiment 3

[0041] Add 25g of silica gel particles into 145mL of 8% hydrochloric acid aqueous solution, stir and activate at reflux temperature, so that the surface of silica gel particles has more hydroxyl groups, after 9 hours of activation, filter, fully wash the filter cake with distilled water, and finally put it in a vacuum oven Dry in medium vacuum for 30 hours to obtain activated silica gel particles. Add 8g of activated silica gel to a four-neck flask, then add 300mL of ethanol and water mixed solvent (volume ratio: 1:1) and stir, then add 9mL of trimethoxyallylsilane, and react at 45°C for 26h , after the reaction, the product was washed with ethanol in a Soxhlet extractor to remove unreacted trimethoxyallylsilane in the system, and finally vacuum-dried in a vacuum oven for 28 hours to obtain modified silica gel particles MPS-SiO 2 . Add 250mL water, 3g modified silica gel particles MPS-SiO 2 and 12g methacrylic acid, with N 2 Exhaust the air for 30min, and in N 2 Stir under...

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Abstract

The invention discloses a preparation method of surface imprinted material for matrine substance separation and purification, which aims to solve the problem of low efficiency of the surface imprinted material for separating matrine, and comprises the following steps that: silica particles are activated; a silica particle surface chemical bond is connected with silane coupling agent containing double bonds; the surface of the silica particles is chemically grafted with polymethylmethacrylate; and silica particle surface molecular imprinted polymer is prepared. The invention prepares the surface imprinted material which has high molecular association speed, strong identification selectivity and high association capacity to the matrine substance with the silica particles as a carrier, the methacrylate as functional macromolecular material to be grafted with the particles or the surface of the particles and the double-bond silane coupling agent as cross linker; and the surface imprinted material prepared through the method is applicable to the requirements of industrial production, has high material utilization rate, low cost, good selectivity to matrine substance molecules, very strong identification and association properties, and very good desorption performance.

Description

technical field [0001] The invention relates to a preparation method of an ion surface imprinted material, in particular to a preparation method of a surface imprinted material used for the separation and purification of matrine substances. Background technique [0002] Matrine substances are mainly derived from leguminous plants Sophora flavescens and Sophora flavescens, and are a class of alkaloids with various pharmacological effects and functions such as antitumor, antibacterial and antiviral. Because matrine has great development value as an anticancer drug, the research and development of matrine at home and abroad has attracted much attention in recent years. Matrine is extracted and purified from the leaching solution of Sophora flavescens and Sophora flavescens. Since the leaching solution contains at least 21 kinds of alkaloids and various flavonoids, it is a very complicated extraction project of biologically active components. [0003] Molecularly imprinted mate...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08J3/24C08F292/00C08F120/06C09C1/28C09C3/12B01J20/30B01J20/26
Inventor 高保娇安富强杜瑞奎喻华兵王蕊欣
Owner ZHONGBEI UNIV
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