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Artificial bone with porous laminated structure and passages and preparation method thereof

A laminated structure, artificial bone technology, applied in bone implants, medical science, prosthesis, etc., can solve unfavorable bone cell adhesion, proliferation, differentiation, growth of new bone tissue, lack of bone cell pores and body fluid channels , can not be used for bone defect repair and other problems, to achieve good biocompatibility, conducive to ingrowth and vascularization, and to speed up the effect of repair and reconstruction

Inactive Publication Date: 2013-06-19
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently used massive calcium phosphate-based bioceramic artificial bones mainly include overall compact and porous types. The dense artificial bone has high strength and can be used for the repair of bone defects in load-bearing parts, but it lacks pores and bone cells to grow into. Body fluid channel, which is not conducive to the adhesion, proliferation, differentiation, growth and formation of new bone tissue of bone cells
Porous artificial bone has a pore structure formed by bone cell ingrowth and vascularization, which is conducive to the repair and reconstruction of bone tissue, but its strength is low, and it cannot be used for the repair of bone defects in load-bearing parts, and its application range is limited.

Method used

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  • Artificial bone with porous laminated structure and passages and preparation method thereof

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Embodiment 1

[0035] The artificial bone in this embodiment is formed by alternating dense layers and porous layers of calcium phosphate-based bioceramic materials, and channels for transporting cells and body fluids are provided in a direction at a certain angle to the layers. Among them, the thickness of the dense layer of the artificial bone is 0.1mm, the thickness of the porous layer is 0.3mm, the diameter of the pores is 0.1-0.3mm, the porosity is 20%-60%, the diameter of the channel is 0.5-0.6mm, and the gap between the channel and the laminate is The angle is 10°, and the channel spacing is 1-2mm.

[0036] The preparation method of the present embodiment comprises the following steps:

[0037] (1) taking 100wt% hydroxyapatite (HA) as raw material powder;

[0038] (2) The powder in (1) is mixed with deionized water according to the volume percentage of solid phase content of 30vol%, and the content of the gelling agent sodium alginate relative to the weight percentage of deionized wa...

Embodiment 2

[0046] The artificial bone in this embodiment is formed by alternating dense layers and porous layers of calcium phosphate-based bioceramic materials, and channels for transporting cells and body fluids are provided in a direction at a certain angle to the layers. Among them, the thickness of the dense layer of the artificial bone is 0.5mm, the thickness of the porous layer is 0.6mm, the diameter of the pores is 0.2-0.4mm, the porosity is 30%-70%, the diameter of the channel is 1mm, and the angle between the channel and the stack is The spacing between the 30° channels is 2-3mm.

[0047] The preparation method of the present embodiment comprises the following steps:

[0048] (1) beta-tricalcium phosphate with a content of 100wt% as raw material powder;

[0049] (2) The powder in (1) is mixed with deionized water according to the volume percentage of solid phase content of 40vol%, and the content of the gelling agent sodium alginate relative to the weight percentage of deioniz...

Embodiment 3

[0057] The artificial bone in this embodiment is formed by alternating dense layers and porous layers of calcium phosphate-based bioceramic materials, and channels for transporting cells and body fluids are provided in a direction at a certain angle to the layers. Among them, the thickness of the dense layer of the artificial bone is 1.6mm, the thickness of the porous layer is 1.6mm, the pore diameter is 0.3-0.5mm, the porosity is 30%-60%, the channel diameter is 1.2mm, the angle between the channel and the lamination The spacing between channels for 60° is 1-3mm.

[0058] The preparation method of the present embodiment comprises the following steps:

[0059] (1) mixing 60wt% hydroxyapatite (HA) and 40wt% beta-tricalcium phosphate (beta-TCP) powder;

[0060] (2) The mixed powder in (1) is mixed with deionized water according to the volume percentage of solid phase content of 50vol%, and the content of the gelling agent sodium alginate relative to the weight percentage of dei...

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Abstract

The invention relates to an artificial bone with a porous laminated structure and passages, which belongs to the technical field of biomedical materials. The artificial bone is alternately laminated and formed by compact layers and porous layers which are made of calcium phosphate base biological ceramic materials, and in addition, passages for conveying cells and body fluid are arranged in the direction which forms a set angle with the laminated layers. The preparation method comprises the following step: mixing powder such as hydroxylapatite, beta-tricalcium phosphate and the like through using deionized water as medium to be prepared into pulp. A three-dimensional gel laminated forming system is adopted for preparing ceramic blanks formed by the compact layers, the porous layers and the passages, and then the ceramic blanks are sintered at a high temperature for preparing the artificial bone. The invention has the characteristics that the artificial bone has high mechanical strength, has the porous structure with the effects of osteoplast adhesion, propagation, growth and vascularization, can be used as the artificial bone, can also be used as a bone tissue engineering support frame, and has wide application prospects in clinics in the orthopedics department.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to an artificial bone, in particular to an artificial bone with a porous laminated structure and a channel, Background technique [0002] The repair of bone defects due to trauma, infection, tumor resection and osteomyelitis has always been one of the difficult problems in the field of orthopedics. At present, the main method of bone repair is to perform bone grafting operation, which is to transplant autologous bone, allogeneic bone or artificial bone to the part of the patient's body where the bone is defective or needs to be strengthened and fixed. [0003] Autologous bone grafting has high osteoinductivity and no immune rejection, but it will increase surgical trauma, and the source of bone is also very limited. Allogeneic bone transplantation not only has the problem of source, but also produces immune rejection and surgical complications. During the transplantati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/12A61L27/56A61F2/28
Inventor 董利民王晨昝青峰李兆新田杰谟
Owner TSINGHUA UNIV
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