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Antibacterial artificial tooth root with bioactivity and preparation method thereof

An artificial tooth root, bioactive technology, applied in the direction of dental preparations, dentistry, dental prosthesis, etc., to achieve the effect of high bonding strength, good bioactivity, and less drug resistance

Inactive Publication Date: 2010-07-07
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Technical problem: The purpose of this invention is to address the above-mentioned shortcomings of artificial tooth root materials, and propose an artificial tooth root that has a slow-release function of trace element silver and can significantly improve the ability of the artificial tooth root surface to induce osteogenesis at the initial stage of implantation and its preparation method

Method used

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  • Antibacterial artificial tooth root with bioactivity and preparation method thereof
  • Antibacterial artificial tooth root with bioactivity and preparation method thereof
  • Antibacterial artificial tooth root with bioactivity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) First choose pure titanium to process the artificial tooth root;

[0026] (2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is polished and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. After 6 hours, a sodium titanate bioactive coating with a microporous structure was obtained on the surface of the artificial tooth root, and its SEM photos and XRD spectra are shown in figure 1 and figure 2 .

[0027] (3) Silver doping treatment by immersion method: immerse the surface hydrothermally treated artificial tooth root at a concentration of 5×10 -2 mol / L AgNO 3 In solution, AgNO with an operating temperature of 60°C 3 The solution was kept constant using a water bath method. Stir with a magnetic stirrer, take ou...

Embodiment 2

[0031] (1) First choose Ti6Al4V alloy to process the artificial tooth root;

[0032] (2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is polished and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours, and a sodium titanate bioactive coating with a microporous structure is obtained on the surface of the artificial tooth root.

[0033] (3) Silver-doped treatment by immersion method: immerse the surface hydrothermally treated artificial tooth root at a concentration of 2×10-1 mol / L AgNO 3 In solution, AgNO with an operating temperature of 60°C 3 The solution was kept constant using a water bath method. Stir with a magnetic stirrer, take out after soaking for 2 to 12 hours, ultrasonically clean with distille...

Embodiment 3

[0037] (1) First choose pure titanium to process the artificial tooth root;

[0038] (2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 150 degrees Celsius. After 72 hours, a sodium titanate bioactive coating with a microporous structure was obtained on the surface of the artificial tooth root.

[0039] (3) Silver doping treatment by immersion method: immerse the surface hydrothermally treated artificial tooth root at a concentration of 5×10 -2 mol / L AgNO 3 In solution, AgNO with an operating temperature of 60°C 3 The solution was kept constant using a water bath method. Stir with a magnetic stirrer, take out after soaking for 2 to 12 hours, ultrasonically clean with distilled water...

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Abstract

The present invention relates to an antibacterial artificial tooth root with bioactivity and a preparation method thereof. The antibacterial artificial tooth root consists of pure titanium-made or titanium alloy-made artificial tooth root base and a microcellular sodium titanate bioactive layer loaded with microelement of silver and bone morphogenetic protein (BMP). The sodium titanate bioactive layer with microcellular is combined with the surface of metal base, and is formed by alternately piling the microcellular structures of sodium titanate which is prepared by the hydrothermal reaction of titanium-made or titanium alloy-made base surface and sodium hydroxide solution. The silver takes cation exchange reaction with sodium to be doped in the layer and the BMP is combined in the microcellular structures by centrifugal force and capillary action. The preparation method is as follows: processing an artificial tooth root made of pure titanium or titanium alloy firstly, preparing a sodium titanate bioactive layer with microcellular structure on the surface of artificial tooth root through the technique of hydrothermal synthesis in alkali solution, then doping silver in the microcellular sodium titanate layer by ion exchange reaction in solution, and finally loading with the BMP in the microcellular sodium titanate layer adoped with silver through the technique of centrifugal load.

Description

technical field [0001] The invention relates to an antibacterial biologically active artificial tooth root and a preparation method thereof, in particular to a process base made of pure titanium or titanium alloy, and a microporous sodium titanate biologically active coating obtained by using lye hydrothermal synthesis technology, which is impregnated by solution The invention relates to an artificial tooth root loaded with bone morphogenetic protein loaded with ion exchange and silver, and a preparation method thereof, belonging to the technical field of artificial tooth root materials. Background technique [0002] Dental implants are internationally recognized as the first choice for restoration of missing teeth. They are similar to real teeth in terms of function, shape, and use effects, and can be called "artificial teeth." Dental implants are composed of artificial tooth roots and porcelain crowns. Pure titanium and its alloys are widely used in the manufacture of arti...

Claims

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Application Information

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IPC IPC(8): A61K6/04A61K6/02
Inventor 储成林郭超
Owner 江苏广达医材集团有限公司
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