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Method for preparing photoresponse hydrogel containing azo monomer by utilizing light sources with different wavelengths

A light-responsive, hydrogel technology, applied in the field of light-responsive hydrogels, can solve problems such as the adverse effects of restricted thermal diffusion and restricted hydrogen ion diffusion, and achieve mild conditions and simple steps.

Inactive Publication Date: 2011-06-15
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most widely used thermosensitive hydrogels and pH-sensitive hydrogels have their own disadvantages: thermosensitive hydrogels are limited by thermal diffusion and adverse effects of temperature on target molecules, pH-sensitive hydrogels are limited Diffusion of hydrogen ions

Method used

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  • Method for preparing photoresponse hydrogel containing azo monomer by utilizing light sources with different wavelengths
  • Method for preparing photoresponse hydrogel containing azo monomer by utilizing light sources with different wavelengths
  • Method for preparing photoresponse hydrogel containing azo monomer by utilizing light sources with different wavelengths

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Preparation of azo monomer as 4-sulfonic acid-4'acryloyloxyazobenzene hydrogel

[0021] (1) Sonicate four mixed solutions of HEA (1.5g), PEGDA-600 (0.15g), N, N methylenebisacrylamide (0.15g) and TPO (0.075g) with the same content for 10 minutes, and add 4-Sulphono-4'acryloyloxyazobenzene (0.015g, 0.03g, 0.045g, 0.06g) and water (3g). Irradiate (2 minutes, 5 minutes, 10 minutes, 30 minutes) respectively with ultraviolet lamp (50mw). The prepared colloid was washed with water for 5 times, and placed in a vacuum oven at 40° C. for 24 hours.

[0022] (2) Four parts of the same content of HEA (1.5g), PEGDA-600 (0.15g), N, N methylenebisacrylamide (0.15g), camphorquinone (CQ) and p-N, N-di The mixed solution of ethyl methylaminobenzoate (EDMAB) (0.075g) was ultrasonicated for 10 minutes, and 4-sulfonic acid-4'acryloyloxyazobenzene (0.015g, 0.03g, 0.045g, 0.06g ) and water (3g). Irradiate (5 minutes, 10 minutes, 30 minutes, 60 minutes) respectively with a visib...

Embodiment 2

[0025] Example 2: Preparation of azo monomer as 4-sulfonic acid-4'methacryloyloxyazobenzene hydrogel

[0026] (1) Sonicate four mixed solutions of HEMA (1.5g), PEGDA-400 (0.075g), N, N methylenebisacrylamide (0.075g) and TPO (0.0075g) with the same content for 10 minutes, and add 4-Sulphono-4'acryloyloxyazobenzene (0.015g, 0.03g, 0.045g, 0.06g) and water (4.5g). Use ultraviolet light (80mw) to irradiate (2 minutes, 5 minutes, 10 minutes, 30 minutes) respectively. The prepared colloid was washed with water for 5 times, and placed in a vacuum oven at 40° C. for 24 hours.

[0027] (2) Four parts of the same content of HEA (1.5g), PEGDA-400 (0.075g), N, N methylenebisacrylamide (0.075g), camphorquinone (CQ) and p-N, N-di The mixed solution of ethyl methylaminobenzoate (EDMAB) (0.0075g) was sonicated for 10 minutes, and 4-sulfonic acid-4'methacryloyloxyazobenzene (0.015g, 0.03g, 0.045g, 0.06g) and water (4.5g). Irradiate (5 minutes, 10 minutes, 30 minutes, 60 minutes) respectiv...

Embodiment 3

[0030] Example 3: Preparation of azo monomer as 4-carboxy-4'-acryloyloxyazobenzene hydrogel

[0031] (1) Sonicate five mixed solutions of the same content of HEA (1.5g), PEGDA-200 (0.225g), N, N methylenebisacrylamide (0.225g), TPO (0.03g) for 10 minutes, add 2-cyano-4-sulfo-2'-carboxy-4'-acryloxyazobenzene (0.015g, 0.03g, 0.045g, 0.06g, 0.075g) and water (6g). Irradiate (2 minutes, 5 minutes, 10 minutes, 15 minutes, 30 minutes) with ultraviolet lamp (120mw). The prepared colloid was washed with water for 5 times, and placed in a vacuum oven at 40° C. for 24 hours.

[0032] (2) Five parts of the same content of HEA (1.5g), PEGDA-200 (0.225g), N, N methylenebisacrylamide (0.225g), camphorquinone (CQ) and p-N, N-di The mixed solution of ethyl methylaminobenzoate (EDMAB) (0.03g) was ultrasonicated for 10 minutes, and 4-carboxy-4'-acryloyloxyazobenzene (0.015g, 0.03g, 0.045g, 0.06g, 0.075g) and water (6g). Irradiate (5 minutes, 10 minutes, 15 minutes, 30 minutes, 60 minutes) w...

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Abstract

The invention provides a method for preparing a photoresponse hydrogel containing azo monomers by utilizing light sources with different wavelengths, belonging to the field of hydrogels. The method comprises the step of: crosslinking acrylic ester and the activated azo monomers by a crosslinker through ultraviolet light or visible light to prepare the photoresponse hydrogels with different properties and release mechanisms, wherein the acrylic esters comprise hydroxy-ethyl acrylate (HEA) or hydroxyethyl methacrylate (HEMA); the structures of the activated azo monomers are shown as formula (I)and formula (II), wherein R1 and R2 are H, COOH and SO3H; and the crosslinker is N, N-methylene-bisacrylamide and water-soluble bifunctional acrylic esters and comprises polyethyleneglycol diacrylate(200, 400, 600, 800, 1000), wherein the R1 and the R2 are the H, the COOH and the SO3H. The invention has moderate condition and simple step and can be used for biomedicine aspects, i.e. drug controlled-release materials, tissue engineering, and the like.

Description

technical field [0001] The present invention relates to a new method for preparing photoresponsive hydrogels with different properties and release mechanisms, that is, through two different light sources of ultraviolet light and visible light, acrylate and reactive azo monomers are crosslinked with a crosslinking agent, Photoresponsive hydrogels with different properties and release mechanisms were prepared. The prepared photoresponsive hydrogels have potential wide applications in biomedicine, such as drug release and tissue engineering. Background technique [0002] Due to the irradiation of light sources of different wavelengths, the structure and properties of azobenzene will change accordingly. This remarkable feature has attracted a large number of researchers to study it. Smart hydrogels include temperature-sensitive hydrogels, pH-sensitive hydrogels, light-sensitive hydrogels, glucose-sensitive hydrogels, and electro-sensitive hydrogels. The most widely used therm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/28C08F220/38C08F220/34C08F2/50C08F2/46
Inventor 何勇刘建伟聂俊
Owner BEIJING UNIV OF CHEM TECH
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