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Cefpodoxime proxetil submicron emulsion solid preparation and novel application thereof

A technology of oxime ester submicron emulsion and cefpodoxime axetil, which is applied in the field of medicine, can solve problems such as poor stability and low dissolution rate, and achieve the effects of low cost, increased solubility, and improved stability

Inactive Publication Date: 2011-07-06
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The object of the present invention is to provide a kind of cefpodoxime axetil submicroemulsion solid preparation and its new application, more specifically, provide the solid preparation and its new application of the cefpodoxime axetil through microemulsification process, solve well Solved the problems of poor stability and low dissolution rate of cefpodoxime axetil solid preparations currently on the market, and also provided a drug that can be used for the preparation of drugs for the treatment of osteomyelitis of the jaw, and achieved satisfactory technical results

Method used

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  • Cefpodoxime proxetil submicron emulsion solid preparation and novel application thereof
  • Cefpodoxime proxetil submicron emulsion solid preparation and novel application thereof
  • Cefpodoxime proxetil submicron emulsion solid preparation and novel application thereof

Examples

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Effect test

Embodiment 1

[0042] The preparation of embodiment 1 cefpodoxime axetil submicron emulsion particles

[0043] Add 260g of cholesterol, 190g of Tween 80 and 125g of sodium deoxycholate into 4000ml of water for injection, then add 50g of cefpodoxime axetil and mix evenly, heat and stir in a water bath at 86°C until it melts, use a tissue masher to shear and stir for 10min, Rotating speed was 14000r / min to obtain primary emulsion, and then circulated and emulsified 4 times by high-pressure homogenizer to obtain emulsion, and then spray-dried to obtain 574g of submicron emulsion particles of cefpodoxime axetil, with a yield of 91.8%.

Embodiment 2

[0044] The preparation of embodiment 2 cefpodoxime axetil submicron emulsion particles

[0045] Add 350g of cholesterol, 120g of Tween 80 and 50g of sodium deoxycholate into 3000ml of water for injection, then add 100g of cefpodoxime axetil and mix evenly, heat and stir in a water bath at 90°C until it melts, use a tissue masher to shear and stir for 20min, The rotation speed was 12000r / min to obtain the first emulsion, which was emulsified 5 times by a high-pressure homogenizer to obtain an emulsion, then freeze-dried in a large plate, and pulverized to obtain 582g of submicron emulsion particles of cefpodoxime axetil, with a yield of 93.8%.

Embodiment 3

[0046] Example 3 Preparation of cefpodoxime axetil submicron emulsion particles

[0047] Add 800g of cholesterol, 600g of Tween 80 and 400g of sodium deoxycholate into 1500ml of water for injection, then add 100g of cefpodoxime axetil and mix evenly, heat and stir in a water bath at 75°C until it melts, use a tissue masher to shear and stir for 20min, Rotating speed was 13000r / min to obtain primary emulsion, and then circulated and emulsified by high-pressure homogenizer for 5 times to obtain emulsion, and then spray-dried to obtain 1752g of submicron emulsion particles of cefpodoxime axetil, with a yield of 92.2%.

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Abstract

The invention discloses a cefpodoxime proxetil submicron emulsion solid preparation and a novel application thereof, particularly a cefpodoxime proxetil solid preparation which is subjected to micro-emulsification and a novel application thereof. In the invention, the micro-emulsification technology is applied to process cefpodoxime proxetil raw materials so as to obtain a cefpodoxime proxetil submicron emulsion with excellent performance, the stability of the cefpodoxime proxetil is improved and the dissolution rate of the cefpodoxime proxetil preparation is obviously improved, so that the cefpodoxime proxetil submicron emulsion solid preparation has better bioavailability and can be used for preparing a medicament for treating osteomyelitis of jaws.

Description

technical field [0001] The invention relates to a submicron emulsion solid preparation of cefpodoxime axetil and its new application, in particular to a solid preparation of cefpodoxime axetil undergoing microemulsification treatment and its new application, belonging to the technical field of medicine. Background technique [0002] Osteomyelitis of the jaw is a disease caused by infection of the jaw, and the cumulative range often includes periosteum, cortex and bone marrow tissue. Clinically, suppurative osteomyelitis of the jaw, infantile osteomyelitis, and radiation osteomyelitis are common. Jaw osteomyelitis can be divided into suppurative, specific, radioactive several. Clinically, suppurative osteomyelitis is the most common. There are three main sources of infection in osteomyelitis of the jaw, namely odontogenic, traumatic and hematogenous. Hematogenous osteomyelitis of the jaw is rare and mainly occurs in children. Odontogenic jaw osteomyelitis is the most commo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/546A61K9/20A61K9/48A61K9/00A61P19/08A61P31/04
Inventor 王明
Owner HAINAN MEIDA PHARMA
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