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Medicinal composition for vagina

A composition and vaginal technology, which is applied in the directions of drug combinations, pharmaceutical formulas, and non-active ingredients medical preparations, etc., can solve the problems of reducing the patient's medication compliance, poor patient medication compliance, and short drug action time, and achieves the benefits of disease. Treatment, significant heat sensitivity, efficacy in improving medication compliance

Active Publication Date: 2011-07-20
JIANGXI ANGTAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1) easy to leak
After the common preparation is used, it is easy to leak out under the action of vaginal secretions and excretions. On the one hand, the drug will be lost and the curative effect cannot be guaranteed. Finally, the lying position is adopted, which brings great inconvenience to the patient and reduces the patient's compliance with medication.
[0008] 2) frequent use of medication
Due to the problems of leakage and fast drug release, the drug has a short action time in the vagina and low curative effect. Therefore, in most cases, it needs to be used once a day for 7 to 10 consecutive days, and the frequency of administration is frequent.
Frequent and multiple medications lead to poor drug compliance of patients, and some even cannot guarantee to complete the entire course of treatment, which affects the curative effect

Method used

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  • Medicinal composition for vagina
  • Medicinal composition for vagina

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1. pharmaceutical composition components are as follows:

[0062] Butoconazole Nitrate 2%

[0063] Polyethylene glycol 16%

[0064] Glycerin 8%

[0065] Poloxamer 407 22%

[0066] Hypromellose K15M 1%

[0067] Carbomer 940 0.2%

[0068] Methylparaben 0.1%

[0069] Propylparaben 0.1%

[0070] water balance

[0071] Preparation:

[0072] 1. Take methylparaben and propylparaben, add water and continue to stir to dissolve, add carbomer while stirring, add hypromellose and poloxamer after dissolution, and place it at 4°C to make Sufficient swelling, as a gel matrix;

[0073] 2. Add butoconazole nitrate into polyethylene glycol and glycerin, stir for 2 hours, and use it as a liquid containing medicine;

[0074] 3. While stirring, add the drug-containing solution into the gel matrix, mix evenly, adjust the pH to 3-7 with 0.1mol / l NaOH solution and 0.1mol / l HCl solution if necessary, and pack it into the vaginal applicator , 5g each, that is.

Embodiment 2

[0075] Embodiment 2. The pharmaceutical composition components are as follows:

[0076] Butoconazole Nitrate 2%

[0077] Hydroxypropyl Beta Cyclodextrin 32%

[0078] Poloxamer 407 15.5%

[0079] Hypromellose K100M 0.6%

[0080] Carbomer 974 0.1%

[0081] Methylparaben 0.12%

[0082] Propylparaben 0.06%

[0083] water balance

[0084] Preparation:

[0085] Take carbomer, add water and continue stirring to dissolve, add butoconazole nitrate, hydroxypropyl beta cyclodextrin, methylparaben, propylparaben, add poloxamer, hypromellose while stirring Cellulose, placed at 4°C, after fully swollen, if necessary, use 0.1mol / l NaOH solution and 0.1mol / l HCl solution to adjust the pH to 4-6, and pack it in a vaginal applicator, 5g per Branch, that is.

Embodiment 3

[0086] Embodiment 3. pharmaceutical composition components are as follows:

[0087] Butoconazole Nitrate 2%

[0088] Hydroxypropyl Beta Cyclodextrin 25%

[0089] Poloxamer 407 18%

[0090] Hypromellose K100M 0.3%

[0091] Carbomer 980 0.1

[0092] Propylene Glycol 5%

[0093] Methylparaben 0.1%

[0094] Propylparaben 0.5%

[0095] water balance

[0096] Preparation:

[0097] Take butoconazole nitrate, hydroxypropyl beta cyclodextrin, methylparaben, propylparaben, add water and propylene glycol, mix well and continue stirring to dissolve, while stirring, add carbomer, poloxamer, Hypromellose, placed at 4°C, after fully swelling, if necessary, use 0.1mol / l NaOH solution and 0.1mol / l HCl solution to adjust the pH to 3-7, and pack it into the vaginal applicator , 5g each, that is.

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Abstract

The invention relates to a medicinal composition for vagina. The composition comprises butoconazole nitrate, poloxamer, hydroxypropyl methylcellulose, Carbomer and other additives. The composition has the characteristics of good vagina mucosa adhesion and long-acting slow release, and in vivo and in vitro experiment results prove that the composition can continuously release the medicament for more than 72 hours.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a vaginal pharmaceutical composition. Background technique [0002] Gynecological inflammation is a common disease in women. About 87% of adult women in the world have been infected with gynecological inflammation to varying degrees. Common clinical gynecological inflammations include vaginitis, cervicitis, pelvic inflammatory disease, endometritis, etc. Among them, the incidence of vaginitis The highest, accounting for about one-third of gynecological inflammation. Vaginitis is mainly divided into fungal vaginitis, bacterial vaginosis, and trichomonas vaginitis, among which the incidence of bacterial vaginosis and fungal vaginitis is relatively high. With the improvement of living standards, the incidence of trichomonas vaginitis Greatly reduced. Mycotic vaginitis is mainly caused by Candida, so it is also called Candida vaginitis. According to statistics, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4174A61K47/38A61P31/10A61P15/02
Inventor 常建晖邓文军巩洪刚邓树海
Owner JIANGXI ANGTAI PHARMA
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