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Hydrogel with pH sensibility and temperature sensibility and preparation method thereof

A hydrogel and sensitive technology, applied in the field of sensitive hydrogel, hydrogel with pH and temperature dual sensitivity and its preparation, can solve the controversial issues of biological safety, achieve good intelligence, good Mechanical properties, the effect of simple synthesis method

Inactive Publication Date: 2010-05-05
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Most temperature-sensitive hydrogels use temperature-sensitive N-isopropylacrylamide (NIPAM) as the temperature-sensitive material. The minimum critical transition temperature of polyisopropylacrylamide (PNIPAM) is 32 °C, but due to the In the hydrogel system prepared with isopropylacrylamide as a monomer, isopropylacrylamide is a network-like polymer, and its biological safety is still controversial.

Method used

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  • Hydrogel with pH sensibility and temperature sensibility and preparation method thereof
  • Hydrogel with pH sensibility and temperature sensibility and preparation method thereof
  • Hydrogel with pH sensibility and temperature sensibility and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Hydroxypropyl cellulose and acrylic acid copolymerization pH and temperature dual sensitive hydrogel

[0033] 1g of hydroxypropyl cellulose and 0.01g of acrylic acid were dissolved in 30ml of chloroform, 0.028g of N,N-dicyclohexylcarboimide (DCC) and 0.0016g of 4-dimethylaminopyridine were added, and condensed at room temperature for 72 hours. The reaction product was centrifuged to get the clear liquid, and then vacuum filtered with a G4 sand core funnel. The obtained solution was settled with cold ether, and the product was dissolved in ether with chloroform to settle, and then vacuum-dried. Dissolve 4 mg of the obtained cellulose acrylate and 396 mg of acrylic acid monomer in 4 ml of deionized water, and after bubbling with argon for 30 minutes, add 20 mg of ammonium persulfate (APS), 10 ul of tetramethylethylenediamine (TEMED), and react at 25°C 24 hours. After the reaction, the reactant was put into a beaker containing one liter of deionized water, and the water w...

Embodiment 2

[0035] Hydroxypropyl cellulose and acrylic acid copolymerization pH and temperature dual sensitive hydrogel

[0036]1 g of hydroxypropyl cellulose and 0.29 g of acrylic acid were dissolved in 30 ml of chloroform, 0.84 g of N,N-dicyclohexylcarboimide (DCC) and 0.05 g of 4-dimethylaminopyridine were added, and condensed at room temperature for 72 hours. The reaction product was centrifuged to get the clear liquid, and then vacuum filtered with a G4 sand core funnel. The obtained solution was settled with cold ether, and the product was dissolved in ether with chloroform to settle, and then vacuum-dried. Dissolve 4 mg of the obtained cellulose acrylate and 396 mg of acrylic acid monomer in 4 ml of deionized water, and after bubbling with argon for 30 minutes, add 20 mg of ammonium persulfate (APS), 10 ul of tetramethylethylenediamine (TEMED), and react at 25°C 24 hours. After the reaction, the reactant was put into a beaker containing one liter of deionized water, and the water ...

Embodiment 3

[0038] Hydroxypropyl cellulose and acrylic acid copolymerization pH and temperature dual sensitive hydrogel

[0039] 1 g of hydroxypropyl cellulose and 0.29 g of acrylic acid were dissolved in 30 ml of chloroform, 0.84 g of N,N-dicyclohexylcarboimide (DCC) and 0.25 g of 4-dimethylaminopyridine were added, and condensed at room temperature for 72 hours. The reaction product was centrifuged to get the clear liquid, and then vacuum filtered with a G4 sand core funnel. The obtained solution was settled with cold ether, and the product was dissolved in ether with chloroform to settle, and then vacuum-dried. Dissolve 396 mg of the obtained cellulose acrylate and 4 mg of acrylic acid monomer in 4 ml of deionized water, and then add 20 mg of ammonium persulfate (APS) and 10 ul of tetramethylethylenediamine (TEMED) after passing through argon for 30 minutes, and react at 25°C 24 hours. After the reaction, the reactant was put into a beaker containing one liter of deionized water, and ...

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Abstract

The invention belongs to the technical field of high polymer materials, and relates to a sensible hydrogel, in particular to a hydrogel with pH sensibility and temperature sensibility and a preparation method thereof. The preparation method comprises the following steps: synthesizing hydroxy propyl cellulose and acrylic acid or acryloyl chloride into acrylic acid cellulose ester and copolymerizing the prepared acrylic acid cellulose ester and acrylic acid monomer to form the hydrogel. The hydrogel comprises hydroxy propyl cellulose chain segment with pH sensibility and temperature sensibility and acrylic acid chain segment with pH sensibility, and meanwhile, the hydrogel has pH sensibility, temperature sensibility and degradability and flexible responsiveness to the pH, can rapidly generate volume expansion or contraction, and has favorable mechanical property, good intellectuality and easy and feasible synthetic method, and the temperature sensibility is influenced by the pH value of the solution.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and relates to a sensitive hydrogel, in particular to a pH- and temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] Polymer hydrogel material refers to a material with a low cross-linking degree that can quickly absorb and maintain a large amount of water and is insoluble in water. It has the characteristics of a polymer electrolyte and a three-dimensional network structure. And the rapid development of functional polymer materials. [0003] Environmentally sensitive polymer hydrogel, also known as intelligent hydrogel, is a type of hydrogel that can respond sensitively to external stimuli. External stimuli can be temperature, pH value, solvent, salt concentration, light, chemical substances, etc. . According to the response to external stimuli, intelligent hydrogels are divided into: temperature-responsive hydrogels, pH-responsive hydrogels,...

Claims

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Application Information

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IPC IPC(8): C08F251/02C08B13/00
Inventor 陈莉张哲陈学思庄秀丽白云艳单红玲
Owner NORTHEAST NORMAL UNIVERSITY
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