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Microscale reactor for synthesizing radioactive drug and application thereof

A micro-reactor, radiopharmaceutical technology, applied in laboratory containers, preparation of organic compounds, introduction of isotopes into organic compounds, etc., can solve problems such as difficulty in reducing costs, large reaction volume, and many synthetic reagents, and reduce consumption. , The process method is simple and easy to implement, the effect of reducing space and capital investment

Inactive Publication Date: 2010-04-28
FUDAN UNIV SHANGHAI CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current domestic radiolabeled synthesis equipment has a large reaction volume and requires many synthetic reagents, which makes it difficult to reduce the cost of positronium drug synthesis

Method used

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  • Microscale reactor for synthesizing radioactive drug and application thereof
  • Microscale reactor for synthesizing radioactive drug and application thereof
  • Microscale reactor for synthesizing radioactive drug and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Labeled synthesis of 18F-deoxyglucose ( Figure 9 ):

[0053] Since in the microfluidic chip of the present invention, the power of liquid flow comes from pneumatic pressure, the amount of reagents added is quantitative, that is, the reagents to participate in the reaction are added to the corresponding pipelines in advance, and the addition of reagents is an "all or nothing" formula, That is, either all of them are added, or they are not added at all, and there is no intermediate form. The air pressure of the liquid is 20-40Kpa, and the air pressure of the gas control valve is 60-150Kpa.

[0054] When the equipment is in the ready state, the Q1, Q2-Q13 pipes are all pressurized at 60-90Kpa, and all valves are closed at this time. The adsorption column 50 is pre-rinsed with 100ul of 0.5M K2CO3 solution, and then washed with 500ul of water until neutral. The liquid pipeline distributes and loads the corresponding reagents, that is, Y1: 500ul, 18F-H2O; Y2: w...

Embodiment 2

[0063] Example 2: Synthesis of 18F-fluoroacetate (18FAC) ( Figure 12 )

[0064] The air pressure of the liquid is 20-40Kpa, and the air pressure of the gas control valve is 60-150Kpa. When the equipment is in the ready state, the Q1, Q2-Q13 pipes are all pressurized at 60-90Kpa, and all valves are closed at this time. The adsorption column 50 is pre-rinsed with 100ul of 0.5M K2CO3 solution, and then washed with 500ul of water until neutral. The liquid pipeline distributes and loads the corresponding reagents, that is, Y1: 500ul, 18F-H2O; Y2: waste liquid bottle; Y3: 20ul eluent (K222, 300mg / K2CO3, 55mg / 0.5mlH2O / 19.5mlMeCN); Y4: 20ul anhydrous Acetonitrile; Y5: 20ul O-ethylglycolate methanesulfonate EOMG (5ulEOMG / 500ul anhydrous acetonitrile); Y6: 100ul water; Y7: 40ul, 1N NaOH: Y8: 80ul, 0.5N HCl; Y10: 200ul of water; Y11: waste liquid bottle (empty); In addition, the outlet of the Y9 pipeline is connected to the adsorption hydrolysis column Oasis-HLB (diameter 2.5×15mm). ...

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Abstract

The invention relates to the technology of microscale reactor, in particular to a microscale reactor for synthesizing radioactive drug. The microscale reactor is composed of a sealing-in body, a reaction flask, a separation column and an adsorption column, wherein the sealing-in body is sealed by a fluid channel layer, a middle layer and a control channel layer into a whole; the reaction flask, the separation column and the adsorption column are detachably spliced into the sealing-in body. The fluid passage layer comprises a fluid microchannel which causes fluid to communicate with each reaction flask, the separation column and the adsorption column; the control channel layer comprises a control air microchannel and an air chamber corresponding to the fluid microchannel; a microvalve is composed of an air chamber and a middle layer to control the fluid microchannel to open and close. The microfluidic chip of the invention can synthesize common positron nuclide of microscale volume. The invention has simple and easy preparation technology method, needs no expensive equipment, can reduce space and invested capital for protecting equipment for preparing radioactive drug and can reduce the workload of experimenters.

Description

technical field [0001] The invention relates to micro-reactor technology, in particular to a micro-fluidic reactor suitable for synthesizing positron nuclide radiopharmaceuticals and the application of the micro-fluidic reactor. Background technique [0002] Micro-fluidic Chip (Micro-fluidic Chip) or lab on a chip (Lab on a chip) is a new technology developed on the basis of micro-electromechanical system technology. It has attracted people's attention in recent years. Its technology has been widely used in many analytical fields such as disease diagnosis, drug screening and environmental detection. In the prior art, materials for making microfluidic diagnostic chips mainly include polymer materials such as PDMS (Polydimethylsiloxane, Polydimethylsiloxane), which have the advantages of convenient processing and molding, low price, and can be mass-produced cheaply. [0003] The synthesis of radiopharmaceuticals, especially positron nuclide drugs, is very suitable for the app...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00B01L3/00C07B59/00C07H5/02C07H1/00C07C53/18C07C51/363
CPCY02P20/141
Inventor 张勇平章英剑王明伟
Owner FUDAN UNIV SHANGHAI CANCER CENT
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