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Stable nano graphene oxide under physiological condition and preparation method thereof

A physiological condition, nanotechnology, applied in the fields of nanostructure manufacturing, nanotechnology, nanotechnology, etc., can solve the problems of high cost, low output, restricting graphene research and application, etc., to facilitate mass production, reduce manufacturing costs, improve The effect of stability

Active Publication Date: 2010-04-07
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Application Information

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Problems solved by technology

However, this method is costly and yields low
Limiting the research and application of graphene in biomedicine and other fields

Method used

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  • Stable nano graphene oxide under physiological condition and preparation method thereof
  • Stable nano graphene oxide under physiological condition and preparation method thereof
  • Stable nano graphene oxide under physiological condition and preparation method thereof

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Embodiment Construction

[0014] In order to improve the stability of nano-graphene oxide under physiological conditions, and mass-produce it at low cost to meet the needs of its in-depth research in the fields of biomedicine and other fields, the present invention provides a Nano-graphene oxide with sufficient stability, based on the original finished product, the nano-graphene oxide also contains two hydrophilic groups of acetic acid functional group and sulfonic acid functional group through further chemical modification. Such as image 3 The infrared spectrum of the nano-graphene oxide can prove that the acetic acid functional group and the sulfonic acid functional group are successfully connected to the nano-graphene oxide.

[0015] The preparation method of nano-graphene oxide of the present invention will be described in detail below through specific examples.

[0016] Such as figure 1 As shown in the process flow chart of the preparation method of the present invention, it can be seen that th...

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Abstract

The invention discloses a stable nano graphene oxide under physiological condition, which is characterized in that: based on the prior finished product, the nano graphene oxide also contains two types of hydrophilic groups, namely carboxylic acid functional group and sulfonic acid functional group, by further chemically modification. Firstly, crystalline flake graphite is oxidized by adopting a Hummer method; secondly, graphene oxide is peeled off by an ultrasonic method; thirdly, the graphene oxide is fragmented into nano size by an ultrasonic probe method; and finally, carboxylic acid modification is performed on the nanoscale graphene oxide by an immersion ultrasound method, carboxyl functional groups are introduced, benzene sulfonation modification is performed on the graphene oxide, and sulfonic acid groups are introduced on the edge of the graphene oxide. The nano graphene oxide can improve the stability of graphene oxide in saline solution or cell culture media, and a powerful guarantee for the medicinal application of nano graphene oxide under physiological condition is provided. Compared with the polyethylene glycol modification method, the method has the advantages of reducing manufacture cost and facilitating mass production.

Description

technical field [0001] The invention relates to a nano-carbon compound, in particular to a nano-graphene oxide with good stability under physiological conditions and a preparation method thereof. Background technique [0002] Nanomaterials have broad application prospects in the field of biomedicine. One of the important uses is that it is used as a carrier to deliver drugs to specific organs and tissues in the human body, thereby playing the role of targeted therapy. Nanomaterials used in drug-loading systems must have good biocompatibility and low biotoxicity, and be stable under physiological conditions without aggregation. These requirements are generally achieved by surface modification of nanomaterials. At present, the more commonly used surface modification is to modify the surface of nanomaterials with polyethylene glycol. The biocompatibility and stability under physiological conditions of the obtained nanomaterials are significantly improved. However, this meth...

Claims

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Application Information

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IPC IPC(8): B82B1/00B82B3/00
Inventor 张智军张立明夏景光
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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