Mixed brain white matter nerve fiber automatic cluster and marking method

Abstract

The invention relates to a mixed brain white matter nerve fiber automatic cluster and a marking method. The marking method is characterized in that: firstly, using a high dimensional elastic registration method to match a standard brain atlas to a single brain space, thereby being capable of dividing a single brain into 104 anatomical regions with structural information; secondly, using differentnerve fiber bundles to extract and mark 15 nerve fiber bundles according to the characteristics of different brain anatomical regions; thirdly, to other 4 nerve fiber bundles which can not be extracted by the above method due to strong winding between the 4 nerve fiber bundles and the nerve fiber bundles at the periphery thereof, using a method combing Kernel-PCA and Fuzzyc-mean and based on similarity measurement to automatically carry out clustering analysis; and at last, using an identification method based on characteristics to mark the result of clustering analysis. By the above method, 19 main white matter nerve fiber bundles of the brain can be extracted and marked automatically.

Description

technical field [0001] The invention relates to a method for automatic clustering and marking of mixed brain white matter nerve fibers, and belongs to the field of medical image processing where the image modality is diffusion tensor nuclear magnetic resonance image (DT-MRI). It is suitable for medical imaging diagnosis based on nerve fiber bundles, analysis of brain structure and function, research on brain development and neurodegenerative diseases, etc. Background technique [0002] DT-MRI diffusion tensor nuclear magnetic resonance images provide a description of the direction and structure of brain nerve fibers, and are currently the only medical imaging technology that can be used to observe brain white matter nerve fibers in vivo. The analysis of brain white matter nerve fibers based on DT-MRI not only provides a tool for direct visual observation of brain nerve fiber bundles, but also enables the quantification of brain white matter nerve fibers by combining differen...

AI Technical Summary

Problems solved by technology

At present, the diffusion tensor nuclear magnetic resonance image is processed, and the nerve fiber tracking of the DTI image is performed using DTIStudio, and the nerve fiber connected by a series of pixel points and the whole white matter nerve fiber map of the brain expressed by a series of nerve fibers can be obtained. However, thousands of nerve fibers without organization and labeling are difficult to satisfy research based on nerve fiber bundles with bioanatomical significance, making it impossible for medical researchers to recognize and identify numerous nerve fibers, and it is also impossible to integrate the brain White matter nerve fiber maps are good for medical research

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