Fritillary-loquat medicinal composition and preparation method thereof

A technology of Chuanbei loquat and its composition, which is applied in the field of traditional Chinese medicine composition and its preparation process, to achieve the effects of enhancing drug efficacy, convenient manufacture, and simple preparation process

Inactive Publication Date: 2010-02-03
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Another object of the present invention is to develop a method for preparing the Chuanbei loquat composition with excellent performance and in line with the standard of the "Pharmacopoeia of the People's Republic of China" by using the four medicinal materials in the composition as raw materials, and overcome the problem of making The disadvantages of high cost and low bioavailability improve product quality, reduce costs, facilitate taking, and better meet medical needs and the utilization of raw materials

Method used

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  • Fritillary-loquat medicinal composition and preparation method thereof
  • Fritillary-loquat medicinal composition and preparation method thereof
  • Fritillary-loquat medicinal composition and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0072] Use 65g of Fritillaria chinensis, 65g of Platycodon grandiflorum, 430g of loquat leaves, 0.5g of menthol and four herbs as raw materials; crush 65g of Fritillaria chinensis into fine powder passing through a 100-mesh sieve for later use, and crush 65g of Platycodon grandiflorum into fine powder passing through a 100-mesh sieve. powder, take 48g of bellflower fine powder for later use, mix the remaining bellflower powder with 430g of loquat leaves, add water and decoct twice, add 10 times the amount of water of the mixture for the first time, and cook for 1 hour; add 8 times of the mixture for the second time amount of water, decocted for 1 hour, filtered several times, combined the filtrates, and stood still for 12 hours, took the supernatant and concentrated it to a clear paste with a relative density of 1.20-1.25 (60°C), and added 48g of platycodon grandiflorum to the clear paste. Powder, mix, dry, grind, add Fritillaria fine powder, mix, granulate, dry, add menthol 0....

Embodiment 2

[0074] Use 50g of Fritillaria chinensis, 50g of Platycodon grandiflorum, 330g of loquat leaves, 0.35g of menthol and four herbs as raw materials; crush 50g of Fritillaria chinensis into fine powder passing through a 120-mesh sieve for later use, and crush 50g of Platycodon grandiflorum into fine powder passing through a 120-mesh sieve. powder, take 36.9g bellflower fine powder for later use, mix the remaining bellflower powder with 330g loquat leaves, add water and decoct twice, add 8 times the amount of water of the mixture for the first time, and cook for 1 hour; add 6 times of the mixture for the second time times the amount of water, decocted for 0.5 hours, filtered several times, combined the decoction, stood still for 10 hours, took the supernatant and concentrated it to a clear paste with a relative density of 1.20-1.25 (60°C), and added 36.9 g bellflower fine powder, mix well, dry, grind finely, add Chuan Fritillaria fine powder, mix well, granulate, dry, add menthol 0....

Embodiment 3

[0076] Use 90g of Fritillaria chinensis, 90g of Platycodon grandiflorum, 600g of loquat leaves, 0.7g of menthol and four herbs as raw materials; crush 90g of Fritillaria chinensis into fine powder passing through a 150 mesh sieve for later use, and crush 90g of Platycodon grandiflorum into fine powder passing through a 150 mesh sieve. powder, take 66.5g bellflower fine powder for later use, mix the remaining bellflower powder with 600g loquat leaves, add water and decoct 3 times, add 12 times the amount of water of the rest bellflower powder and loquat leaf mixture for the first time, and cook for 1.5 hours; Add 10 times the amount of water of the mixture for the second time, decoct for 1 hour; add 8 times the amount of water of the mixture for the third time, decoct for 0.5 hours, filter in several times, combine the decoctions, let stand for 14 hours, and take the supernatant Concentrate the liquid to a clear paste with a relative density of 1.20-1.25 (60°C), add 66.5g of bel...

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Abstract

The invention relates to a fritillary-loquat medicinal composition and a preparation method thereof. The preparation method comprises the following steps: selecting and using four gouts of raw material medicines comprising fritillary bulb, platycodon root, loquat leaf and menthol; and crushing the fritillary bulb into fine powder for later use, then crushing the platycodon root into fine powder, taking certain amount of platycodon root fine powder for later use, mixing the rest platycodon root powder and the loquat leaf and decocting the mixture by adding water, gradually filtering the decoction, combining the filtrate, keeping the filtrate standing, concentrating supernatant into clear paste, adding the platycodon root fine powder into the paste, then evenly mixing, drying and grinding the mixture, adding the fritillary bulb fine powder into the mixture, evenly mixing, granulating and drying the mixture, adding the menthol and auxiliary materials into the mixture, and evenly mixing the mixture to form various dosage forms according to clinical requirement. The medicament of the invention adopts nontoxic pure Chinese medicinal raw materials; the medicament prepared by the process is easy to be absorbed; the utilization rate of effective components of the medicament is higher; and the medicament is convenient to eat and carry and has low manufacturing cost. If one third of the fritillary bulb fine powder is extracted by 70 percent ethanol firstly and then subsequent operation is carried out, the prepared medicament has better treatment effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and the field of preparation technology thereof, more specifically to a Chuanbei loquat medicinal composition and a preparation method thereof. Background technique [0002] Chuanbei loquat syrup published in the 2000 edition is a commonly used medicine traditionally used to treat colds, coughs and bronchitis. Its prescription is 45ml of Chuanbeimu liquid extract, 45g of bellflower, 300g of loquat leaves, and 0.34g of menthol. Its preparation method is to take 45g of Fritillaria sichuanensis fluid extract system, grind it into a coarse powder, follow the percolation method (Appendix 10) under the liquid extractant and extractant, use 70% ethanol as solvent, and soak it after 5 days , slowly percolate, collect 38ml of the first eluate, store it in another device, continue to percolate, until the soluble components are completely expelled, the second eluate is concentrated to an appropri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P11/00A61P11/14A61K31/045
Inventor 唐德江陈犁
Owner 重庆希尔安药业有限公司
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