Method for detecting chemical or biological substance

Abstract

The invention pertains to the field of micro-trace chemical substance detection, relates to a method for detecting chemical or biological substance. The method includes making the sample solution in contact with the nano-scale surface structure in the probe, wherein the nano-scale surface structure includes a plurality of columns on the substrate, a plurality of pores in the substrate, or a plurality of nano-particles in the sample solution; irradiating the sample solution on the nano-scale surface structure of the probe with a laser beam; obtaining the Raman spectrum from the scattered light by a spectrum analyzer; recognizing spectrum signal in the Raman spectrum and whether special chemical or biological substances is included in the sample solution. The sample solution can be sample solution from food, or body fluid from human body. The invention provides a simple and non-invasive detection method, which is easy for operation, applicable in counter-terrorism, criminal investigation, medical diagnosis, disease prevention, industrial process monitoring, environment cleaning and monitoring, counterfeit goods detection, product identification, detection of methanol and ethanol content in alcohol, quality control of food and medicament or the like.

Description

[0001] This application claims priority from US Patent Application No. 12 / 176,383, US Patent Application No. 12 / 246,616 and US Patent Application No. 12 / 403,522. Among them, US 12 / 403,522 patent application is a continuation-in-part (CIP) application of pending US 12 / 176,383 patent application and US 12 / 246,616 patent application. The title of US12 / 246,616 patent application is "system and method applied to food safety detection", and the application date is October 7, 2008; Diagnosing Diseases with Instruments", the filing date was July 20, 2008. U.S. Patent Application No. 12 / 176,383 is part of commonly assigned U.S. Patent Application No. 11 / 681,157 (now issued as U.S. Patent No. 7,428,046), filed March 1, 2007, entitled "Trace Chemical Optical Probes" Continuation of patent application. US Patent Application No. 11 / 681,157 is a continuation of commonly assigned US Patent Application No. 10 / 987,842 (now issued as US Patent No. 7,242,469). US Patent Application No. US10 / 987...

AI Technical Summary

Problems solved by technology

Conventional Raman scattering detectors are currently limited in application due to technical difficulties

A major limitation in the application of Raman spectroscopy is that the Raman scattering signals obtained from micro-trace amounts of chemicals are very weak

Numerous efforts have been made to enhance the intensity of the Raman scattering signal, however, these efforts have still failed to make detector-based Raman spectroscopy practical and economical, despite the current urgent need in many fields. Technologies such as anti-terrorism, forensic investigation, medical diagnosis, disease prevention, industrial process monitoring, environmental cleanup and monitoring, food inspection, anti-counterfeiting and drug quality control, etc.

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