Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chicken coccidia powder and preparation method thereof

A chicken coccidiostat, weight ratio technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of unstable product quality, instability, and high drug costs

Active Publication Date: 2009-11-18
GUANGDONG VTR BIO TECH
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the traditional Chinese medicines containing artemisinin (artemisinin, the main component of Artemisia annua, which has a strong antiprotozoal effect), have the following limitations: unstable product quality, unstable at high temperature (artemisinin It is thermally unstable and decomposes above 60°C), while the temperature of feed pelleting is around 90°C, so the content of artemisinin in this type of product is greatly reduced, and the dosage is large (the addition ratio in feed is 1~2%), the cost of medication is high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chicken coccidia powder and preparation method thereof
  • Chicken coccidia powder and preparation method thereof
  • Chicken coccidia powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0174] Artemisia annua 400Kg, Changshan 200Kg, verbena 200Kg, talcum powder 100Kg, flavescens 100Kg, β-cyclodextrin 64Kg. The preparation steps are as follows:

[0175] (1) Get Changshan, Verbena, Sophora flavescens and carry out ultrafine pulverization with a 600 mesh sieve, for subsequent use;

[0176] (2) The dried stems and leaves of Artemisia annua are crushed into coarse powder, add 3 times of petroleum ether to reflux and extract 4 times, each time for 1 hour, filter while hot, combine the filtrate, reflux petroleum ether under reduced pressure to the extract, add 10 times to the extract Melt in 70% ethanol, reflux and decolorize with 2.5% activated carbon for 1 hour, concentrate to extract, and dry at 60°C to obtain artemisinin; Mix; then add dropwise at a uniform speed to saturated β-cyclodextrin with a rotating speed of 500r / m, the molar ratio of artemisinin to cyclodextrin is 1:1, stir for 4 hours after the addition, and put it in a refrigerator at 4°C for refriger...

Embodiment 2

[0179] Artemisia annua 300Kg, Changshan 100Kg, Verbena 100Kg, talcum powder 50Kg, Sophora flavescens 50Kg, β-cyclodextrin 24Kg. The preparation steps are as follows:

[0180] (1) Get Changshan, Verbena, Sophora flavescens and carry out ultrafine pulverization with a 600 mesh sieve, for subsequent use;

[0181] (2) The dried stems and leaves of Artemisia annua are crushed into coarse powder, add 3 times of petroleum ether to reflux and extract 4 times, each time for 1 hour, filter while hot, combine the filtrate, reflux petroleum ether under reduced pressure to the extract, add 5 times to the extract Melt in 70% ethanol, reflux and decolorize with 2.5% activated carbon for 1 hour, concentrate to extract, and dry at 60°C to obtain artemisinin; Mix; then add dropwise at a uniform speed to saturated β-cyclodextrin with a rotating speed of 500r / m, the molar ratio of artemisinin to cyclodextrin is 1:1, stir for 4 hours after the addition, and put it in a refrigerator at 4°C for ref...

Embodiment 3

[0184] Take Artemisia annua 800Kg, Changshan 200Kg, Verbena 400Kg, Talcum powder 100Kg, Sophora flavescens 100Kg, β-cyclodextrin 64Kg. The preparation steps are as follows:

[0185] (1) Radix Changshan, Verbena, Sophora flavescens are ultrafinely pulverized with a 600 mesh sieve, and set aside;

[0186] (2) The dried stems and leaves of Artemisia annua are crushed into coarse powder, and 5 times of petroleum ether is added to reflux to extract 4 times, each time for 1 hour, filtered while hot, the filtrate is combined, and the petroleum ether is refluxed under reduced pressure to the extract, and the extract is added 10 times Melt in 70% ethanol, reflux and decolorize with 2.5% activated carbon for 1 hour, concentrate to extract, and dry at 60°C to obtain artemisinin; Mix; then add dropwise at a uniform speed to the saturated β-cyclodextrin with a rotational speed of 500r / m, the molar ratio of artemisinin and cyclodextrin is 1:1, stir for 8 hours after the addition, and put i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a chicken coccidia powder with low toxicity, high anticoccidial index and low drug application cost and used for resisting chicken coccidiosis, and a preparation method thereof. The chicken coccidia powder contains 400 parts of southernwood, 200 parts of dichroa, 200 parts of verbena, 100 parts of talcum powder, 100 parts of sophorae Flavescentis, and 64 parts of beta-cyclodextrin, by weight; the preparation method of the chicken coccidia powder comprises the steps of: fetching the dried stems and leaves of the southernwood, crushing the dried stems and leaves of the southernwood into crude powder, adding petroleum ether for reflux extraction for four times, fetching and combining filtrate, decompressing-refluxing the petroleum ether to extractum which is then added with 70% ethanol for thermally dissolving and 2.5% activated carbon for reflux decolourization, later conducting concentration to extractum, and drying at temperature of 60 DEG C for obtaining artemisinin; after crushing, mixing with acetone; then dropping the mixture into saturated beta-cyclodextrin at constant speed, stirring, refrigerating, and separating out crystals; conducting suction filtration; washing the sediments with purified water, and drying in a drying cabinet at the temperature of 60 DEG C to obtain an artemisinin-beta-CD clathrate compound; and finally evenly mixing and packing the clathrate compound with the talcum powder and superfine-pulverized dichroa, verbena and sophorae Flavescentis.

Description

technical field [0001] The invention relates to chicken coccidiosis powder for resisting chicken coccidiosis and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a protozoan parasitic disease caused by Eimeriaceae. Chicken coccidiosis mainly parasitizes chicken intestines, and some coccidia parasitize chicken livers. The incidence of coccidia is characterized by mixed infection of various types of coccidiosis, and mixed infection with other diseases, which induces other diseases; coccidiosis is characterized by high concentration of drug resistance, cross-resistance, and multi-drug resistance. (Refer to "the reasons and countermeasures of chicken coccidiosis difficult to control" in the 03rd issue of "China Poultry Industry Guide" in 2009). The occurrence of coccidiosis leads to intestinal hemorrhage, intestinal mucosal damage, mild cases lead to malnutrition of chickens, slow growth, severe cases lead to the death of chickens, and bring se...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/85A61K9/14A61P33/02A61K33/12
Inventor 孟琼华林林
Owner GUANGDONG VTR BIO TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com