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Houttuynia-honeysuckle ophthalmic instant-type gel and preparation method thereof

An ophthalmic and gel technology, applied in the field of ophthalmic ready-to-type gel preparations, can solve the problems of short duration of drug efficacy and low bioavailability of eye drops, and achieve good in vitro antibacterial effect and good in vitro antiviral effect Effect

Inactive Publication Date: 2009-11-18
北京法玛赛科医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Currently, only Yujin Injection is the only drug on the market that uses Houttuynia cordata and honeysuckle as raw materials. Although there are reports in the literature that Yujin eye drops are made from Houttuynia cordata and honeysuckle, the eye drops have low bioavailability, The short duration of drug effect and other disadvantages, so the development of new preparations for ichthyophthora will have good social and economic benefits

Method used

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  • Houttuynia-honeysuckle ophthalmic instant-type gel and preparation method thereof
  • Houttuynia-honeysuckle ophthalmic instant-type gel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Prescription Houttuynia cordata 4000g Honeysuckle 2000g

[0042] Take Houttuynia cordata medicinal material, add 8 times the amount of distilled water, after wetting, steam distillation to extract the volatile oil for 5 hours, take the volatile oil for later use; take β-cyclodextrin, add distilled water to make a saturated solution, add slowly at 40°C Houttuynia cordata volatile oil dissolved in ethanol, the amount of cyclodextrin and volatile oil is controlled at 6:1 (g:ml), stirred at constant temperature for 2 hours, placed in the refrigerator overnight, suction filtered, dried below 40 ° C, Houttuynia cordata Volatile oil clathrate.

[0043] Take the honeysuckle medicinal material, add 8 times the amount of hot water to moisten it, extract twice at 80°C, filter, combine the filtrates, concentrate under reduced pressure, so that the volume of the medicinal liquid and the weight of the medicinal material are 1:1 (ml:g), centrifuge at a high speed, add onto the treate...

Embodiment 2

[0046] Prescription Houttuynia cordata 4000g Honeysuckle 2000g

[0047]Take Houttuynia cordata medicinal material, add 12 times the amount of distilled water, after wetting, steam distillation to extract volatile oil for 5 hours, take the volatile oil for later use; take honeysuckle medicinal material, add 10 times the amount of hot water to moisten, leaching twice at 90 °C, filter After that, the filtrates were combined, concentrated under reduced pressure, so that the volume of the medicinal solution and the weight of the medicinal material were 1:1 (ml:g), centrifuged at a high speed, added to the treated macroporous adsorption resin AB-8, rinsed with water first, and then used Rinse with 40% ethanol, collect the 40% ethanol eluate, recover the ethanol under reduced pressure, and concentrate to dryness under reduced pressure to obtain the total organic acid extract of Lonicera japonica.

[0048] Take the volatile oil of Houttuynia cordata, dissolve it with appropriate amoun...

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Abstract

The invention relates to a temperature-sensitive ophthalmic instant-type gel for treating ocular bacterial or virus infection, and a preparation method thereof. The ophthalmic instant-type gel is prepared mainly by taking houttuynia volatile oil and honeysuckle total organic acids as effective components. Meanwhile, the invention also discloses a method for preparing the preparation. The method ensures higher content of the effective components by extracting, enriching and purifying the houttuynia and the honeysuckle. In combination with new dosage form of the ophthalmic instant-type gel, the gel has the advantages of accurate dosage, convenient use, improved bioavailability and lasting efficacy.

Description

technical field [0001] The invention belongs to the technical field of pharmacy and relates to an instant ophthalmic gel preparation made from honeysuckle and houttuynia cordata as raw materials through extraction and processing. Background technique [0002] Bacterial conjunctivitis, keratitis and viral keratoconjunctivitis are common and frequently-occurring diseases in clinical ophthalmology, with high incidence and long treatment time, and most of them are mixed infections. But at present, most of the medicines used to treat eye diseases clinically are chemical medicines with single function. At the same time as the infection, there are also bacterial infections, which brings a lot of inconvenience to the treatment. Eye drops have a short retention time in the eye and are eliminated quickly, which has the problem of low bioavailability of eye drugs. The matrix in the eye ointment can cause blurred vision or foreign body sensation in the eyes due to its transparency and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/00A61P27/02A61P31/04A61P31/12
Inventor 刘会臣
Owner 北京法玛赛科医药科技有限公司
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