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Acrylic acid ester shape-memory intraocular lens material and preparation method thereof

An intraocular lens and acrylate technology, applied in the field of biomedical materials, can solve problems such as hindrance, glare, eccentric displacement, etc.

Inactive Publication Date: 2009-10-28
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The object of the present invention is to provide an acrylic shape-memory intraocular lens material and its preparation method. This material can be used as an intraocular lens, and can overcome the glare, after-failure, and eccentric displacement existing in the existing folding intraocular lens. and other shortcomings

Method used

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  • Acrylic acid ester shape-memory intraocular lens material and preparation method thereof
  • Acrylic acid ester shape-memory intraocular lens material and preparation method thereof
  • Acrylic acid ester shape-memory intraocular lens material and preparation method thereof

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example 1

[0022] The selected monomers are (a): 2-phenoxyethyl acrylate (Sartomer), (b): 2-phenoxyethyl methacrylate (Sartomer). The selected monomer mass ratio is a / b=4 / 1wt%, the content of the crosslinking agent (ethylene glycol dimethacrylate, Beijing Oriental Acrylic Chemical Technology Co., Ltd.) is 1.5% of the total mass of the monomer, and the added The content of the thermal initiator (azobisisobutyronitrile, Shanghai No.4 Chemical Reagent Company) is 0.5% of the total mass of the monomers. Mix the monomer, cross-linking agent and initiator uniformly under the protection of nitrogen, then pour into the mold, heat and polymerize in an oven at 80°C for 24 hours, perform Soxhlet extraction to remove unreacted monomers and oligomers, and make shape-memory acrylate Material. The refractive index of the material is 1.5145, and the transmittance in the visible light region is as follows: figure 2 As shown, the glass transition temperature is 18.4°C, the elastic modulus at room tempe...

example 2

[0024] The selected monomers are (a): 2-phenoxyethyl acrylate (Sartomer), (b): 2-phenoxyethyl methacrylate (Sartomer), (c): Lauryl acrylate (Tianjin Tianjiao Chemical Co., Ltd.). The selected monomer mass ratio is a / b=4 / 1wt%, the content of c is 10.0% of the total mass of a and b, and the crosslinking agent (ethylene glycol dimethacrylate, Beijing Oriental Acrylic Chemical Technology Co., Ltd.) The content of the added thermal initiator (azobisisobutyronitrile, Shanghai Fourth Chemical Reagent Company) was 0.5% of the total mass of the monomers. Mix the monomer, cross-linking agent and initiator uniformly under the protection of nitrogen, then pour into the mold, heat and polymerize in an oven at 75°C for 36 hours, perform Soxhlet extraction to remove unreacted monomers and oligomers, and make shape-memory acrylate Material. The refractive index of the material is 1.509, and the transmittance in the visible light region is as follows: Figure 4 As shown, the glass transitio...

example 3

[0026] The selected monomers are (a): 2-phenoxyethyl acrylate (Sartomer), (b): 2-phenoxyethyl methacrylate (Sartomer), (c): Lauryl methacrylate (Tianjin Tianjiao Chemical Co., Ltd.). The selected monomer mass ratio is a / b=4 / 1wt%, the content of c is 5.0% of the total mass of a and b, and the crosslinking agent (ethylene glycol dimethacrylate, Beijing Oriental Acrylic Chemical Technology Co., Ltd.) The content of the added thermal initiator (azobisisobutyronitrile, Shanghai Fourth Chemical Reagent Company) was 0.5% of the total mass of the monomers. Mix the monomer, cross-linking agent and initiator uniformly under the protection of nitrogen, then pour into the mold, heat and polymerize in an oven at 75°C for 24 hours, perform Soxhlet extraction to remove unreacted monomers and oligomers, and make shape-memory acrylate Material. The refractive index of the material is 1.514, and the transmittance in the visible light region is as follows: Figure 5 As shown, the glass transi...

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Abstract

The invention provides an acrylic acid ester shape-memory intraocular lens material and a preparation method thereof, belonging to the field of biomedical material. The intraocular lens comprises the following basic materials of acrylic acid ester monomer crylic acid-2-phenoxy and methacrylic acid-2-phenoxy ethyl that are capable of being thermally polymerized and have a mass ratio of 3 / 1-9 / 1; furthermore, a cross linking agent and a thermal initiator are added in the basic materials; and the alkyl ester acrylate added in the material can control the thermodynamic performance of the polymerisate. The thermal-polymerization monomer, the thermal initiator and the cross linking agent can be uniformly mixed under the protection of the nitrogen and injected to a die for thermal polymerization reaction at the temperature of 70 DEG C-90 DEG C for 24-48 hours; and the shape-memory intraocular lens material is obtained by removing unreacted monomer and oligomer with a Soxhlet extraction method. The material has shape-memory performance; furthermore, the memory performance conversion temperature of the material can be adjusted to a body temperature, the deformation quantity of the material is large and the light transmittance at the visible light area is higher. The intraocular lens material can effectively reduce surgical incision and increase the effective optical area of intraocular lens simultaneously, and reduces the occurrence of complication such as clinical after-cataract, glare, etc.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an intraocular lens material and a preparation method thereof, in particular to selecting an acrylic monomer to prepare a shape-memory intraocular lens material. Background technique [0002] Intraocular lens implantation is the most effective way to restore vision to cataract patients, and the invention of this technology has brought a leap forward in the field of ophthalmology. The world's first intraocular lens implantation was completed in November 1949 by British ophthalmologist Ridley. Since then, the research on intraocular lenses has developed rapidly, and the intraocular lenses commonly used clinically are mainly divided into two types: rigid (non-foldable) intraocular lenses and folding intraocular lenses. Rigid intraocular lenses are mainly made of polymethyl methacrylate materials, while foldable intraocular lens materials mainly include polysilicone (silicone gel),...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61F2/16C08F220/30C08F222/14C08F2/00
Inventor 杨槐宋黎牛国光张红斌胡望朱思泉王国杰
Owner UNIV OF SCI & TECH BEIJING
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