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Decoquinate solid dispersoid and preparation method thereof

A solid dispersion and decoquinate technology, which is applied in the direction of medical preparations of non-active ingredients, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve the problem that decoquinate is not easy to disperse

Active Publication Date: 2010-12-29
烟台爱士津动物保健品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The invention provides a decoquinate solid dispersion and a preparation method thereof, aiming at overcoming the defect that decoquinate is not easy to disperse in water, having the characteristics of convenient production, storage, transportation and use, and providing farmers with a decoquinate solid dispersion with definite curative effect, Easy-to-use, high-quality anticoccidiostats

Method used

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  • Decoquinate solid dispersoid and preparation method thereof
  • Decoquinate solid dispersoid and preparation method thereof
  • Decoquinate solid dispersoid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Decoxyquinate 47.0g

[0018] Polyvinylpyrrolidone K30 47.0g

[0019] Polysorbate 60 6.0g

[0020] Preparation method and steps: add 47 parts of polyvinylpyrrolidone to 30 parts of water, stir and mix evenly, heat until completely dissolved, add 47 parts of decoquinate and 6 parts of polysorbate 60 to the ethanol solution of polyvinylpyrrolidone under stirring After mixing, a semi-fluid substance is obtained, which is ground by a colloid mill until it is completely mixed, then the material is dried under reduced pressure, crushed through a 120-mesh sieve, and the obtained solid is the decoquinate solid dispersion.

Embodiment 2

[0022] Decoxyquinate 16.0g

[0023] Polyvinyl alcohol 80.0g

[0024] Sodium Lauryl Sulfate 4.0g

[0025] Preparation method and steps: add 80 parts of polyvinyl alcohol into 60 parts of water, dissolve completely, add decoquinate into the aqueous solution of polyvinyl alcohol under stirring, then add sodium lauryl sulfate, and grind through a colloid mill Make the mixture uniform, dry under reduced pressure, remove all water, and pulverize into fine powder to obtain decoquinate dispersion.

Embodiment 3

[0027] Decoxyquinate 10.0g

[0028] Polyethylene glycol (4000) 85.0g

[0029] Polysorbate 80 5.0g

[0030] Preparation method and steps: add 85 parts of polyethylene glycol (4000) to 100 parts of water, heat until completely dissolved, and add decoquinate and polysorbate 80 to the solution containing polyethylene glycol (4000) under stirring. solution, continue to mix, grind through a colloid mill until the materials are uniformly mixed, and spray dry to obtain the decoquinate solid dispersion.

[0031] In order to verify the anti-coccidiostat effect of the product of the present invention, two kinds of anticoccidial drugs of the product of the present invention and decoquinate premix and decoquinate solution have been compared in drug efficacy tests, as follows:

[0032] Materials and Methods:

[0033] 1.1 Test chickens 60 1-day-old Avian broilers.

[0034] 1.2 Test drugs

[0035] Decoquinate premix: Yalai Pharmaceuticals, USA, containing 6.0% decoquinate;

[0036] Deco...

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Abstract

The invention relates to a decoquinate solid dispersoid and a preparation method thereof. The decoquinate solid dispersoid consists of decoquinate and a macromolecular carrier which are added with proper amount of surfactant. The mass ratio of the decoquinate to the macromolecular carrier is 1:0.5-1:12, preferably 1:0.8-1:8, and optimally 1:1-1:5. The preparation method comprises the following steps: dissolving the macromolecular carrier into a corresponding solvent first, and then suspending the decoquinate in the obtained solution; adding the surfactant to the solution; homogenizing the mixture through a high-pressure homogenizer or a colloid mill; and smashing the mixture into fine powder after spray drying or reduced-pressure drying to obtain the decoquinate solid dispersoid. The decoquinate solid dispersoid solves the difficulty that the decoquinate has poor hydrophilia and is not easy to disperse in water, can be watered for use clinically and has more convenient application. Thepreparation method has the advantages of simple process, short production cycle, and low energy consumption without residual solvent, and is applicable to industrial production.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a decoquinate solid dispersion and a preparation process. Background technique [0002] Livestock coccidiosis is a kind of intestinal parasitic disease, which is an important disease in the livestock and poultry industry in the world. Eimeria, Eimeria giant, Eimeria tenella, Eimeria poisonous and Eimeria metamorphosis, etc. These parasites multiply in the intestinal epithelial cells, destroy the integrity of the intestinal mucosa, and reduce the digestion and absorption capacity of the intestine. In poultry farming, 6-10% of mortality is caused by coccidiosis and leads to reduction in poultry growth rate and feed conversion efficiency, resulting in global economic losses amounting to billions of dollars per year. Because immunoprevention has not been fully popularized, so far, the main means of controlling coccidiosis is still chemical drug control, and the emergence...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/47A61K47/38A61K47/34A61P33/02A61K47/10A61K47/26
Inventor 张晓蓉刘哲林吕淑荣
Owner 烟台爱士津动物保健品有限公司
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