Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Decoquinate solid dispersoid and preparation method thereof

A solid dispersion and decoquinate technology, which is applied in the direction of medical preparations of non-active ingredients, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve the problem that decoquinate is not easy to disperse

Active Publication Date: 2009-10-28
烟台爱士津动物保健品有限公司
View PDF0 Cites 23 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The invention provides a decoquinate solid dispersion and a preparation method thereof, aiming at overcoming the defect that decoquinate is not easy to disperse in water, having the characteristics of convenient production, storage, transportation and use, and providing farmers with a decoquinate solid dispersion with definite curative effect, Easy-to-use, high-quality anticoccidiostats

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Decoquinate solid dispersoid and preparation method thereof
  • Decoquinate solid dispersoid and preparation method thereof
  • Decoquinate solid dispersoid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Decoxyquinate 47.0g

[0018] Polyvinylpyrrolidone K30 47.0g

[0019] Polysorbate 60 6.0g

[0020] Preparation method and steps: add 47 parts of polyvinylpyrrolidone to 30 parts of water, stir and mix evenly, heat until completely dissolved, add 47 parts of decoquinate and 6 parts of polysorbate 60 to the ethanol solution of polyvinylpyrrolidone under stirring After mixing, a semi-fluid substance is obtained, which is ground by a colloid mill until it is completely mixed, then the material is dried under reduced pressure, crushed through a 120-mesh sieve, and the obtained solid is the decoquinate solid dispersion.

Embodiment 2

[0022] Decoxyquinate 16.0g

[0023] Polyvinyl alcohol 80.0g

[0024] Sodium Lauryl Sulfate 4.0g

[0025] Preparation method and steps: add 80 parts of polyvinyl alcohol into 60 parts of water, dissolve completely, add decoquinate into the aqueous solution of polyvinyl alcohol under stirring, then add sodium lauryl sulfate, and grind through a colloid mill Make the mixture uniform, dry under reduced pressure, remove all water, and pulverize into fine powder to obtain decoquinate dispersion.

Embodiment 3

[0027] Decoxyquinate 10.0g

[0028] Polyethylene glycol (4000) 85.0g

[0029] Polysorbate 80 5.0g

[0030] Preparation method and steps: Add 85 parts of polyethylene glycol (4000) into 100 parts of water, heat until completely dissolved, and add decoquinate and polysorbate 80 into the solution containing polyethylene glycol (4000) under stirring. solution, continue to mix, grind through a colloid mill until the materials are uniformly mixed, and spray dry to obtain the decoquinate solid dispersion.

[0031] In order to verify the anti-coccidiostat effect of the product of the present invention, the product of the present invention was compared with two kinds of anticoccidial drugs of decoquinate premix and decoquinate solution, as follows:

[0032] Materials and Methods:

[0033] 1.1 Test chickens 60 1-day-old Avian broilers.

[0034] 1.2 Test drugs

[0035] Decoquinate premix: Yalai Pharmaceuticals, USA, containing 6.0% decoquinate;

[0036] Decoquinate solid dispersion...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a decoquinate solid dispersoid and a preparation method thereof. The decoquinate solid dispersoid consists of decoquinate and a macromolecular carrier which are added with proper amount of surfactant. The mass ratio of the decoquinate to the macromolecular carrier is 1:0.5-1:12, preferably 1:0.8-1:8, and optimally 1:1-1:5. The preparation method comprises the following steps: dissolving the macromolecular carrier into a corresponding solvent first, and then suspending the decoquinate in the obtained solution; adding the surfactant to the solution; homogenizing the mixture through a high-pressure homogenizer or a colloid mill; and smashing the mixture into fine powder after spray drying or reduced-pressure drying to obtain the decoquinate solid dispersoid. The decoquinate solid dispersoid solves the difficulty that the decoquinate has poor hydrophilia and is not easy to disperse in water, can be watered for use clinically and has more convenient application. The preparation method has the advantages of simple process, short production cycle, and low energy consumption without residual solvent, and is applicable to industrial production.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a decoquinate solid dispersion and a preparation process. Background technique [0002] Livestock coccidiosis is a kind of intestinal parasitic disease, which is an important disease in the livestock and poultry industry in the world. Eimeria, Eimeria giant, Eimeria tenella, Eimeria poisonous and Eimeria metamorphosis, etc. These parasites multiply in the intestinal epithelial cells, destroy the integrity of the intestinal mucosa, and reduce the digestion and absorption capacity of the intestine. In poultry farming, 6-10% of mortality is caused by coccidiosis and leads to reduction in poultry growth rate and feed conversion efficiency, resulting in global economic losses amounting to billions of dollars per year. Because immunoprevention has not been fully popularized, so far, the main means of controlling coccidiosis is still chemical drug control, and the emergence...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/47A61K47/38A61K47/34A61P33/02A61K47/10A61K47/26
Inventor 张晓蓉刘哲林吕淑荣
Owner 烟台爱士津动物保健品有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com